Epigenetic Biomarkers of Postpartum Psychosis

产后精神病的表观遗传生物标志物

基本信息

批准号：
10722691
负责人：
JENNIFER L PAYNE
金额：
$ 45.11万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-02 至 2025-08-01
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10722691
关键词：
Acute Algorithms Basic Science Biological Markers Bipolar Disorder Blood Blood specimen Brain CLIA certified Childbirth Clinical Clinical Research Confusion Contraceptive Usage DNA Delirium Depressed mood Disease Epigenetic Process Etiology Event Genes Genetic High Risk Woman Hormonal Hormonal Change Hospitalization Immune Individual Infanticide Luteal Phase Machine Learning Manic Mental Depression Mental disorders Microarray Analysis Mission Modeling Modification Mood Disorders Moods National Institute of Mental Health Netherlands Onset of illness Patients Perimenopause Postpartum Depression Postpartum Period Predisposition Pregnancy Prevention Preventive measure Psychoses Publishing Recovery Risk Sampling Specificity Specimen Suicide Symptoms Third Pregnancy Trimester Time Woman Work bead chip biomarker identification blood-based biomarker candidate marker cohort comparison control depressive symptoms epigenetic marker experience genome wide methylation genome-wide hormonal contraception improved methylation pattern mood symptom novel predictive marker premenstrual dysphoric disorder prevent psychiatric emergency psychosis risk psychotic reproductive reproductive hormone risk prediction sample collection sodium bisulfite specific biomarkers suicidal risk support vector machine

项目摘要

Abstract Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women. We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time- period. We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations. This proposal will take advantage of a unique sample of blood specimens collected in the Netherlands from women with Postpartum Psychosis and will determine if our epigenetic biomarkers are also associated with Postpartum Psychosis. We will also conduct a genome wide microarray analyses in order to identify epigenetic biomarkers that are specific to Postpartum Psychosis. Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period. Postpartum Psychosis almost always requires psychiatric hospitalization and carries with it an elevated risk of suicide and infanticide. Identification of blood-based biomarkers that are predictive of an increased risk for Postpartum Psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.

抽象的生殖情绪发作，例如产后抑郁症，经前烦躁不安和产后精神病是女性生殖激素变化引起的情绪发作。我们有以前在TTC9B和HP1BP3基因上鉴定出了两个产后抑郁症的表观遗传生物标志物在预测哪些女性会在产后时间抑制哪些女性时，大约是80％时期。我们最近表明，这些生物标志物也与经前期的女性有关当在月经周期的黄体阶段取样血液时，烦躁不安对生殖激素波动的敏感性更普遍。该提议将采取产后女性在荷兰收集的独特血液样本样本的优势精神病，将确定我们的表观遗传生物标志物是否也与产后精神病有关。我们还将进行基因组广泛的微阵列分析，以鉴定表观遗传生物标志物特定于产后精神病。产后精神病是一种严重的精神病，在产后立即。产后精神病几乎总是需要精神病医院并带有自杀和杀婴的风险升高。鉴定基于血液的生物标志物预测产后精神病的风险增加将允许采取预防措施消除精神病紧急情况，并在产后关键时期内预防住院。