Developing MBSR for Application in Alcoholism Treatment

描述（由申请人提供）：酒精依赖者开始戒酒后，酗酒复发是常见的结果。这种旧病复发主要发生在涉及个人或人际压力的情况下。作为回应，本申请（根据 NIAAA 的“行为和综合治疗发展计划”计划公告 {PA06-486} 提交）建议在酗酒治疗中采用、应用和评估正念减压（MBSR），这是一种行之有效的减压干预措施。 MBSR强调发展独立观察和对意识内容的认识，已被证明可以有效提高应对压力的能力以及增强应对能力和心理健康。然而，文献中没有对照临床研究评估MBSR对酒精依赖者的独特作用。该项目将分两个阶段进行。在第一阶段（第 1a 阶段活动），用于进行基于小组的 MBSR 的 8 次治疗手册将进行调整，以用于酒精依赖男性和女性的标准化 10 次治疗（TAU）。在第二阶段（第 1b 阶段活动）中，将进行一项试点临床试验，以检查在 TAU 中添加 MBSR 对酒精依赖门诊患者的效果。参加 TAU MBSR 的患者的结果将与接受 TAU 加上一系列健康和生活方式讲座 (TAU HLL) 的患者的结果进行比较。这项研究的积极结果将为更大规模的第二阶段对照临床试验奠定基础，以进一步评估酗酒治疗中的 MBSR 并确定其作用机制 MBSR 可以发挥作用来实现这些好处。这项研究的长期目标是减少治疗后饮酒的复发，这将为接受酒精依赖治疗的人带来显着的健康益处。

DESCRIPTION (provided by applicant): Relapses to drinking are common outcomes following the initiation of abstinence among alcohol dependent individuals. Such relapses predominantly occur in situations involving either intrapersonal or interpersonal stress. In response, the present application (submitted under NIAAA's "Behavioral and Integrative Treatment Development Program" Program Announcement {PA06-486}) proposes the adaptation, application, and evaluation of Mindfulness-based Stress Reduction (MBSR), a well-established stress reduction intervention, in alcoholism treatment. MBSR, with its emphasis on the development of detached observation and awareness of the contents of consciousness, has been shown to be efficacious in increasing the ability to cope with stress and in enhancing coping and psychological well-being. However, there are no controlled clinical studies in the literature evaluating the unique effects of MBSR among persons with alcohol dependence. The project will be conducted in two phases. In Phase I (Stage 1a activity), an 8- session treatment manual for conducting group-based MBSR will be adapted for use in the context of a standardized 10-session treatment-as-usual (TAU) for alcohol dependent men and women. In Phase II (Stage 1b activity), a pilot clinical trial will be conducted to examine the effects of adding MBSR to TAU for alcohol dependent outpatients. The outcomes of patients participating in TAU + MBSR will be compared to the outcomes for patients receiving TAU plus a series of Health and Lifestyle Lectures (TAU + HLL). Positive findings emerging from this research will serve as foundation for a larger, Stage 2 controlled clinical trial to further evaluate MBSR in alcoholism treatment and to determine the mechanisms of action by which MBSR may operate to effect such benefits. The long-term goal of this research is to decrease relapse to drinking following treatment, which will provide significant health benefits to persons being treated for alcohol dependence.