Odor Coding in the Dorsal Tenia Tecta

背侧腱索的气味编码

• 批准号: 10735102
• 负责人: Adam Kabir Dewan
• 金额: $ 37.32万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-07 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735102
• 关键词: Acceleration; Anatomy; Animals; Anxiety Disorders; Atlases; Behavior; Biological Assay; Brain; Brain region; Cells; Chemicals; Code; Communities; Data; Dorsal; Electrophysiology (science); Emotional; Fiber; Freezing; Glutamates; Health; Hippocampus; Human; Image; Individual; Investigation; Mammals; Maps; Memory; Mental Health; Methods; Mus; Neurons; Odors; Olfactory Cortex; Olfactory Pathways; Output; Perception; Play; Population; Post-Traumatic Stress Disorders; Process; Property; Psyche structure; Psychosocial Stress; Quality of life; Rattus; Research; Role; Sensory; Signal Transduction; Smell Perception; Source; Stimulus; Stream; Stress; Structure; Techniques; Transgenic Mice; biological adaptation to stress; conditioned fear; density; excitatory neuron; experience; experimental study; food quality; inhibitory neuron; insight; microendoscope; neural; olfactory bulb; olfactory stimulus; optogenetics; receptor; response; restraint stress; segregation; sensory system

PROJECT SUMMARY The formation of a percept results from the processing of sensory information across a network of brain regions, each contributing uniquely to perception. Thus, to understand the mechanisms by which the brain encodes sensory information, we must study each component of the network. Olfactory perception is dependent upon a distributed network of processing centers, which are connected in serial and parallel manners. Odor information is organized into receptor-specific channels mapped onto the olfactory bulb. These singular streams of information are broadly projected by mitral/ tufted cells to multiple cortical structures. This direct, parallel input is thought to allow each region to maintain a representation of the stimulus and play a unique role in odor perception. While putative functions have been ascribed to several olfactory cortical regions, the importance of the dorsal tenia tecta for olfactory perception remains a mystery. Here, we propose to examine the connectivity, odor coding, and function of this region. Specific Aim 1 will examine the afferent and efferent connections of the dorsal tenia tecta. Specific Aim 2 will characterize the odor tuning properties of dorsal tenia tecta neurons. Specific Aim 3 will assess the contribution of this region for olfactory perception. Achieving these aims will provide new insight into how odorant features are encoded and mapped within the brain and elucidate the function of this enigmatic brain region for olfactory perception.

项目总结