Melanoma Margins Trial-II: A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm vs 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT-II)

黑色素瘤边缘试验-II：一项 III 期、多中心随机对照试验，研究 AJCC II 期原发性皮肤黑色素瘤的 1 厘米与 2 厘米宽手术切除边缘 (MelMarT-II)

• 批准号: nhmrc : GNT1161574
• 金额: $ 276.66万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/melanoma-margins-trial-melmart-ii/1379180
• 关键词: Melanoma; Margins; Trial; II; Phase

Primary melanomas (PM) are routinely excised with a wide margin to prevent recurrence. For patients with higher risk PM, there is debate as to the extent of the excision margin. We propose a 1cm margin will achieve equivalent survival outcomes to the recommended 2cm margin for patients with higher risk PM, while improving quality of life and reducing costs to the community. This trial will benefit patients worldwide, influencing care, clinical practice and future treatment guidelines.

原发性黑色素瘤 (PM) 通常会进行较宽的切缘切除，以防止复发。对于 PM 风险较高的患者，对于切除边缘的范围存在争议。我们建议，对于 PM 风险较高的患者，1 厘米的边缘将获得与推荐的 2 厘米边缘相同的生存结果，同时提高生活质量并降低社区成本。该试验将使全世界的患者受益，影响护理、临床实践和未来的治疗指南。