Nephrology Training Grant

描述(由申请人提供)： 基本原理和目标：该申请建议在俄勒冈健康与科学大学为肾脏病和高血压方面的内科科学家和博士科学家建立一个以研究为基础的培训计划。其目的是通过在互动环境中提供以临床或实验室为基础、以假设为导向、基础和以疾病为导向的研究方面的强化培训，为个人成功的学术/科学职业生涯做好准备。这项计划的前提是，随着分子医学的发展对高血压和肾脏疾病的预防、诊断和治疗产生更大的影响，对熟练的内科研究人员的需求将随着时间的推移而增加。 培训计划的结构：本申请寻求3名博士后实习生(第一年2名)的支持。对于医学博士科学家，研究培训之前将有一年的临床培训，并有正规的教育活动，教授肾脏病的科学基础。临床年将通过机构资源提供资金。在这一年中，考生将与适当的导师配对，为研究期间做准备。随后的几年(2年或更长时间)将由这笔资金用于实验室或临床研究。对于博士科学家来说，在进行研究培训之前，将成功完成基础科学学科的博士项目。对于所有考生，研究活动将由期刊俱乐部、实验室小组会议和针对受训者个人科学目标量身定做的课程工作来补充。 研究领域和学科：该计划将汇集来自肾脏病和心脏病学系的研究人员。首页--期刊主要分类--期刊细介绍--期刊题录与文摘--文摘内容儿科；医学信息学和临床流行病学、生物化学、生理学和药理学系；以及其他相关院系。研究人员和受训人员将被分成相互关联的基本主题兴趣领域：高血压、慢性肾脏疾病和肾脏生理学/信号。每个小组中将有在分子生物学、生理学、血管生物学和相关学科方面具有专业知识的科学家代表。俄勒冈健康与科学大学和波特兰退伍军人医学中心的最先进的实验室将作为板凳研究的培训设施。临床研究项目有机会进入OHSU GCRC、人类调查和临床研究或公共卫生硕士项目。 相关性：该计划将培训研究高血压和慢性肾脏疾病的研究人员，这两个问题在美国都是主要的且日益严重的公共卫生问题。

DESCRIPTION (provided by applicant): Rationale and Aims: This application proposes to establish a research-based training program for physician-scientists and Ph.D. scientists in Nephrology and Hypertension at the Oregon Health and Science University. The aim is to prepare individuals for successful academic/scientific careers, by providing intensive training in clinical or laboratory-based, hypothesis-driven, basic and disease- oriented research in an interactive environment. The premise of this program is that the need for skilled physician-investigators will increase over time as developments in molecular-based medicine have greater impact on the prevention, diagnosis, and treatment of hypertension and renal disease. Structure of the Training Program: This application seeks support for 3 postdoctoral trainees (2 in the first year). For M.D. scientists, research training will be preceded by a year of clinical training, with formal educational activities which teach the scientific basis of nephrology. The clinical year will be funded through institutional resources. During this year, candidates will be matched with appropriate mentors in preparation for the research period. Subsequent years (2 or more) will be devoted to laboratory or clinical research, funded by this grant. For Ph.D. scientists, the research training will be preceded by successful completion of a Ph.D. program in a basic science discipline. For all candidates, research activities will be supplemented by journal clubs, laboratory group meetings, and course work tailored to the trainee's individual scientific goals. Research Areas and Disciplines: This program will bring together investigators from the Divisions of Nephrology and Cardiology, Dept. of Medicine; the Division of Pediatric Nephrology, Dept. of Pediatrics; the Departments of Medical Informatics and Clinical Epidemiology, Biochemistry, and Physiology and Pharmacology; and other associated faculty. Investigators and trainees will be grouped into interrelated basic thematic interest areas: Hypertension, Chronic Kidney Disease, and Renal Physiology/Signaling. Within each group will be represented scientists with expertise in molecular biology, physiology, vascular biology, and related disciplines as appropriate. State-of-the-art laboratories at the Oregon Health and Science University and the Portland VA Medical Center will serve as training facilities for bench research. The clinical research projects have access to the OHSU GCRC, and the Human Investigations, and Masters in Clinical Research or Public Health programs. Relevance: This program will train investigators in the study of hypertension and chronic kidney disease, which are both major and growing public health problems in the U.S.