Functional Infrared Imaging Predicts Radiation Mucositis

功能红外成像预测放射性粘膜炎

• 批准号: 7314563
• 负责人: Ezra Cohen
• 金额: $ 16.09万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7314563
• 关键词: Absence of pain sensation; Acute; Adverse effects; Algorithms; Analgesics; Caring; Combination Chemotherapy; Complication; Computers; Detection; Dose; Early Diagnosis; Early Intervention; Enteral Nutrition; Functional disorder; Head and Neck Cancer; Image; Injury; Interruption; Laboratories; Location; Measures; Modality; Mucositis; Mucous Membrane; Narcotics; Noise; Normal tissue morphology; Oral cavity; Oropharyngeal; Patient Schedules; Patients; Population; Prevention; Primary Neoplasm; Quality of life; Radiation; Radiation therapy; Randomized Controlled Clinical Trials; Reaction; Risk; Severities; Signal Transduction; Skin; Standards of Weights and Measures; Supportive care; Symptoms; Temperature; Time; Tissues; Toxic effect; Variant; experience; functional disability; head and neck cancer patient; oral mucositis; tool; tube feeding

DESCRIPTION (provided by applicant): Many patients with locally advanced head and neck cancer (HNC) will be treated with curative intent chemoradiotherapy (CRT). This approach has been validated in several randomized trials and is an accepted standard of care. CRT has associated toxicity including almost universal mucositis in the radiation field. The severity of toxicity, however, varies widely with some patients experiencing only mild symptoms while others require narcotic analgesia, enteral nutrition, and interruption of therapy. Radiotherapy volumes will be predictive of the location of adverse effects but not the degree. At this time, there are no modalities that allow accurate prediction of CRT induced toxicity in HNC patients. Tissue injury induced by CRT results in regional temperature variations that can be detected by infrared (IR) imaging. Argonne National Laboratory has developed a compact computer-piloted high sensitivity IR imager with special signal detection algorithms that would allow detection of small temperature variations with little background noise. We hypothesize that alterations in thermal intensity early in therapy will be predictive of patients who will develop severe mucocutaneous toxicity. Detection of these early changes by IR imaging would identify a group of patients that will require more intensive supportive care and who may be candidates for de-intensification of therapy to avoid serious toxicity. The majority of patients with head and neck cancer will be treated with combination chemotherapy and radiotherapy and will suffer acute toxicity in the form of oral mucositis. However, there is no way to predict which patients will develop severe mucositis during therapy that often requires treatment interruption, dose reduction, narcotic analgesia, and tube feeding. We hypothesize that thermal imaging will confer the ability to predict which patients are at risk for this complication and would subsequently allow for early intervention and prevention. Such a tool would have wide applicability in this patient population and would have tremendous impact on their treatment.

描述(申请人提供)：许多局部晚期头颈癌(HNC)患者将接受治疗意向放化疗(CRT)。这种方法已经在几个随机试验中得到了验证，是一种公认的护理标准。CRT有相关的毒性，包括在辐射领域几乎普遍的粘膜炎。然而，毒性的严重程度差别很大，一些患者只出现轻微的症状，而另一些患者需要麻醉性止痛、肠内营养和中断治疗。放疗量可以预测不良反应的部位，但不能预测不良反应的程度。目前，还没有方法可以准确预测CRT对HNC患者的毒性。CRT引起的组织损伤引起的局部温度变化可以通过红外成像进行检测。阿贡国家实验室开发了一种紧凑的计算机控制的高灵敏度红外成像仪，它具有特殊的信号检测算法，可以在几乎没有背景噪音的情况下检测到微小的温度变化。我们假设，治疗早期温度强度的变化将预测将发生严重皮肤粘膜毒性的患者。通过红外成像检测到这些早期变化将确定一组需要更多强化支持治疗的患者，他们可能是非强化治疗的候选者，以避免严重的毒性。大多数头颈癌患者将接受联合化疗和放射治疗，并将遭受口腔粘膜炎形式的急性毒性。然而，没有办法预测哪些患者在治疗过程中会出现严重的粘膜炎，这些治疗通常需要中断治疗、减少剂量、麻醉止痛和导管喂养。我们假设热成像将能够预测哪些患者存在这种并发症的风险，并随后允许早期干预和预防。这样的工具将在这一患者群体中具有广泛的适用性，并将对他们的治疗产生巨大影响。