Epigenetic Biomarkers of Postpartum Psychosis

产后精神病的表观遗传生物标志物

• 批准号: 10722691
• 负责人: JENNIFER L PAYNE
• 金额: $ 45.11万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-02 至 2025-08-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10722691
• 关键词: Acute; Algorithms; Basic Science; Biological Markers; Bipolar Disorder; Blood; Blood specimen; Brain; CLIA certified; Childbirth; Clinical; Clinical Research; Confusion; Contraceptive Usage; DNA; Delirium; Depressed mood; Disease; Epigenetic Process; Etiology; Event; Genes; Genetic; High Risk Woman; Hormonal; Hormonal Change; Hospitalization; Immune; Individual; Infanticide; Luteal Phase; Machine Learning; Manic; Mental Depression; Mental disorders; Microarray Analysis; Mission; Modeling; Modification; Mood Disorders; Moods; National Institute of Mental Health; Netherlands; Onset of illness; Patients; Perimenopause; Postpartum Depression; Postpartum Period; Predisposition; Pregnancy; Prevention; Preventive measure; Psychoses; Publishing; Recovery; Risk; Sampling; Specificity; Specimen; Suicide; Symptoms; Third Pregnancy Trimester; Time; Woman; Work; bead chip; biomarker identification; blood-based biomarker; candidate marker; cohort; comparison control; depressive symptoms; epigenetic marker; experience; genome wide methylation; genome-wide; hormonal contraception; improved; methylation pattern; mood symptom; novel; predictive marker; premenstrual dysphoric disorder; prevent; psychiatric emergency; psychosis risk; psychotic; reproductive; reproductive hormone; risk prediction; sample collection; sodium bisulfite; specific biomarkers; suicidal risk; support vector machine

Abstract Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women. We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time- period. We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations. This proposal will take advantage of a unique sample of blood specimens collected in the Netherlands from women with Postpartum Psychosis and will determine if our epigenetic biomarkers are also associated with Postpartum Psychosis. We will also conduct a genome wide microarray analyses in order to identify epigenetic biomarkers that are specific to Postpartum Psychosis. Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period. Postpartum Psychosis almost always requires psychiatric hospitalization and carries with it an elevated risk of suicide and infanticide. Identification of blood-based biomarkers that are predictive of an increased risk for Postpartum Psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.

摘要 生殖情绪发作，如产后抑郁症、经前焦虑症和 产后精神病，是由女性生殖激素变化引发的情绪发作。我们有 此前在TTC9B和HP1BP3基因上发现了两个产后抑郁症的表观遗传生物标志物 预测哪些女性产后会抑郁的准确率约为80%- 句号。我们最近发现，这些生物标志物也与有经前症状的女性有关。 在月经周期的黄体期采血时出现的烦躁不安的疾病，表明他们可能 成为大脑对生殖激素波动敏感的更通用的生物标志物。这项建议将需要 在荷兰从产后妇女身上采集独特血样的优势 并将确定我们的表观遗传生物标记物是否也与产后精神病有关。我们 还将进行全基因组微阵列分析，以识别表观遗传生物标记物 专门针对产后精神病。产后精神病是一种严重的精神疾病，急性发作于 产后即刻时间段。产后精神病几乎总是需要精神科住院治疗 随之而来的是自杀和杀婴的风险增加。基于血液的生物标记物的鉴定 预测产后精神病的风险增加将允许采取预防措施，这可能 消除精神急症，防止在产后的关键时期住院。