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Dietary Energy Restriction and Metabolic Aging in Humans

人类膳食能量限制和代谢衰老

基本信息

批准号：
7457983
负责人：
SUSAN B ROBERTS
金额：
$ 31.91万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-15 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7457983
关键词：
Accounting Address Adherence Adverse event Age Aging Basal metabolic rate Behavioral Blood Body Composition Body Temperature Body Weight Body mass index Bone Density Caloric Restriction Cardiopulmonary Control Groups Counseling Development Diet Dietary Factors Dietary Fats Dietary Fiber Dietary intake Disease Dose Drops Energy Intake Energy Metabolism Energy-Generating Resources Enrollment Ensure Excretory function Exercise Fasting Fatty acid glycerol esters Food Food and Beverages Glucose Glycemic Index Goals Guidelines Health Hemoglobin Human Hunger Incidence Individual Instruction Insulin Intake Intervention Label Life Liquid substance Matched Group Measurement Metabolic Monitor Moods Morbidity - disease rate Numbers Nutrient Obesity Outcome Overweight Oxidative Stress Patient Self-Report Physical activity Pilot Projects Randomized Range Rate Recommendation Research Satiation Testing Thyroid Gland Thyroid Hormones Time Treatment Protocols Vitamin K Water Woman aged cognitive function day feeding fitness immune function kinetosome men mortality programs reproductive hormone response therapy design urinary

项目摘要

Reducing morbidity and delaying mortality are recognized as major goals of aging research, and are addressed by this proposal to conduct a 2-year human caloric restriction (CR) intervention. A 1-year pilot study will be conducted in 32 overweight men and women to develop an effective CR regimen when fed at 70% of energy requirements determined at baseline. As part of this pilot we will refine all aspects of a CR intervention, including exercise and behavioral counseling, and will obtain necessary information on outcome variability with which to perform power calculations for the main study. Subjects will be randomized to two dietary regimens with different levels of dietary fat and glycemic index (GI) (20% fat and moderate GI vs. 35% fat and low GI) and dietary compliance and key outcome measurements will be determined at 5 periods throughout the year. Dietary factors such as dietary variety, liquid sources of energy, and dietary fiber will then be taken into account in the design of the interventions. Following identification of an effective CR regimen, a randomized 2- year intervention will be conducted in 117 overweight men and women fed 70%, 80% or 100% of energy requirements determined at baseline. The hypothesis will be tested that, compared to control subjects fed 100% of baseline energy requirements. The parameters to be evaluated will include immune function, oxidative stress, fasting insulin, hemoglobin Alc, and cardiopulmonary function. W further hypothesize that, compared control subjects, individuals randomized to 70% or 80% of baseline energy requirements will not experience adverse change sin thyroid and reproductive hormones, bone mineral density, disease incidence, mood or cognitive function. Dose-response relationships between the extent of CR and changes in outcome variables are anticipated. As part of the study, changes in total energy expenditure and resting metabolic rate, body composition and body temperature will be quantified to document the effects of CR on energy metabolism. We anticipate that the results of this study will have a major impact on our understanding of the relevance of CR to human health. In addition, this study will contribute to the development of new avenues for long- term treatment of overweight and obesity.

降低发病率和延缓死亡率被认为是衰老研究的主要目标，并通过这项为期 2 年的人类热量限制 (CR) 干预提案来解决。一项为期 1 年的试点研究将在 32 名超重男性和女性中进行，以在按基线确定的能量需求的 70% 进食时制定有效的 CR 养生法。作为该试点的一部分，我们将完善 CR 干预的各个方面，包括运动和行为咨询，并将获得有关结果变异性的必要信息，以便为主要研究进行功效计算。受试者将被随机分配到两种具有不同膳食脂肪和血糖指数 (GI) 水平的饮食方案（20% 脂肪和中等 GI 与 35% 脂肪和低 GI），并且将在一年中的 5 个阶段确定饮食依从性和关键结果测量。然后在干预措施的设计中将考虑饮食因素，例如饮食多样性、液体能量来源和膳食纤维。在确定有效的 CR 方案后，将对 117 名超重男性和女性进行为期 2 年的随机干预，喂养量为基线确定的能量需求的 70%、80% 或 100%。将测试该假设，即与喂食 100% 基线能量需求的对照受试者相比。待评估的参数包括免疫功能、氧化应激、空腹胰岛素、血红蛋白Alc和心肺功能。我们进一步假设，与对照受试者相比，随机分配到基线能量需求 70% 或 80% 的个体不会经历甲状腺和生殖激素、骨矿物质密度、疾病发生率、情绪或认知功能的不利变化。 CR 程度与结果变量变化之间的剂量反应关系是预期的。作为研究的一部分，总能量消耗和静息代谢率、身体成分和体温的变化将被量化，以记录 CR 对能量代谢的影响。我们预计这项研究的结果将对我们理解 CR 与人类健康的相关性产生重大影响。此外，这项研究将有助于开发长期治疗超重和肥胖的新途径。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Use of cereal fiber to facilitate adherence to a human caloric restriction program.

DOI：
10.1007/bf03324878
发表时间：
2008-12
期刊：
Aging clinical and experimental research
影响因子：
4
作者：
通讯作者：

Human caloric restriction for retardation of aging: current approaches and preliminary data.

人类热量限制延缓衰老：当前方法和初步数据。

DOI：
10.1093/jn/137.4.1076
发表时间：
2007
期刊：
The Journal of nutrition
影响因子：
0
作者：
Roberts,SusanB;Schoeller,DaleA
通讯作者：
Schoeller,DaleA

Long Term Effects of Energy-Restricted Diets Differing in Glycemic Load on Metabolic Adaptation and Body Composition.

不同血糖负荷的能量限制饮食对代谢适应和身体成分的长期影响。

DOI：
发表时间：
2007
期刊：
The open nutrition journal
影响因子：
0
作者：
Das,SaiKrupa;Gilhooly,CherylH;Golden,JulieK;Pittas,AnastassiosG;Fuss,PaulJ;Dallal,GerardE;McCrory,MeganA;Saltzman,Edward;Roberts,SusanB
通讯作者：
Roberts,SusanB

Low or Moderate Dietary Energy Restriction for Long-term Weight Loss: What Works Best?