Experimental Hematology-Immunology

实验血液学-免疫学

• 批准号: 7083553
• 负责人: DAVID E HARRISON
• 金额: $ 17.39万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7083553
• 关键词: Experimental; Hematology; Immunology

DESCRIPTION (provided by applicant):Scientists at The Jackson Laboratory (TJL) have long seen the need to train a cadre of research scientists in the complexity of the genetic basis of immunological and hematological problems in intact animal model systems. This philosophy, an integral part of the Laboratory's Strategic Plan, has dictated the ongoing expansion of the overall training program at TJL. The Jackson Laboratory requests funding for continuation of its well-established postdoctoral research training program in immunology and hematology. Eleven members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating gene regulation and cell development in hemopoietic and lymphoid cell pathways in the mouse. Experimental work in these genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of immunological and hematological disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. TJL Postdoctoral program (4 trainees). Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results both at in-house interest groups and international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in hematology and immunology at a university, research institution, or in industry. The continued quality of the program is evidenced in part by the fact that all of the trainees supported by this grant in the last reporting period obtained independent fellowships. The primary training facility is TJL, a private, independent research center. TJL is an NIH Basic Cancer Research Center, raises 3 million mice annually, and has held NIH research training grants continuously since 1956.

描述（由申请人提供）：杰克逊实验室（TJL）的科学家长期以来一直认为需要在完整动物模型系统中培养一批研究科学家，了解免疫学和血液学问题遗传基础的复杂性。这一理念，实验室的战略计划的一个组成部分，已经决定了在TJL的整体培训计划的持续扩展。杰克逊实验室要求继续其完善的免疫学和血液学博士后研究培训计划的资金。TJL研究人员的11名成员组成了一个跨学科的实习导师库，他们正在研究小鼠造血和淋巴细胞通路中的基因调控和细胞发育。在这些遗传学定义的动物模型中的实验工作提供了检验关于免疫学和血液学疾病的遗传基础的假设以及模拟新的诊断和治疗方式的机会。这些类型的分析是可能的实验室的特殊近交系，自发和诱导突变小鼠的无与伦比的资源基础的可用性。TJL博士后项目（4名学员）。受训人员将主要精力投入到实验室研究中，并融入TJL研讨会，课程，研讨会和研究兴趣小组。他们需要写研究金申请，并在内部兴趣小组和国际会议上展示他们的成果。他们的进展由一个正式的培训委员会监督，每个委员会的成员都是几个受训者的非正式导师或联络人。完成培训后，参与者将有资格在大学，研究机构或行业中从事血液学和免疫学的创造性，独立研究。在上一个报告所述期间，所有接受该赠款支助的受训人员都获得了独立研究金，这部分证明了该方案的持续质量。主要的培训机构是TJL，一个私人的独立研究中心。TJL是NIH基础癌症研究中心，每年饲养300万只小鼠，自1956年以来一直获得NIH研究培训赠款。