Leveraging CLEERE axial length data to improve myopia treatment

利用 CLEERE 眼轴长度数据改善近视治疗

基本信息

  • 批准号:
    10725732
  • 负责人:
  • 金额:
    $ 43.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-30 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract The dual objectives of myopia research are to prevent myopia onset and, barring that, to reduce myopia progression. The field currently has no way to communicate the effectiveness of the treatments being designed to slow myopia progression other than citing average effects from clinical trials. Clinicians want to be able to demonstrate to children and their parents the impact that a treatment is having on an individual child’s myopia. To do this, percentiles of the expected growth of the eye are necessary. Additionally, the goal of preventing or delaying onset requires being able to predict who will become myopic. Models currently use basic information from one time point to make a simple prediction of more likely than not to develop myopia. Clinicians need an improved model that can assign specific probabilities to individual children in order to properly identify those whose risk of future myopia justifies starting a preventive treatment. The CLEERE Study has the largest longitudinal cohort of ocular development across a variety of race/ethnic groups that will aid in answering these questions. CLEERE provided one of the first reports on the protective effect of time outdoors, but its effects on axial length have yet to be described. Using these data to accomplish the following aims will improve the care of these children. Specific Aim 1: To analyze axial length data and address critical clinical questions in myopia control, namely whom to treat and whether treatment is beneficial. Specific Aim 2: To determine the effect of time spent outdoors/sports activity on axial elongation before and after myopia onset. Specific Aim 3: To improve predictive models by determining whether the trajectory of change in axial length or other ocular components in non-myopic children is a better predictor of the risk of onset of myopia than spherical equivalent refractive error at a single point in time. This NEI Research Grant for Vision-related Secondary Data Analysis (PAR 22-141) will incorporate statistical techniques not routinely employed in vision research to leverage this large existing dataset to more fully explore how to give clinicians the tools they need to effectively treat and manage children’s refractive error.
项目摘要/摘要 近视研究的双重目标是预防近视的发病,并在此基础上减少 近视进展。该领域目前没有办法传达 旨在减缓近视进展的治疗方法,而不是引用 临床试验。临床医生希望能够向孩子和他们的父母展示这种影响 对个别儿童的近视进行的治疗。要做到这一点,预期 眼睛的生长是必要的。此外,预防或推迟发病的目标需要 能够预测谁会变得近视。目前,模型使用的基本信息来自 时点做一个简单的预测,比不预测更容易患上近视。临床医生 需要一种改进的模型,可以将特定的概率分配给各个孩子,以便 正确识别那些未来近视风险足以开始预防性治疗的人。这个 Cleere研究拥有最大的眼睛发育纵向队列,涉及各种 将有助于回答这些问题的种族/民族群体。Cleere提供了第一批 关于户外时间的保护作用的报道,但其对轴长的影响尚未得到报道 描述。使用这些数据来实现以下目标将改善对这些人的护理 孩子们。 具体目标1:分析轴长数据并解决关键的临床问题 近视控制,即治疗谁,治疗是否有益。 具体目标2:确定户外活动/体育活动时间对轴心的影响 近视发病前后的延长。 具体目标3:通过确定 非近视儿童眼轴长度或其他眼部成分的改变更好 近视发病风险的预测因子比球面等效屈光不正 单一时间点。 NEI视觉相关二次数据分析研究助学金(标准杆22-141)将 结合视觉研究中不经常使用的统计技术来利用 现有数据集,以更全面地探索如何为临床医生提供有效 治疗和管理儿童屈光不正。

项目成果

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LISA A Jordan其他文献

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{{ truncateString('LISA A Jordan', 18)}}的其他基金

Vision disorders in adolescents following concussion
青少年脑震荡后视力障碍
  • 批准号:
    10250539
  • 财政年份:
    2020
  • 资助金额:
    $ 43.31万
  • 项目类别:
Vision disorders in adolescents following concussion
青少年脑震荡后视力障碍
  • 批准号:
    10056506
  • 财政年份:
    2020
  • 资助金额:
    $ 43.31万
  • 项目类别:
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control - Data Coordinating Center
近视进展及后果的检验以及软性多焦点隐形眼镜近视控制的机制 - 数据协调中心
  • 批准号:
    10240453
  • 财政年份:
    2014
  • 资助金额:
    $ 43.31万
  • 项目类别:
Soft Bifocal Contact Lens Myopia Control - Data Coordinating Center
软双焦隐形眼镜近视控制 - 数据协调中心
  • 批准号:
    8609208
  • 财政年份:
    2014
  • 资助金额:
    $ 43.31万
  • 项目类别:
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control - Data Coordinating Center
近视进展及后果的检验以及软性多焦点隐形眼镜近视控制的机制 - 数据协调中心
  • 批准号:
    10600988
  • 财政年份:
    2014
  • 资助金额:
    $ 43.31万
  • 项目类别:
Soft Bifocal Contact Lens Myopia Control - Data Coordinating Center
软双焦隐形眼镜近视控制 - 数据协调中心
  • 批准号:
    9254554
  • 财政年份:
    2014
  • 资助金额:
    $ 43.31万
  • 项目类别:
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control - Data Coordinating Center
近视进展及后果的检验以及软性多焦点隐形眼镜近视控制的机制 - 数据协调中心
  • 批准号:
    10382370
  • 财政年份:
    2014
  • 资助金额:
    $ 43.31万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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