Mayo Clinic Vascular Medicine Clinical Research Training Program

描述(由申请人提供)： 动脉、静脉和淋巴管疾病很常见，往往是致命的，会导致慢性疼痛和损伤，并因医疗费用和收入损失而产生巨大成本。很少有医生受到足够的培训来照顾血管疾病患者，更少的医生进行血管疾病的转化性研究，这主要是因为血管医学的多学科临床研究培训实际上是不存在的。这项建议的长期目标是建立梅奥临床血管医学-临床研究培训计划(VM-CRTP)，并在临床血管医学以及以患者为中心的研究方面提供全面的培训。为了实现这一目标，我们提出了临床血管医学、血管生物学和转化研究的多学科课程，包括与既定研究人员的研究指导。拟议的计划将利用梅奥诊所现有的几种资源：(1)一个国际公认的多学科血管中心，为大量患有动脉、静脉和淋巴疾病的患者提供护理；(2)由NIH资助的两个临床研究培训计划(K30和K12)；(3)30多名从事与血管医学相关研究的研究员/导师；以及(4)通过K25机制培训和招募美洲原住民、妇女和来自经济发展中的大学的实习生的几项计划。梅奥诊所VM-CRTP的具体目标是：1)开发诊断和护理动脉、静脉或淋巴疾病患者的多学科临床培训计划；2)开发流行病学(包括遗传流行病学)和生物统计学原理、医疗保健经济学、血管生物学以及动脉、静脉和淋巴疾病的预防、诊断和治疗的综合教学工具；以及3)开发设计、实施和分析临床转化研究的教学和指导计划。这项拨款申请寻求用于课程开发和整合、候选人识别和招聘、临床培训和研究指导的资金。公共卫生声明：这项研究将教医生如何照顾患有血管疾病的患者，包括动脉、静脉和淋巴管疾病。此外，这项研究还将教会医生如何发现动脉、静脉和淋巴管疾病的新病因，以及预防和治疗这些疾病的新方法。

DESCRIPTION (provided by applicant): Diseases of the arteries, veins, and lymphatics are common and frequently lethal, cause chronic pain and impairment, and incur substantial costs due to health care charges and lost earnings. Few physicians are adequately trained to care for patients with vascular diseases and even fewer perform translational research in vascular diseases, largely because multidisciplinary clinical research training in vascular medicine is virtually non-existant. The long-term goal of this proposal is to establish a Mayo Clinic Vascular Medicine-Clinical Research Training Program (VM-CRTP) and provide comprehensive training in both clinical vascular medicine as well as patient-oriented research. To accomplish this goal, we propose a multidisciplinary curriculum in clinical vascular medicine, vascular biology and translational research, including a research mentorship with an established investigator. The proposed program will leverage several resources already available at the Mayo Clinic: (1) an internationally recognized multidisciplinary Vascular Center that provides care for a large number of patients with arterial, venous, and lymphatic diseases; (2) two NIH-funded (K30 and K12) clinical research training programs; (3) over 30 investigator/mentors engaged in research relevant to vascular medicine; and (4) several initiatives to train and recruit Native Americans, women, and trainees from economically developing universities through a K25 mechanism. The specific aims of the Mayo Clinic VM-CRTP are: 1) to develop a multidisciplinary clinical training program in the diagnosis and care of the patient with arterial, venous or lymphatic diseases; 2) to develop comprehensive teaching tools on the principles of epidemiology (including genetic epidemiology) and biostatistics, health care economics, vascular biology, and the prevention, diagnosis and treatment of arterial, venous and lymphatic diseases; and 3) to develop a teaching and mentoring program in the design, conduct and analysis of clinical translational research. This grant application seeks funding for curriculum development and integration, candidate identification and recruitment, clinical training, and research mentorship. Public Health statements: This research will teach doctors how to take care of patients with diseases of the blood vessels, including diseases of arteries, veins and lymph vessels. In addition, this research will teach doctors how to discover new causes of diseases of arteries, veins and lymph vessels, as well as new ways to prevent and treat these diseases.