GUMC Zebrafish Shared Resource Aquatic Habitat Modernization Project

GUMC斑马鱼共享资源水生栖息地现代化项目

• 批准号: 10734150
• 负责人: ERIC GLASGOW
• 金额: $ 31.73万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10734150
• 关键词: Academic Medical Centers; Aging; Animal Experimentation; Animals; Award; Biological Models; Biomedical Research; Breeding; Cancer Model; Comprehensive Cancer Center; Consult; Dedications; Developmental Biology; Dose; Education; Education and Outreach; Electricity; Embryo; Ensure; Equipment; Event; Expenditure; Film; Filtration; Fishes; Floor; Funding; Goals; Grant; Habitats; Health; Health Services Accessibility; Housing; Image; Immunology; Institution; International; Knowledge; Life Support Systems; Longevity; Maintenance; Malignant Neoplasms; Medical Research; Mission; Modeling; Modernization; Monitor; NCI Center for Cancer Research; Neurobiology; Neurologic; Neurosciences; Oncology; Organism; Persons; Phenotype; Plumbing; Positioning Attribute; Printing; Pump; R24; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Rotation; Services; Site; Source; Standardization; Stress; Students; System; Technology; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Update; Water; Work; Workload; Zebrafish; career; community center; design; experimental study; improved; medical schools; member; model organism; mutant; oocyte quality; operation; outreach; professor; programs; screening; sensor; wasting; water quality; wireless fidelity

Abstract: The Georgetown University Medical Center (GUMC) Zebrafish Shared Resource (ZSR), a member of the Lombardi Comprehensive Cancer Center (LCCC) Research Consortium, provides expertise and ready access to zebrafish as a model for biomedical research to the GUMC community. Under the direction of Dr. Eric Glasgow, Assistant Professor of Oncology, and with assistance from Dr. Matthew Swift, the ZSR has provided research services and support for dozens of investigators, both internal and external, to incorporate zebrafish models into their research. The ZSR was the first of its kind to offer full-service access to zebrafish models anywhere and is an essential part of GUMC fulfilling its mission to offer a full range of state-of-the-art research services expected of a top national academic medical center. The current aquatic life support system utilized by the facility was built in 2004. Due to maintenance by and expertise of the ZSR director, the facility has far outlasted its projected useful lifespan, as well as that of the company that built it, Aquatic Habitats. A complete upgrade of the current system is necessary in order to maintain and enhance the efficiency and standardization of our zebrafish husbandry. A modern, technologically advanced aquatic animal system equipped with water quality assessment sensors will increase the housing capacity, doubling the number fish; decrease the husbandry workload increasing operational efficiencies; increase sustainability by saving energy, water, and materials; standardize husbandry conditions; and improve the consistency and quality of egg laying. These improvements will increase research capacity of the ZSR, as well as improving the rigor, reproducibility, and translatability of our zebrafish-based research. We are applying for this R24 grant in order to purchase a new aquatic system that will accomplish these goals and allow GUMC to expand on its position as one of the leaders in utilizing the zebrafish model for research into oncology, immunology, neuroscience, and developmental biology. If awarded, the grant will cover necessary expenditures related to the purchase of the new system and required support equipment.

翻译后摘要：乔治城大学医学中心（GUMC）斑马鱼共享资源（ZEJR），一个成员 伦巴第综合癌症中心（LCCC）研究联盟，提供专业知识和准备 将斑马鱼作为生物医学研究的模型提供给GUMC社区。在博士的指导下。 Eric格拉斯哥，肿瘤学助理教授，在Matthew Swift博士的协助下， 为数十名内部和外部调查人员提供了研究服务和支持， 将斑马鱼模型引入他们的研究。该公司是第一家为斑马鱼提供全方位服务的公司 任何地方都可以使用模型，并且是GUMC履行其提供全系列最先进产品的使命的重要组成部分 一个顶级的国家学术医疗中心的研究服务。目前的水生生物支持系统 该设施建于2004年。由于维修和专业知识的主任，该设施 已经远远超过了它的预期使用寿命，以及建造它的公司，水产养殖。一 为了维持和提高效率， 斑马鱼养殖标准化。一个现代化的、技术先进的水生动物系统 配备水质评估传感器将增加住房容量，使鱼类数量增加一倍; 减少畜牧业工作量，提高运营效率;通过节约能源提高可持续性， 规范饲养条件，提高产蛋的一致性和质量。 这些改进将提高该研究所的研究能力，并提高其严谨性，可重复性， 和可翻译性。我们正在申请这项R24赠款，以购买 新的水生系统，将实现这些目标，并允许GUMC扩大其地位，作为一个 利用斑马鱼模型进行肿瘤学、免疫学、神经科学和 发育生物学如获拨款，资助将用以支付购买 新系统和所需的支持设备。