人神经上皮前体细胞的线粒体基因组操作-猫眼课题宝

人神经上皮前体细胞的线粒体基因组操作

批准号：

7333972

负责人：

JAMES PEPPER BENNETT

金额：

$19.01万

依托单位：

UNIVERSITY OF VIRGINIA

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-07-01 至 2008-06-30

来源：

https://reporter.nih.gov/project-details/7333972

关键词：

Adult Alzheimer&apos s Disease American Amyloid beta-Protein Precursor Animal Model Animals Apoptotic Astrocytes Award Beds Biomedical Engineering Brain Care given by nurses Cell Death Cell Line Cell Lineage Cell model Cells Cellular biology Chemicals Communities Cost of Illness DNA Development Disasters Disease Disease model Doctor of Medicine Doctor of Philosophy Economics Educational workshop Faculty Failure Future Genes Goals Grant Healthcare Systems Human Human Cell Line In Vitro Incentives Individual Industry Learning Left Logic Medical Methods Mitochondria Mitochondrial DNA Modeling Mus Mutation Nerve Degeneration Neurodegenerative Disorders Neuroepithelial Neuroepithelial, Perineurial, and Schwann Cell Neoplasm Neuroglia Neurology Neurons Neuroprotective Agents Numbers Oligodendroglia Output Parkinson Disease Pathogenesis Pathology Patients Pharmaceutical Preparations Phenotype Physicians Play Preclinical Drug Evaluation Presenile Alzheimer Dementia Process Reporting Research Research Personnel Role Rotenone Science Scientist Small Business Technology Transfer Research Source Standards of Weights and Measures Study models TNFRSF5 gene Techniques Technology Transfer Testing Therapeutic Transgenic Model Transgenic Organisms United States National Institutes of Health Universities Virginia Vulnerable Populations Work Writing alpha synuclein base brain cell career cost dopaminergic neuron drug development familial Alzheimer disease gene therapy human disease human embryonic stem cell human embryonic stem cell line immunoglobulin deposition disease improved in vivo insight member mitochondrial genome neoplastic neoplastic cell nerve stem cell neurotoxic novel parkin gene/protein pre-clinical precursor cell presenilin-1 prevent professor programs relating to nervous system respite care response selective expression socioeconomics success tau Proteins ubiquitin-protein ligase

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英文摘要

DESCRIPTION (provided by applicant): This is an application filed in response to RFA-DC-07-005 "Short-Term Interdisciplinary Career Enhancement Awards for Neuro-degeneration Research". The proposed candidate is James P. Bennett, Jr. M.D., Ph.D., who is currently Arthur and Margaret Ebbert Professor of Medical Science and Professor of Neurology at the University of Virginia (UVA). Dr. Bennett's entire 23-year academic career as a translational physician-scientist faculty member has been devoted to neurodegenerative research. He has held multiple NIH awards, beginning with a RCDA from 1985-1990, with subsequent awards of four R01 grants, two Program Projects and the P50 Udall Parkinson's Center at UVA that recently was competitively renewed through 2010. He has had significant translational output and presently holds a Physician-Sponsor IND for a novel neuroprotective drug and is PI for a STTR grant to develop mitochondrial gene therapy. He is a nationally known investigator into the mitochondrial pathobiology of neurodegenerative diseases. In the proposed career enhancement plan Dr. Bennett will learn how to derive neuroepithelial precursor (NEP) cells from NIH-approved human embryonic stem cells (hESC). He will learn this technique by attending a NIH-sponsored workshop followed by working closely with Dr. Raj Rao, a bioengineer on the faculty at Virginia Commonwealth University (VCU) and expert in neural stem cell biology. The goal of this project is for Dr. Bennett to create novel cell lines to serve as improved models of Alzheimer's (AD) and Parkinson's (PD) diseases by using a novel mitochondrial DNA (mtDNA) transfer technology to transfer AD and PD mtDNA into NEP cells depleted of their own mtDNA. These novel cell lines will allow exploration of unique disease pathogenesis hypotheses and will also serve as excellent drug screening platforms. The Award will allow Dr. Bennett to devote a 65% effort to this goal over 12 months of support. The precise causes of premature nerve cell death in Alzheimer's and Parkinson's patients' brains remain unknown. This award will support the creation of novel human nerve cells that carry mitochondrial genes from Alzheimer's and Parkinson's patients. These nerve cell lines can help scientists understand why nerve cells die prematurely in these diseases and can be used to develop new drugs to prevent cell death.

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