Mentorship in patient-oriented research to optimize community-based HIV prevention for adults at high-risk of HIV at alcohol drinking venues in East Africa

指导以患者为导向的研究，以优化东非饮酒场所艾滋病毒高危成年人的社区艾滋病毒预防

• 批准号: 10762303
• 负责人: Gabriel Chamie
• 金额: $ 19.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762303
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Adult; Africa; Africa South of the Sahara; African; Alcohol abuse; Alcohol consumption; Alcohols; Attention; Award; Awareness; California; Caring; Clinic; Clinical Trials; Collaborations; Communicable Diseases; Communities; Community Trial; Consumption; Counseling; Country; Educational workshop; Effectiveness; Facility Accesses; Faculty; Future; Goals; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; HIV/TB; Health Personnel; Health care facility; Hot Spot; Human immunodeficiency virus test; Incidence; Infrastructure; Intervention; Interview; Kenya; Measures; Medical; Medical Research; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Perception; Persons; Physicians; Play; Population; Prevalence; Prevention; Prevention Research; Prevention approach; Prophylactic treatment; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Institute; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Rural; San Francisco; Services; Site; Surveys; Time; Training; Transact; Uganda; Universities; Unsafe Sex; Viral; Work; alcohol misuse; arm; career; career development; community intervention; community setting; cost; drinking; experience; female sex worker; health care availability; high risk; human centered design; implementation framework; implementation outcomes; improved; innovation; interest; intervention delivery; member; mid-career faculty; novel; outreach; patient oriented; patient oriented research; person centered; pilot test; pilot trial; postdoctoral investigator; pre-doctoral; pre-exposure prophylaxis; preference; prevention effectiveness; prevention service; preventive intervention; primary outcome; programs; prototype; recruit; service delivery; sex; social stigma; testing services; therapy development; transmission process; treatment services; uptake

Project Summary Dr. Gabriel Chamie is an infectious diseases physician and Associate Professor of Medicine in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco (UCSF). His research has focused on developing effective approaches to promote community-based diagnosis of HIV, TB and SARS-CoV-2, and engagement in HIV and TB prevention and treatment, with a more recent focus on persons with unhealthy alcohol use in East Africa. He has over a decade of experience mentoring numerous early-stage investigators (ESI), including pre- and post-doctoral investigators and junior faculty, and now seeks the protected time of a K24 award to focus greater attention and time on mentoring, mentorship training and expanding his research program at the intersection of HIV and alcohol use. In this application, Dr. Chamie proposes a comprehensive mentorship, mid-career development, and research plan to address the challenge of reaching and engaging populations at increased risk of HIV in biomedical HIV prevention from alcohol drinking venues in East Africa. Despite a growing number of efficacious biomedical HIV prevention options, a major challenge remains reaching persons at highest risk of HIV – such as adults at alcohol drinking venues – who do not routinely engage in medical care, to overcome barriers to HIV prevention initiation and retention, including alcohol use. To further develop and expand his patient-oriented research (POR) program and mentoring, he proposes mid-career training in methods that support the application of quantitative preference elicitation and human-centered design for intervention development, and additional training in mentorship. Leveraging the infrastructure of his recently awarded R01 (the OPAL trial) and the ongoing SEARCH- SAPPHIRE trial, Dr. Chamie proposes research in this application to: a) elicit preferences for biomedical HIV prevention service delivery among adults at high risk of HIV who attend drinking venues in rural Kenya and Uganda, b) to adapt the SAPPHIRE trial’s clinic-based “dynamic PrEP/PEP choice” intervention for community- based delivery to this population at or near drinking venues, and c) to assess uptake, retention, and adherence to biomedical prevention in a pilot trial of community-based biomedical prevention delivery among adults who attend or work at drinking venues in rural Kenya and Uganda. With the guidance of an experienced senior mentorship team, Dr. Chamie will utilize multiple ongoing research projects, and long-standing research collaborations between UCSF and Makerere University in Uganda and the Kenya Medical Research Institute in Kenya, to provide mentees with a robust infrastructure on which to develop their research interests and support US-East African ESI partnerships in POR. The K24 award is instrumental to supporting him in achieving his long-term goals of becoming a global leader in HIV and alcohol use research and mentoring future leaders in patient-oriented research from the US and East Africa.

项目摘要 博士Gabriel Chamie是一名传染病医生，也是美国医学部的医学副教授。 艾滋病毒，传染病和全球医学在加州大学，旧金山弗朗西斯科（UCSF）。他 研究的重点是开发有效的方法，以促进以社区为基础的艾滋病毒，结核病， 和SARS-CoV-2，以及参与艾滋病毒和结核病的预防和治疗，最近的重点是 东非不健康饮酒的人。他有十多年的指导经验， 早期研究人员（ESI），包括博士前和博士后研究人员和初级教师，现在寻求 K24奖励的受保护时间，以将更多的注意力和时间集中在指导，指导培训和 在艾滋病和酒精使用的交叉点上扩展他的研究计划。在本申请中，Chamie博士 提出了一个全面的指导，中期职业发展和研究计划，以应对挑战 接触艾滋病毒风险增加的人群并使其参与预防酒精引起的艾滋病毒的生物医学工作 在东非喝酒的地方尽管有越来越多的有效的生物医学艾滋病毒预防方案， 主要的挑战仍然是接触艾滋病毒风险最高的人-例如在饮酒场所的成年人- 那些不经常从事医疗保健的人，克服艾滋病毒预防启动和保留的障碍， 包括酒精的使用。为了进一步发展和扩大他的以病人为导向的研究（POR）计划， 指导，他建议职业中期培训的方法，支持定量偏好的应用 启发式和以人为本的干预开发设计，以及辅导方面的额外培训。 利用他最近获得的R 01（OPAL试验）的基础设施和正在进行的研究， SAPPHIRE试验，Chamie博士提出在此应用程序中的研究：a）引起对生物医学HIV的偏好 在肯尼亚农村地区的饮酒场所为艾滋病毒高危成年人提供预防服务， 乌干达，B）将SAPPHIRE试验的基于诊所的“动态PrEP/PEP选择”干预措施适用于社区- 基于在饮用场所或附近向该人群的递送，以及c）评估摄取、保留和依从性 在一项以社区为基础的生物医学预防服务试点试验中， 前往肯尼亚和乌干达农村的饮酒场所或在那里工作。在一位经验丰富的前辈的指导下 Chamie博士的导师团队将利用多个正在进行的研究项目和长期研究 加州大学旧金山分校与乌干达马凯雷雷大学和肯尼亚医学研究所之间的合作， 肯尼亚，为学员提供强大的基础设施，以发展他们的研究兴趣和支持 美国-东非能源机构在POR的伙伴关系。K24奖有助于支持他实现自己的目标。 长期目标是成为艾滋病毒和酒精使用研究的全球领导者，并指导未来的领导者， 来自美国和东非的以病人为导向的研究。