10th International Conference on Tularemia

摘要/摘要 该提案寻求对第十届图拉热病国际会议的支持，该会议将于#年#月#日举行。 2023年9月25日至28日，法国格勒诺布尔。图拉热症是一种进展迅速并可能致命的疾病。 由细胞内细菌病原体图拉氏方济氏菌引起的人畜共患病。因为它太低了 吸入时的感染剂量和致死率图拉氏丝虫是一种生物武器，至今仍是一种 潜在的生物恐怖分子。图拉热症发病机制、诊断、治疗和治疗的研究与认识 关于图拉热症的国际会议大大推进了预防工作。出席人数和 这次会议的影响在随后的几年里稳步增长。这次会议是一个独特的场所，它带来了 来自美国、加拿大、斯堪的纳维亚半岛、欧洲、中东和 日本。CBER/FDA一直致力于促进制定医疗对策 生物恐怖主义和新发传染病。推进医学对策的发展是一种 这次会议的明确目标。各级资深科学家、临床医生和实习生出席；与会者与 弗朗西塞拉社区以外的知识和兴趣也带来了视角和启迪 比较。会议旨在提供一个促进协作和免费的环境 思想交流。过去会议的亮点包括宣布弗朗西塞拉的发现 致病岛；由致病岛编码的VI型分泌系统；新动物的开发 模型；详细的基因组和蛋白质组特征，为疾病流行病学和 开发新的治疗方案；以及确定该细菌的免疫逃避策略 推进疫苗研发。2023年大会将包括一次主旨演讲和六次全体会议 会议、海报预览(闪电演讲)和三个海报会议，以及更多的网络机会 在共享用餐和社交活动期间。六次全体会议将突出在以下方面的最新进展 图拉热症的诊断和治疗，疫苗的开发，宿主对感染的反应，流行病学和 细菌生态学、细菌生理学和基因调控、发病机制和细胞生物学。每一次全体会议 会议将由该领域公认的领导者科学家主持。超过85%的演讲者将是 根据提交的摘要的优点进行选择。为了实现这些目标，我们寻求会议的支持。 后勤将允许传播研究成果以及与会者的专业发展。 具体而言，我们请求支助租用演示设备(视听服务和海报)， 会议管理和网站开发，为与会者提供财务和差旅支持 教育需求。

SUMMARY/ABSTRACT This proposal seeks support for the 10th International Conference on Tularemia, which will be held from September 25 – 28, 2023, in Grenoble, France. Tularemia is a rapidly progressive and potentially fatal zoonosis of humans caused by the intracellular bacterial pathogen, Francisella tularensis. Because of its low infectious dose and lethality when inhaled, F. tularensis was developed as a bioweapon, and remains a potential bioterrorist agent. Research and understanding of tularemia pathogenesis, diagnosis, treatment, and prevention have been significantly advanced by the International Conferences on Tularemia. Attendance and impact of this meeting has grown steadily in subsequent years. This conference is a unique venue that brings together scientists and interested parties from the U.S., Canada, Scandinavia, Europe, the Middle East, and Japan. CBER/FDA has an ongoing commitment to facilitating development of medical countermeasures for bioterrorism and emerging infectious diseases. Advancing development of medical countermeasures is an explicit goal of this meeting. Senior scientists, clinicians, and trainees at all levels attend; attendees with knowledge and interests outside the Francisella community also bring perspective and instructive comparisons. The conference is designed to provide an environment that fosters collaboration and a free exchange of ideas. Highlights from past meetings include announcing the discoveries of the Francisella pathogenicity island (FPI); the Type VI secretion system encoded by the FPI; development of new animal models; detailed genomic and proteomic characterizations that inform epidemiology of disease and development of new therapeutic options; and identification of immune evasion strategies of the bacterium that advance vaccine development. The 2023 conference will include a keynote address as well as six plenary sessions, poster previews (flash talks) and three poster sessions, and additional opportunities for networking during shared meals and social activities. The six plenary sessions will highlight the latest advances in diagnosis and treatment of tularemia, vaccine development, host responses to infection, epidemiology and bacterial ecology, bacterial physiology and gene regulation, and pathogenesis and cell biology. Each plenary session will be chaired by scientists who are recognized leaders in the field. Over 85% of speakers will be selected based on the merit of submitted abstracts. To achieve these goals, we seek support for meeting logistics that will allow dissemination of research findings as well as professional development of attendees. Specifically, we request support for rental of presentation equipment (audiovisual services and poster boards), conference management and web site development, and travel support for attendees with financial and educational needs.