Genetics of Postpartum Depression in Affective Disorders

情感障碍产后抑郁症的遗传学

• 批准号: 7561750
• 负责人: JENNIFER L PAYNE
• 金额: $ 18.32万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561750
• 关键词: Bipolar Disorder; Cells; Chairperson; Clinical; Clinical Trials; Collection; Data; Data Set; Diagnostic; Diagnostic Procedure; Ensure; Epidemiology; Estrogens; Family; Family Study; Fellowship; Five-Year Plans; Foundations; Functional disorder; Future; Genes; Genetic; Genetic Determinism; Genetic Predisposition to Disease; Genetic Research; Goals; Hormonal Change; Hormones; Individual; Interview; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Major Depressive Disorder; Mental Health; Mentors; Mood Disorders; Moods; National Institute of Mental Health; North Carolina; Patients; Population; Positioning Attribute; Postpartum Depression; Postpartum Period; Pregnant Women; Psychiatrist; Psychiatry; Public Health Schools; Recording of previous events; Recurrence; Reproductive Endocrinology; Research; Research Personnel; Resources; Response Elements; Risk; Sampling; Series; Statistical Methods; Steroids; Subgroup; Symptoms; Testing; Time; Training; Training Programs; Treatment outcome; Universities; Variant; Woman; Work; base; depression; depressive symptoms; genetic epidemiology; genetic linkage analysis; improved; innovation; interest; neurobehavioral; professor; statistics; trait; treatment strategy

DESCRIPTION (provided by applicant): This career development award proposal is a five-year plan that will enable the candidate to develop into an independent investigator in the genetics of affective disorders with an emphasis on hormonally-triggered symptoms in women. The candidate is an academic psychiatrist with training in mood disorders who now seeks further training in genetics and genetic epidemiology. Dr. J. Raymond DePaulo, Jr, director of the Affective Disorders Genetics Research Group and Chair of the Johns Hopkins Department of Psychiatry will mentor the candidate on conducting genetic research in the psychiatric patient. Dr. Terri Beaty, Professor at the Johns Hopkins School of Public Health, will mentor the candidate on using statistical methods and genetic epidemiology. Dr. David Rubinow, Professor and Chair of Psychiatry at the University of North Carolina and Dr. Peter Schmidt, Chief of the Unit on Reproductive Endocrinology Studies, will mentor the candidate in both the neurobehavioral effects of gonaldal steroids as well as clinical and phenotypic issues in women's mental health. The training program will be enhanced by a research plan based on the hypothesis that women with postpartum depressive episodes have a genetic vulnerability to times of normal hormonal change that consists of variation in a gene (or genes) that is estrogen responsive. The research plan will take advantage of previously collected family samples of bipolar disorder and recurrent major depression. Based on preliminary data demonstrating the familiality of postpartum depressive episodes in families with major depression and bipolar disorder, the candidate will complete the following three specific aims: 1) complete a linkage analysis for this trait; 2) perform association studies, specifically examining genes in regions of interest which contain estrogen-response elements and thus may be susceptible to the hormone fluctuations that occur during the postpartum period; and 3) begin collection of a pilot sample of women with major depression with and without postpartum depression. The proposed research is significant because it will lead to a better understanding of the pathophysiology of postpartum depression in women with mood disorders as well as potentially contribute to understanding the increased rate of depressive episodes observed in women as a group.

描述（由申请人提供）：该职业发展奖提案是一项为期五年的计划，该计划将使候选人能够发展为情感障碍遗传学的独立研究者，重点是女性激素触发的症状。候选人是一名学术精神科医生，接受了情绪障碍的培训，他们现在寻求进一步的遗传学和遗传流行病学培训。小J. Raymond DePaulo博士，情感障碍遗传学研究小组主任兼约翰·霍普金斯精神病学系主任，将指导候选人在精神病患者中进行遗传研究。约翰·霍普金斯公共卫生学院教授特里·比迪（Terri Beaty）博士将指导候选人使用统计方法和遗传流行病学。北卡罗来纳大学精神病学教授兼主席戴维·鲁比诺（David Rubinow）和生殖内分泌研究单位主任彼得·施密特（Peter Schmidt）博士将指导候选人在男性层类固醇类固醇的神经行为影响以及妇女心理健康中的临床和表型问题的神经行为影响中。研究计划将根据以下假设来增强培训计划，即产后抑郁发作的妇女对正常激素变化时代具有遗传脆弱性，该脆弱性包括雌激素反应的基因（或基因）的变化。该研究计划将利用先前收集的躁郁症和复发性重大抑郁症的家庭样本。基于初步数据表明产后抑郁症的家族性在严重抑郁症和躁郁症的家庭中，候选人将完成以下三个特定目标：1）完成此特征的链接分析； 2）进行关联研究，专门检查含有雌激素反应元件的感兴趣区域中的基因，因此可能易受产后期间激素波动的影响； 3）开始收集有和没有产后抑郁症的严重抑郁症女性的试验样本。拟议的研究很重要，因为它将更好地理解情绪障碍女性产后抑郁症的病理生理学，并有可能有助于理解女性作为一个组中观察到的抑郁发作率的增加。