Nephrology Training Grant

肾脏病学培训补助金

• 批准号: 8078740
• 负责人: David H Ellison
• 金额: $ 11.91万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078740
• 关键词: Grant; Nephrology; Training

DESCRIPTION (provided by applicant): This application proposes continued support for a successful research-based training program in Nephrology and Hypertension at Oregon Health & Science University. This is the first competing renewal for this program, now in its fourth year, supporting two trainees per year. Its overarching goal is to prepare qualified post doctoral trainees for successful scientific careers as independent investigators; to achieve this aim, it will provide intensive training in hypothesis-driven, and hypothesis generating, basic and disease-oriented research in a stimulating and collegial academic environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. Successful MD candidates will have completed residency training as well as a first, clinical, year of Nephrology fellowship training prior to enrolling in This Program. This requirement allows both MD and PhD trainees to devote at least 80% of their time to first-hand experience and training in research under the supervision of an established successful investigator. Research activities will be supplemented by a structured didactic program consisting of weekly journal clubs, research-in-progress meetings, Renal Research Conferences, and formal graduate level course work, tailored to the individual scientific needs of each trainee. For trainees pursuing clinically oriented research, the didactic program is expected to lead to a Master's Degree in Clinical Research. Special strengths of the program include: 1) The diverse skills and research interests of the faculty in timely areas including diabetic nephropathy, chronic kidney disease, gender-based kidney disease, hypertension, ion and solute transport, clinical disorders of electrolyte concentration, transplantation medicine and immunobiology, and protein trafficking and lipid biochemistry. Clinical research interests include patient-oriented outcomes research into effects of cardiovascular disease on renal transplantation, molecular mechanisms of hypertension, and chronic kidney disease care in rural areas, 2) the recently expanded clinical research resources supported by OHSU's Clinical and Translational Science Award (one of the first in the nation), which facilitates training in state-of-the-art clinical investigation; 3) continuing growth of OHSU as a major research-oriented Medical School (ranked 23rd in NIH funded research, 2009), and 4) the structured mentorship and evaluation model that has been developed and will be enumerated herein. A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades, and that this need is critical for continued advancements in human health care. ! PUBLIC HEALTH RELEVANCE: Serious kidney disease affects more than 8 million Americans, causing untold suffering and early death. This program seeks to train academic nephrologists and kidney scientists who will function as independent investigators capable of developing research programs to address the causes of kidney disease and hypertension, and to develop new and improved treatments for it.

描述（由申请人提供）：本申请建议继续支持俄勒冈州健康与科学大学在肾脏病学和高血压方面成功的基于研究的培训计划。这是该计划的第一次竞争性更新，现在已经是第四年了，每年支持两名学员。其总体目标是培养合格的博士后学员作为独立调查人员成功从事科学事业;为了实现这一目标，它将在激励和学院式的学术环境中提供假设驱动和假设生成，基础和疾病导向研究的强化培训。潜在的候选人将持有MD，MD/PhD或PhD学位。成功的医学博士候选人将完成住院医师培训以及第一年的临床肾脏病学奖学金培训，然后再参加该计划。这一要求允许医学博士和博士生将至少80%的时间投入到第一手的经验和培训研究的监督下建立成功的调查。研究活动将由一个结构化的教学计划补充，该计划包括每周杂志俱乐部，研究进展会议，肾脏研究会议和正式的研究生水平课程，根据每位学员的个人科学需求量身定制。对于追求临床导向研究的学员，教学计划预计将导致临床研究硕士学位。该计划的特殊优势包括：1）教师在及时领域的多样化技能和研究兴趣，包括糖尿病肾病，慢性肾脏疾病，基于性别的肾脏疾病，高血压，离子和溶质转运，电解质浓度的临床疾病，移植医学和免疫生物学，蛋白质运输和脂质生物化学。临床研究兴趣包括以患者为导向的心血管疾病对肾移植的影响，高血压的分子机制和农村地区慢性肾脏病护理的结果研究，2）最近获得OHSU临床和转化科学奖支持的临床研究资源（全国首批之一），促进了最先进的临床研究培训; 3）OHSU作为一个主要的研究型医学院的持续增长（在NIH资助的研究中排名第23位，2009年），以及4）已经开发并将在此列举的结构化导师和评估模型。培训计划的一个主要前提是，在未来几十年内，对熟练的医生调查人员的需求只会继续增加，这种需求对于人类医疗保健的持续进步至关重要。! 公共卫生相关性：严重的肾脏疾病影响着800多万美国人，造成难以形容的痛苦和过早死亡。该计划旨在培养学术肾病学家和肾脏科学家，他们将作为独立的调查人员，能够开发研究计划，以解决肾脏疾病和高血压的原因，并开发新的和改进的治疗方法。