A Diet Intervention Study To Mitigate Fatigue Symptoms And To Improve Muscle And Physical Function In Older Adults With Post-Acute COVID-19 Syndrome

近五分之一的美国成年人谁幸存的冠状病毒病（COVID-19）仍然患有 急性COVID-19后综合征（PACS），42是一种复杂的全身性疾病，表现为疲劳和肌肉 严重限制一项或多项主要生活活动的弱点。35 - 41，92对于老年人， 饮食不足可能会加剧他们的健康恶化，加速他们的身体机能下降。43- 44营养研究表明，全饮食包括抗炎活性高的食物，例如， 全谷物、水果、蔬菜和富含欧米伽-3脂肪酸的食物大大减少了与疾病相关的疲劳， 49 -50名遵循《美国人膳食指南》（DGA）的美国成年人， 更有可能保持肌肉的握力比那些谁没有。17由于疲劳和身体功能， 相互关联，“全饮食方法”56，61，62与DGA 60保持一致，重点关注高抗营养素 炎症活动可能是改善老年人PACS恢复的有效策略。这 该项目提出，在16周的随机对照饮食干预中， 饮食方法"减轻与营养有关的PACS症状，例如，疲劳和肌肉无力， 将通过生物标志物探索潜在的机制。样本将包括50岁的男性和女性 岁或以上的PACS患者，包括代表性不足的少数民族（50%非西班牙裔黑人）。在基线时， N=56名合格的参与者将被随机分配到：1）新DGA后的饮食干预， 通过食物和/或补充剂关注抗炎活性高的营养素（例如，维生素D，欧米茄-3， 和乳清）;或2）注意力控制。 目标1。在一项为期16周的随机对照试验中，我们将检查全饮食方法的效果 (WDA)健康饮食指数（HEI）和疲劳与PACS成人的注意力控制相比。 目标2.评估WDA后饮食干预对肌肉质量、力量和 PACS患者的身体功能与注意力控制的比较。 目标3。目的：探讨运动训练减轻疲劳，改善肌肉和身体机能的机制。 检查从基线到16周的营养和炎症生物标志物的变化。 建议的饮食干预，以减轻老年人的PACS是一个可行的研究相关的公众 健康马里兰州巴尔的摩大学提供了一个独特的机会，由多学科的培训， 导师团队，他们是临床试验、肌肉、身体功能、营养、老年医学、统计学和 COVID-19成功进行这项研究。这些发现可以转化为一种新的战略， 疲劳和身体功能下降。K 01奖将为我提供所需的培训， 成为饮食试验的独立调查员，以推进营养和衰老领域，同时获得 在领导和指导方面的技能和经验，以启动我的学术生涯。

Nearly one in five American adults who survived the coronavirus disease (COVID-19) are still suffering from post-acute COVID-19 syndrome (PACS),42 a complex systemic disease manifests in fatigue and muscle weakness that substantially limits one or more major life activities.35-41,92 For older adults, having PACS coupled with an inadequate diet may compound their health deterioration and hasten their physical function decline. 43- 44 Nutritional studies demonstrate that a whole diet comprises foods high in anti-inflammatory activities, e.g., whole grains, fruits, vegetables, and omega-3 fatty acid-rich foods substantially reduce disease-related fatigue, likely by reducing inflammation.49-50 U.S. adults who followed the Dietary Guidelines for Americans (DGA) were more likely to preserve muscle grip strength than those who did not.17 Since fatigue and physical function are interrelated, a ‘Whole-Diet Approach’56,61,62 aligned with the DGA60 with a focus on nutrients high anti- inflammatory activities may be an effective strategy to ameliorate recovery from PACS in older adults. This project proposes to examine, in a 16-week randomized-controlled dietary intervention, the effect of the ‘Whole- Diet Approach’ on mitigating symptoms of PACS related to nutrition, e.g., fatigue and muscle weakness and will explore the underlying mechanisms via biomarkers. The sample will comprise men and women aged 50 years or older with PACS, including underrepresented minorities (50% Non-Hispanic-Blacks). At baseline, N=56 eligible participants will be randomized to either: 1) a dietary intervention following the new DGA with a focus on nutrients high in anti-inflammatory activities via foods and or supplements (e.g., vitamin D, omega-3, and whey); or 2) attention control. Aim 1. In a 16-week, randomized-controlled trial, we will examine the effect of the Whole-Diet Approach (WDA) on the Healthy Eating Index (HEI) and fatigue compared to attention control in adults with PACS. Aim 2. To assess the impact of the dietary intervention following the WDA on muscle mass, strength, and physical function compared to attention control in adults with PACS. Aim 3. To explore the mechanism of decreased fatigue and improved muscle and physical function by examining changes in nutritional and inflammatory biomarkers from baseline to 16 weeks. The proposed dietary intervention to attenuate PACS in older adults is a feasible study relevant to public health. The University of Maryland Baltimore provides a unique opportunity to be trained by a multidisciplinary team of mentors who are experts in clinical trials, muscle, physical function, nutrition, geriatrics, statistics, and COVID-19 to conduct this study successfully. The findings can be translated into a new strategy to counteract fatigue and physical function decline following PACS. The K01 Award will provide me with the training I need to become an independent investigator in dietary trials to advance the field of nutrition and aging while gaining the skills and experience in leadership and mentorship to launch my career in academia.