Racial and social contextual factors in relation to epigenome and bladder cancer outcome

与表观基因组和膀胱癌结果相关的种族和社会背景因素

• 批准号: 10762048
• 负责人: Laura Solitare
• 金额: $ 3.81万
• 依托单位: TEXAS SOUTHERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762048
• 关键词: Address; African American; African American population; American; Antineoplastic Agents; Behavior; Biological; Biological Factors; Biology; Biomedical Research; Cancer Patient; Cancer Research Project; Carcinogens; Categories; Censuses; Characteristics; Clinical; Collaborations; Communities; Community Developments; Community Health; Comprehensive Cancer Center; Consent; Cross-Sectional Studies; Cystectomy; DNA; DNA Methylation; Data; Data Set; Development; Disadvantaged; Disease Progression; Disparate; Disparity; Drug Kinetics; Economics; Education; Environment; Environmental Risk Factor; Environmental and Occupational Exposure; Epigenetic Process; Ethnic Origin; European; Event; Exhibits; Faculty; Functional disorder; Genes; Geographic Information Systems; Health; Health Services Accessibility; Historically Black Colleges and Universities; Housing; Human; Incidence; Individual; Industry; Inferior; Infrastructure; Institution; Intervention; Interview; Interviewer; Joints; Life Cycle Stages; Link; Location; Malignant Neoplasms; Malignant neoplasm of urinary bladder; Measures; Mediating; Medicine; Methylation; Minority Groups; Modification; Molecular and Cellular Biology; Neighborhoods; Neoplasm Circulating Cells; Neoplasm Metastasis; Occupational; Occupational Exposure; Outcome; Outcome Measure; Pathway interactions; Patients; Persons; Pilot Projects; Plants; Play; Policies; Policy Research; Printing; Prognostic Marker; Public Health; Race; Recording of previous events; Reporting; Research; Resource Sharing; Risk; Role; Rubber; Running; Smoking History; Social Environment; Source; Specimen; Surveys; Testing; Texas; Textiles; Tissue Sample; Tumor Bank; U.S. Department of Housing and Urban Development; Universities; Work; Workplace; Xenobiotics; anticancer research; built environment; cancer health disparity; carcinogenicity; college; community engagement; contextual factors; drug discovery; education research; epigenome; epigenomics; ethnic minority; experience; health care availability; health data; health disparity populations; member; methylation pattern; mortality; neighborhood disadvantage; outreach; programs; racial disparity; racial minority; recruit; social culture; social factors; social health determinants; socioeconomics; software systems; stressor; timeline; tumor; tumor progression

CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU), an institution serving underserved health disparity populations and a historically black college and university (HBCU), to establish the Baylor-Texas Southern P20 consortium or BCM-TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED). BCM-TSU P20 CURED will develop the infrastructure for a cancer research program with a specific focus on cancer health disparities (including biology, outcomes, and access to treatment) and community engagement with a joint Cancer Research Education Program. This collaboration builds upon complementary expertise in cancer health disparities at DLDCCC/BCM and TSU, cancer drug discovery and pharmacokinetics at TSU, and robust patient and community- focused outreach and engagement focused on predominantly minority populations of both institutions with complementary expertise and allowance of shared resources and ongoing joint endeavors with both institutions. The proposal for BCM-TSU P20 CURED includes the Center of Excellence for Housing and Community Development Policy Research (CEHCDPR), a U.S. Department of Housing and Urban Development Center of Excellence, at TSU as a member of the research team. Faculty with CEHCDPR will partner with faculty from the Department of Molecular and Cellular Biology at BCM to study the associations between the social determinants of health (SDOH) and bladder cancer to understand the racial disparities in disease progression, in which African Americans experience more severe outcomes than Whites. CEHCDPR will develop a SDOH interviewer-administered survey that will include questions about socioeconomic characteristic, smoking history, and health care access, and residential and workplace history. BCM will administer the survey to consenting bladder cancer patients. Once BCM has completed the survey, CEHCDPR will use Geographic Information Systems software to geolocate each patient’s historical residential location. CEHCDPR will compile data layers from existing sources, including US Census and US EPA, on the socioeconomic and environmental conditions of the patient’s residential neighborhoods. Concurrently, BCM will run DNA testing of tissue samples from the patients who completed the survey. The CEHCDPR and BCM datasets will be combined and CEHCDPR will analyze the data to evaluate the association between the SDOH and the cancer DNA data.

已治愈的试点项目2总结 这项建议需要加强丹、L和邓肯综合癌症中心之间的努力 贝勒医学院(BCM)和德克萨斯南方大学(TSU) 服务于服务不足的健康差距人群和历史上的黑人学院和大学(HBCU)， 建立贝勒-德克萨斯南部P20联盟或BCM-TSU P20癌症合作联盟 研究、教育和差距(治愈)。BCM-TSU P20 Celered将为 癌症研究计划，特别关注癌症健康差异(包括生物学、结果、 和获得治疗)和社区参与联合癌症研究教育计划。 这一合作建立在DLDCCC/BCM在癌症健康差异方面的互补专业知识基础上 和TSU，TSU的癌症药物发现和药代动力学，以及强大的患者和社区- 将重点放在这两个机构以少数族裔为主的人口上 具有互补的专业知识和共享资源的余地，并正在与 两个机构都是。 BCM-TSU P20 CREED的提案包括住房和社区卓越中心 发展政策研究(CEHCDPR)，美国住房和城市发展中心 作为研究团队的一员，在德克萨斯州立大学获得卓越奖。CEHCDPR的教职员工将与教职员工合作 来自BCM分子和细胞生物学系的研究人员 健康的社会决定因素(SDOH)和膀胱癌，以了解疾病的种族差异 进展，非洲裔美国人经历比白人更严重的后果。CEHCDPR将 开发一份由SDOH面试者管理的调查，其中将包括有关社会经济的问题 特征、吸烟史和医疗保健途径，以及居住和工作场所历史。BCM将 对同意的膀胱癌患者进行调查。一旦BCM完成调查， CEHCDPR将使用地理信息系统软件对每个患者的病史进行地理定位 住宅区。CEHCDPR将从现有来源编译数据层，包括美国人口普查和 美国环保局，关于患者居住社区的社会经济和环境条件。 同时，BCM将对完成调查的患者的组织样本进行DNA测试。 CEHCDPR和BCM数据集将被合并，CEHCDPR将分析数据以评估 SDOH与癌症DNA数据之间的关联。