Nephrology Training Grant

描述（由申请人提供）：本申请建议继续支持俄勒冈健康与科学大学肾病学和高血压学的一个成功的研究型培训项目。这是该项目第一次竞争性续约，目前已进入第四个年头，每年支持两名学员。其总体目标是准备合格的博士后学员成功的科学事业作为独立研究者；为了实现这一目标，它将在一个激励和合议的学术环境中提供假设驱动和假设生成、基础和疾病导向研究方面的强化培训。潜在候选人需要拥有医学博士、医学博士/博士学位或博士学位。成功的医学博士候选人将在参加本项目之前完成住院医师培训以及第一年的临床肾脏学奖学金培训。这一要求允许医学博士和博士学员在成功研究者的指导下投入至少80%的时间进行第一手研究经验和培训。研究活动将辅以结构化的教学计划，包括每周的期刊俱乐部、正在进行的研究会议、肾脏研究会议和正式的研究生水平课程，根据每个学员的个人科学需求量身定制。对于从事临床导向研究的学员，该教学项目有望获得临床研究硕士学位。1)在糖尿病肾病、慢性肾病、性别肾病、高血压、离子和溶质转运、电解质浓度临床紊乱、移植医学和免疫生物学、蛋白质转运和脂质生物化学等及时领域，教师的技能和研究兴趣多样化。临床研究兴趣包括以患者为导向的心血管疾病对肾移植的影响、高血压的分子机制和农村地区慢性肾病护理的结果研究。2)最近由OHSU临床和转化科学奖（全国首批奖项之一）支持的临床研究资源的扩大，促进了最先进的临床研究培训；3) OHSU作为一个主要的研究型医学院的持续发展（2009年NIH资助研究排名第23位），以及4)已经开发并将在此列举的结构化指导和评估模型。培训计划的一个主要前提是，对熟练的医师调查员的需求在未来几十年只会继续增加，而且这种需求对人类卫生保健的持续进步至关重要。！

DESCRIPTION (provided by applicant): This application proposes continued support for a successful research-based training program in Nephrology and Hypertension at Oregon Health & Science University. This is the first competing renewal for this program, now in its fourth year, supporting two trainees per year. Its overarching goal is to prepare qualified post doctoral trainees for successful scientific careers as independent investigators; to achieve this aim, it will provide intensive training in hypothesis-driven, and hypothesis generating, basic and disease-oriented research in a stimulating and collegial academic environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. Successful MD candidates will have completed residency training as well as a first, clinical, year of Nephrology fellowship training prior to enrolling in This Program. This requirement allows both MD and PhD trainees to devote at least 80% of their time to first-hand experience and training in research under the supervision of an established successful investigator. Research activities will be supplemented by a structured didactic program consisting of weekly journal clubs, research-in-progress meetings, Renal Research Conferences, and formal graduate level course work, tailored to the individual scientific needs of each trainee. For trainees pursuing clinically oriented research, the didactic program is expected to lead to a Master's Degree in Clinical Research. Special strengths of the program include: 1) The diverse skills and research interests of the faculty in timely areas including diabetic nephropathy, chronic kidney disease, gender-based kidney disease, hypertension, ion and solute transport, clinical disorders of electrolyte concentration, transplantation medicine and immunobiology, and protein trafficking and lipid biochemistry. Clinical research interests include patient-oriented outcomes research into effects of cardiovascular disease on renal transplantation, molecular mechanisms of hypertension, and chronic kidney disease care in rural areas, 2) the recently expanded clinical research resources supported by OHSU's Clinical and Translational Science Award (one of the first in the nation), which facilitates training in state-of-the-art clinical investigation; 3) continuing growth of OHSU as a major research-oriented Medical School (ranked 23rd in NIH funded research, 2009), and 4) the structured mentorship and evaluation model that has been developed and will be enumerated herein. A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades, and that this need is critical for continued advancements in human health care. ! PUBLIC HEALTH RELEVANCE: Serious kidney disease affects more than 8 million Americans, causing untold suffering and early death. This program seeks to train academic nephrologists and kidney scientists who will function as independent investigators capable of developing research programs to address the causes of kidney disease and hypertension, and to develop new and improved treatments for it.