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Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

体位性心动过速综合征 (POTS) 的多模态深度表型分析

基本信息

批准号：
10733708
负责人：
BENJAMIN D LEVINE
金额：
$ 168.44万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733708
关键词：
Acute Affect Agreement American Ancillary Study Biochemical Biological Biological Specimen Banks Blood Tests Blood Volume Blood specimen Cardiac Characteristics Chronic Chronic Disease Classification Clinical Cluster Analysis Collaborations Complex Data Data Set Derivation procedure Diagnostic Evaluation Exercise Exercise Test Funding Future Gases Genomics Goals Health Heart Immune system Immunologic Markers Immunophenotyping Impairment Individual Investigation Laboratories Measures Metabolism Modality Modification Molecular Monitor Morbidity - disease rate Muscle Normal Range Outcome Outcome Measure Participant Patients Phenotype Physical activity Physiological Postural Orthostatic Tachycardia Syndrome Procedures Proteomics Protocols documentation Publishing Quality of life Regulation Reporting Research Research Personnel Resolution Skeletal Muscle Structure Symptoms Syndrome Testing Therapeutic Training Transducers United States National Institutes of Health clinical database clinical phenotype clinically relevant cohort comparative conditioning design diagnostic tool disabling disease disabling symptom exercise intensity exercise intolerance exercise program exercise training falls fitness follow-up hemodynamics improved individualized medicine innovation metabolomics multimodal data multimodality novel novel therapeutics orthostatic intolerance predicting response productivity loss prognostic value programs recruit research study response standard of care

项目摘要

Project summary Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different subtypes are not known. For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program. Our research study will examine the different types of POTS by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise. This study will be the first to define the full picture of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future POTS research.

项目摘要体位性心动过速综合征（POTS）是一种引起致残症状的慢性疾病，生产力的巨大损失。并不是所有的POTS患者都是一样的，其病因和意义也各不相同亚型未知。例如，一些患者可能具有免疫系统的异常调节，其他人可能在他们的肌肉对活动的反应方面有问题。运动训练已被证明是一种虽然这是一种有益的治疗POTS的方法，但大约25%的患者无法完成锻炼计划。我们的研究将通过系统和全面的研究，不同的患者群体。这将包括仔细评估症状，血液检查和心脏结构以及对肌肉运动反应的详细分析。这项研究将是第一个定义全貌不同的POTS子类型以及这些子类型之间的关系。我们的研究将使临床医生更好地评估和个体化治疗，并将指导未来的POTS研究。