Developing MBSR for Application in Alcoholism Treatment

描述（由申请人提供）：复发饮酒是酒精依赖者开始戒酒后的常见结果。这种复发主要发生在涉及自我或人际压力的情况下。作为响应，本申请（根据NIAAA的“行为和综合治疗发展计划”计划公告{PA 06 -486}提交）提出了在酒精中毒治疗中调整、应用和评估基于正念的减压（MBSR），一种成熟的减压干预。正念减压疗法强调发展独立观察和意识内容的意识，已被证明在提高科普压力的能力和增强应对能力和心理健康方面是有效的。然而，在文献中没有对照临床研究评估MBSR在酒精依赖者中的独特作用。该项目将分两个阶段进行。在第一阶段（第1a阶段活动），一个用于进行基于小组的正念减压疗法的8个疗程的治疗手册将被改编用于酒精依赖男性和女性的标准化10个疗程的常规治疗（TAU）。在第二阶段（第1b阶段活动），将进行一项试点临床试验，以检查在TAU中加入MBSR对酒精依赖门诊患者的影响。参与TAU + MBSR的患者的结局将与接受TAU+一系列健康和生活方式讲座（TAU + HLL）的患者的结局进行比较。这项研究的积极发现将为更大规模的第二阶段对照临床试验奠定基础，以进一步评估MBSR在酒精中毒治疗中的作用，并确定其作用机制， 正念减压疗法可以发挥作用以实现这些益处。这项研究的长期目标是减少治疗后饮酒的复发，这将为正在接受酒精依赖治疗的人提供显着的健康益处。

DESCRIPTION (provided by applicant): Relapses to drinking are common outcomes following the initiation of abstinence among alcohol dependent individuals. Such relapses predominantly occur in situations involving either intrapersonal or interpersonal stress. In response, the present application (submitted under NIAAA's "Behavioral and Integrative Treatment Development Program" Program Announcement {PA06-486}) proposes the adaptation, application, and evaluation of Mindfulness-based Stress Reduction (MBSR), a well-established stress reduction intervention, in alcoholism treatment. MBSR, with its emphasis on the development of detached observation and awareness of the contents of consciousness, has been shown to be efficacious in increasing the ability to cope with stress and in enhancing coping and psychological well-being. However, there are no controlled clinical studies in the literature evaluating the unique effects of MBSR among persons with alcohol dependence. The project will be conducted in two phases. In Phase I (Stage 1a activity), an 8- session treatment manual for conducting group-based MBSR will be adapted for use in the context of a standardized 10-session treatment-as-usual (TAU) for alcohol dependent men and women. In Phase II (Stage 1b activity), a pilot clinical trial will be conducted to examine the effects of adding MBSR to TAU for alcohol dependent outpatients. The outcomes of patients participating in TAU + MBSR will be compared to the outcomes for patients receiving TAU plus a series of Health and Lifestyle Lectures (TAU + HLL). Positive findings emerging from this research will serve as foundation for a larger, Stage 2 controlled clinical trial to further evaluate MBSR in alcoholism treatment and to determine the mechanisms of action by which MBSR may operate to effect such benefits. The long-term goal of this research is to decrease relapse to drinking following treatment, which will provide significant health benefits to persons being treated for alcohol dependence.