Multidisciplinary sickle cell disease obstetrics care program in Ghana: Non-academic vs.Academic Hospital (Pilot Study)

加纳多学科镰状细胞病产科护理计划：非学术医院与学术医院（试点研究）

• 批准号: 10734007
• 负责人: Eugenia Vicky Asare
• 金额: $ 8.53万
• 依托单位: COLLEGE OF HEALTH SCIENCES, UNIVERSITY OF GHANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-11 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734007
• 关键词: Acute Pain; Africa; Africa South of the Sahara; Award; Caring; Case Series; Cause of Death; Certification; Cessation of life; Clinic; Clinical; Communication; Complication; Consolidated Framework for Implementation Research; Data Collection; Diagnosis; Discipline of obstetrics; Education; Evidence based practice; Failure; Feasibility Studies; Fetal Monitoring; Focus Groups; Future; General Practitioners; Ghana; Goals; Guidelines; Health Personnel; Hematologist; Hematology; Hospital Administrators; Hospitals; Hybrids; Institution; Intervention; Interview; Joints; Knowledge; Laboratory Scientists; Life; Life Expectancy; Live Birth; Location; Maternal Mortality; Medical; Mentors; Midwife; Needs Assessment; Northern Europe; Odds Ratio; Perception; Perinatal mortality demographics; Physicians; Pilot Projects; Pregnancy; Pregnant Women; Protocols documentation; Provider; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Relative Risks; Reporting; Research Design; Resource-limited setting; Resources; Risk Reduction; Scientist; Series; Sickle Cell Anemia; Site; Structure; System; Teaching Hospitals; Technology; Testing; Training and Education; Woman; Work; acute chest syndrome; adjudication; cohort; compare effectiveness; evidence base; experience; hospital care; hybrid type 1 study; implementation process; implementation/effectiveness; improved; low and middle-income countries; maternal morbidity; mortality; multidisciplinary; obstetric care; pediatrician; perinatal morbidity; prevent; programs; prospective; service delivery; skill acquisition; tertiary care

With increasing life expectancy in Africa, pregnancy has become an emerging life-threatening complication in SCD women. In low and middle-income countries, the odds ratio of maternal death associated with SCD is 22.81, 95% CI 14.67–35.46.1 From 2012-2014, the Obstetrics Department, Korle-Bu Teaching Hospital (KBTH), Accra, Ghana, established an obstetrician-led SCD Obstetrics (OB) clinic. The Institutional maternal mortality for SCD over these three years (2012-2014) was approximately 12%. In January 2015, a multidisciplinary SCD OB team was established. The team conducted a combined retrospective/ prospective case series of all maternal deaths in women with SCD at KBTH over seven years (2010-2016).2 This retrospective data collection highlighted failures and challenges to delivering improved care. Acute chest syndrome, preceded by acute pain episodes, was the leading cause of death in nearly 87% of women.2 In May 2015, the team implemented a joint obstetrics/ hematology clinic, instituted close maternal and fetal monitoring, and implemented clinical guidelines/ protocols. In addition, the SCD OB team established a weekly communication system to adjudicate the management of challenging cases. These interventions resulted in an 89.1% risk reduction in maternal mortality (from 10,791 to 1,176 deaths per 100,000 live births; p=0.007) over 13 months.3 Since initiating our multidisciplinary SCD OB program, we have consistently decreased maternal mortality in this cohort by approximately 90% compared to before the team was established.4,5 This physician-mentored application aims to conduct an Effectiveness-Implementation Feasibility Study to extend our results of decreasing maternal mortality from an academic hospital to a non- academic hospital setting in Accra, Ghana with a current maternal mortality rate of 5,940 deaths/ 100,000 live births in SCD women. Over five years, the applicant will acquire the skills to use the Consolidated Framework for Implementation Research (CFIR)6 and the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance)7 to inform the stages of the study. The applicant will test the hypothesis that " In a before and after study design, the applicant will test the hypothesis that multi- disciplinary care and task-shifting in a non-academic hospital for pregnant women with SCD will have an 80% relative risk reduction in death compared to the mortality rate in the same hospital before the multi-disciplinary medical care." The specific aims for this mentored award are: 1) Identify contextual determinants (barriers/ facilitators) that influence the adaptability of the evidence-based practice for establishing a multidisciplinary SCD OB team as an intervention in the non-academic hospital, including the implementation process (Years 1-2); 2) Build capacity for a multidisciplinary SCD OB program in a non- academic hospital (Years 3-5), and 3) Conduct a Hybrid type 1 feasibility study comparing the effectiveness of a task-shifted multidisciplinary SCD OB program in a non-academic site (Years 3-5).

随着非洲预期寿命的增加，怀孕已成为一种新出现的危及生命的并发症 在SCD女性中。在低收入和中等收入国家，与SCD相关的孕产妇死亡的比值比 是22.81，95%CI 14.67-35.46.1 2012-2014年，库尔勒市教学医院产科 （KBTH），阿克拉，加纳，建立了一个产科医生领导的SCD产科（OB）诊所。机构产妇 这三年（2012-2014年）SCD的死亡率约为12%。2015年1月，A 成立了多学科SCD OB团队。该团队进行了一项回顾性/前瞻性联合研究， KBTH七年（2010-2016年）所有SCD女性孕产妇死亡病例系列。2 回顾性数据收集凸显了提供更好护理的失败和挑战。急性胸部 在近87%的女性中，急性疼痛发作之前的综合征是导致死亡的主要原因。 2015年5月，该团队实施了产科/血液学联合诊所，建立了密切的孕产妇和胎儿 监测，并实施临床指南/方案。此外，SCD OB团队建立了一个 每周沟通系统，以裁定具有挑战性的案件的管理。这些干预措施 使孕产妇死亡率风险降低89.1%（从每100，000例活产死亡10，791例降至1，176例; p=0.007）超过13个月。3自从启动我们的多学科SCD OB计划以来，我们一直 与团队之前相比，该队列的孕产妇死亡率降低了约90%， 4，5这一由医生指导的应用程序旨在执行一项强制性实施 将我们降低孕产妇死亡率的成果从学术医院推广到非学术医院的可行性研究 加纳阿克拉的一家学术医院，目前孕产妇死亡率为5，940/100，000 SCD妇女的活产。在五年内，申请人将获得使用综合 实施研究框架（CFIR）6和RE-AIM框架（范围，有效性， 采用、实施和维护）7，以告知研究的各个阶段。申请人将测试 假设“在之前和之后的研究设计中，申请人将检验多个 在非学术性医院对SCD孕妇进行纪律护理和任务转移， 与治疗前同一医院的死亡率相比， 多学科的医疗服务。“这个指导奖的具体目标是：1）确定背景 影响循证实践适应性的决定因素（障碍/促进因素）， 建立多学科SCD OB团队，作为非学术医院的干预措施，包括 实施过程（第1-2年）; 2）在非政府组织中建立多学科SCD OB计划的能力， 学术医院（3-5年），以及3）进行混合1型可行性研究，比较有效性 任务转移多学科SCD OB计划在非学术网站（年3-5）。