Stressors, Sleep, and Cognitive Function among Asian Americans

亚裔美国人的压力源、睡眠和认知功能

• 批准号: 10726414
• 负责人: SUNMIN LEE
• 金额: $ 41.76万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-08 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726414
• 关键词: Affect; African American population; Age; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; American Indians; Asian Americans; Behavioral; Biological; Black Populations; Body mass index; COVID-19; California; Cause of Death; Cessation of life; Chinese; Chronic Disease; Data; Diagnosis; Diagnostic; Discrimination; Disease; Disparity; Drowsiness; Education; Episodic memory; Evaluation; Excess Mortality; Family Caregiver; Health; High Prevalence; Hispanic Populations; Immigrant; Impaired cognition; Incidence; Income; Individual; Inflammation; Intervention; Investigation; Japanese American; Koreans; Life Stress; Link; Longitudinal Studies; Mediating; Medical Records; Medicare; Modeling; Not Hispanic or Latino; Pacific Islander; Parents; Participant; Patient Self-Report; Persons; Polysomnography; Population; Prevalence; Refugees; Reporting; Research; Risk; Risk Factors; Shapes; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Social Processes; Stress; Stressful Event; Subgroup; Symptoms; Testing; Time; Vietnamese; anti-Asian; beneficiary; biopsychosocial; cardiometabolic risk; cognitive function; cognitive testing; dementia risk; design; ethnic minority; experience; health care service utilization; information processing; innovation; memory process; men; mild cognitive impairment; minority stress; mortality; neighborhood disadvantage; perceived discrimination; poor sleep; processing speed; psychologic; psychological distress; racial minority; racism; sex; sleep pattern; sleep quality; stressor; systematic review; tool; traumatic stress; trend; β-amyloid burden

PROJECT SUMMARY / ABSTRACT The Asian American population is rapidly growing and will be the largest immigrant group by 2065. Alzheimer's Disease and Related Dementias (ADRD) is the fastest-growing cause of death for Asian Americans in California, and are likely to increase as the number of U.S. deaths from Alzheimer's disease between 2000-2017 has increased by 145%. During COVID-19, Asian American Medicare beneficiaries with ADRD faced greater excess mortality compared to their non-Hispanic White counterparts. The number of Californian Asian Americans living with ADRD will more than double by 2040, totaling more than 241,000. The ADRD incidence, prevalence, and mortality data for Asian Americans are underestimated because Asian Americans may not report ADRD symptoms unless family caregivers require assistance with behavioral issues, and Asian Americans receive fewer diagnostic evaluations and do not receive timely diagnoses compared to non-Hispanic Whites. Stressful experiences such as discrimination and cumulative life stress increase cognitive impairment or ADRD, however, data are sparse among Asian Americans. Poor sleep has been associated with CI and ADRD through mechanisms such as inflammation increasing β-amyloid burden, although data are lacking in the understudied Asian American population. This study builds on the biopsychosocial model of health and disease, which posits that biological, psychological, and social processes interactively shape health and illness within individuals, and subgroups of the population. Data for the proposed study will be collected as a part of the parent longitudinal R01 study examining associations among immigrant stressors, sleep, and cardiometabolic risks in 750 Chines, Korean, and Vietnamese Americans residing in Southern California. In the proposed supplement study, we will add a 10- minute global cognitive function examination tool (the Montreal Cognitive Assessment (MoCA)) to the parent study and collect data from 50 Chinese, 50 Korean, and 50 Vietnamese participants who are 60 ≥ years old and already participating in the parent study. This innovative supplement study will be one of the first studies to examine the interplay of immigrant stressors, sleep, and cognitive function among Asian Americans. Findings from this study will contribute to designing a larger-scale longitudinal study to examine in-depth causal associations and identify modifiable targets for intervention to reduce sleep and ADRD disparities in understudied Asian Americans. Relevance to ADRD: Both specific aims of the proposed application focus on examining predictors of cognitive function using a validated assessment for detecting mild cognitive impairment, a precursor to ADRD.

项目摘要/摘要 亚裔美国人人口正在迅速增长，到2065年将成为最大的移民群体。阿尔茨海默氏症 疾病及相关痴呆症(ADRD)是加州亚裔美国人死亡增长最快的原因， 随着2000-2017年间美国死于阿尔茨海默病的人数增加，这一数字可能还会增加 增长了145%。在新冠肺炎期间，患有ADRD的亚裔美国人医疗保险受益人面临更大的过剩 死亡率与非西班牙裔白人相比。居住在加州的亚裔美国人的数量 到2040年，ADRD将增加一倍以上，总数超过241,000人。ADRD的发生率、流行率和 亚裔美国人的死亡率数据被低估了，因为亚裔美国人可能不会报告ADRD 症状，除非家庭照顾者在行为问题上需要帮助，以及亚裔美国人接受 与非西班牙裔白人相比，诊断评估更少，没有收到及时的诊断。 有压力的经历，如歧视和累积的生活压力会增加认知障碍或ADRD， 然而，亚裔美国人的数据很稀少。睡眠不良通过以下途径与CI和ADRD有关 炎症等增加β-淀粉样蛋白负荷的机制，尽管在研究不足的人中缺乏数据 亚裔美国人。 这项研究建立在健康和疾病的生物心理社会模型的基础上，该模型假设， 社会进程交互作用地塑造个人和人口亚群的健康和疾病。 拟议研究的数据将作为母公司纵向R01研究检查的一部分进行收集 750名中国人、韩国人和美国人中移民应激源、睡眠和心脏代谢风险之间的关系 居住在南加州的越南裔美国人。在建议的补充研究中，我们会加入10- 对父母的微小全球认知功能检查工具(蒙特利尔认知评估(MoCA)) 研究和收集来自50名中国人、50名韩国人和50名越南人的数据，这些人年龄在60岁，≥和 已经参加了家长研究。 这项创新性的补充研究将是第一批考察移民应激源相互作用的研究之一， 亚裔美国人的睡眠和认知功能。这项研究的发现将有助于设计 更大规模的纵向研究，以检查深入的因果关系并确定可修改的目标 干预以减少研究不足的亚裔美国人的睡眠和ADRD差异。 与ADRD的相关性：拟议应用的两个具体目标都侧重于检查认知预测因素 使用有效的评估来检测轻度认知障碍，这是ADRD的前兆。