ADEPT-STAR therapy for high risk neuroblastoma
ADEPT-STAR 治疗高危神经母细胞瘤
基本信息
- 批准号:10760738
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAllogenicAmericanBiodistributionCategoriesCell LineCell TherapyCell modelCellsChemistryChildhoodClassificationClinicalCollectionCommercial SectorsCustomDNA cassetteDataDevelopmentDevelopment PlansDiagnosisDisease remissionDoseEmbryoGene DeliveryGene TransferGenerationsGenesGenotypeGoalsHealthHemophilia AHumanImmunooncologyIn VitroIn complete remissionIndividualInfantKidneyLeadLengthLive BirthMalignant NeoplasmsMarketingMedicalMonoclonal Antibody TherapyMusNeuroblastomaNeuroendocrine TumorsOncologyOutcomePatientsPerformancePharmaceutical PreparationsPharmacologyPhenotypePrevalenceProcessProductionProgram DevelopmentPropertyRecombinantsRed CrossRelapseSurvival RateSystemT-Cell DevelopmentT-LymphocyteTechnologyTestingTherapeuticTissuesTraditional MedicineTumor AntigensValidationXenograft Modelchemotherapyclinical developmentcostcytotoxicitycytotoxicity testdesigndrug developmentexpectationexperienceexpression vectorgene therapyhigh riskhigh risk populationimmuno-gene therapyimprovedin vivoinnovationlead optimizationmanufacturemanufacturing runmeetingsneuroblastoma cellnovel therapeuticspharmacokinetics and pharmacodynamicspharmacologicpre-clinicalpreclinical developmentpreclinical efficacyproduct developmentresponsestandard of caresuccesstechnology platformtherapeutic transgenetransgene expressiontumortumor xenograftvectorγδ T cells
项目摘要
PROJECT SUMMARY
Cancer remains a primary health concern despite significant advancements in treatment. In the past decade, cell
and gene (C&G) therapies along with immuno-oncology (I-O) therapies have transformed treatment expectations
by extending cancer free survival and complete remissions. Despite these remarkable successes, they are limited
to a subset of cancers and many significant challenges remain for broader application and to unlock the perceived
medical and commercial potential. Expression Therapeutics, Inc. (ET) is a fully integrated C&G therapy company
addressing these unmet clinical needs by using proprietary and complementary platform technologies that
optimize therapeutic transgene expression and gene delivery for the development of off-the-shelf allogeneic-
based gene therapies. These technologies address major challenges being encountered in C&G I-O: identification
of safe and effective tumor targets, maximizing treatment durability and efficacy and reducing the cost of goods.
Results of preliminary in vitro and in vivo studies support feasibility of the proposed application and the successful
development of this robust platform for the treatment of pediatric neuroblastomas and other forms of
neuroendocrine tumors (NETs) proposed in this application.
项目摘要
癌症仍然是一个主要的健康问题,尽管在治疗方面取得了重大进展。在过去的十年里,Cell
基因(C & G)疗法与免疫肿瘤学(I-O)疗法一起沿着,
通过延长无癌生存期和完全缓解。尽管取得了这些显著的成就,
癌症的一个子集,许多重大的挑战仍然是更广泛的应用,并解开感知
医疗和商业潜力。Expression Therapeutics,Inc. (ET)是一家完全整合的C & G治疗公司
通过使用专有和互补的平台技术解决这些未满足的临床需求,
优化治疗性转基因表达和基因递送,用于开发现成的同种异体-
基因疗法。这些技术解决了C & G I-O遇到的主要挑战:
安全有效的肿瘤靶点,最大限度地提高治疗持久性和疗效,降低商品成本。
初步的体外和体内研究结果支持拟议应用的可行性,
开发这种用于治疗小儿神经母细胞瘤和其他形式的神经母细胞瘤的强大平台
神经内分泌肿瘤(NET)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher Bradley Doering其他文献
Christopher Bradley Doering的其他文献
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{{ truncateString('Christopher Bradley Doering', 18)}}的其他基金
Immunopharmacology of FVIII Bioengineering and Gene Therapy
FVIII 生物工程和基因治疗的免疫药理学
- 批准号:
10406904 - 财政年份:2018
- 资助金额:
$ 40万 - 项目类别:
Bone Marrow-Derived Stem Cell Therapy of Hemophilia A
甲型血友病的骨髓干细胞疗法
- 批准号:
7194510 - 财政年份:2007
- 资助金额:
$ 40万 - 项目类别:
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