The overlap of speech production and verbal working memory

言语产生和言语工作记忆的重叠

• 批准号: 10735031
• 负责人: Gregory B Cogan
• 金额: $ 48.26万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735031
• 关键词: Address; American; Anatomy; Apraxias; Architecture; Behavior; Behavioral; Brain; Clinic; Clinical; Clinical Research; Cognition; Data; Dissociation; Electric Stimulation; Electrocorticogram; Electrodes; Environment; Epilepsy; Etiology; Functional disorder; Grain; Human; Implanted Electrodes; Inferior; Knowledge; Language; Language Development Disorders; Language Disorders; Lesion; Link; Location; Maintenance; Maps; Measures; Methods; Modeling; Modification; Monitor; Motor; Motor Cortex; Neuroanatomy; Operative Surgical Procedures; Parietal; Patients; Population; Production; Property; Recovery; Rehabilitation therapy; Research; Resolution; Role; Sampling; Series; Short-Term Memory; Signal Transduction; Site; Specificity; Speech; Speech Disorders; Stroke; Symptoms; System; Techniques; Temporal Lobe; Testing; Time; Translational Research; Update; clinical care; cognitive process; density; design; flexibility; insight; memory process; neural; neural circuit; neuromechanism; neurosurgery; neurotransmission; novel; novel therapeutic intervention; phonology; response; sound; speech recognition; stroke rehabilitation; stroke-induced aphasia; temporal measurement; verbal

Abstract To enable the expression of ideas in everyday conversation, our brain must hold on to speech information for short periods of time in verbal working memory (vWM). This is particularly important for everyday conversation that takes place in chaotic environments: Plans for speaking change quickly, and the brain has to adapt to these changes. Previous models of vWM, have suggested that vWM is anatomically and functionally discrete, with only indirect interactions with speech production. Evidence from lesions following strokes however, have shown a wide range of speech production deficits that are also associated with problems with vWM, arguing against a strong dissociation between speech production and vWM. We propose instead that vWM is integrated in the speech production planning system, sharing an anatomical and functional substrate. To study this overlap, we propose to examine neural responses associated with this functional overlap through a population of neurosurgical patients who as part of their clinical care have electrodes implanted directly in their brain, giving us a unique opportunity to study the human brain at a greater resolution that has been done in the past. We will leverage this access to address the following questions: 1) Does speech production and vWM overlap in the brain? 2) What kind of information is held when planning for speech production? 3) What motor features are shared between speech production and vWM? We will use a series of tasks that are designed to separate out the role of vWM for different speech production components and measure human brain responses using direct brain recordings, including high density electrodes that have unprecedented spatial resolution (<1 mm, up to 1024 electrodes for a 10 x increase in sampling). Understanding this basic cognitive process and their role in everyday language use will lead to more targeted approaches to help the over 1 million Americans who suffer from stroke-induced aphasia.

抽象的 为了在日常对话中启用思想的表达，我们的大脑必须坚持使用语音信息 言语工作记忆（VWM）中的短时间。这对于日常对话特别重要 这发生在混乱的环境中：迅速讲话的计划，大脑必须适应这些 更改。 VWM的先前模型表明，VWM在解剖学和功能上是离散的，仅具有 与语音产生的间接互动。然而，来自中风后病变的证据已显示出 与VWM问题也相关的各种语音生产缺陷，反对 语音产生与VWM之间的强烈解离。相反，我们建议VWM集成 语音生产计划系统，共享一个解剖和功能性基材。为了研究这个重叠，我们 建议检查与该功能重叠相关的神经反应 作为临床护理一部分的神经外科患者，电极直接植入了大脑 我们是一个独特的机会，可以通过过去做出的更大的解决方案来研究人脑。我们将 利用此访问来解决以下问题：1）在 脑？ 2）在计划语音生产时持有什么样的信息？ 3）什么是电机功能 语音制作和VWM之间共享？我们将使用一系列旨在分开的任务 VWM在不同语音生产组件中的作用，并使用直接测量人脑反应 大脑记录，包括空间分辨率前所未有的高密度电极（<1 mm，直至 1024个电极，以增加抽样的10 x）。了解这个基本的认知过程及其在 日常语言使用将导致更有针对性的方法，以帮助超过100万遭受苦难的美国人 来自中风引起的失语症。