Administrative Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)

行政核心 - 西北大学艾滋病毒/艾滋病和新发传染病即时护理技术创新中心 (C-THAN)

• 批准号: 10762199
• 负责人: Chad J Achenbach
• 金额: $ 37.5万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-11 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762199
• 关键词: Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Africa; Ally; Award; Biomedical Engineering; Caring; Chad; Charge; Clinical; Clinical Research; Collaborations; Communicable Diseases; Communication; Complex; Decision Making; Development; Devices; Diagnostic; Doctor of Philosophy; Emergency Situation; Emerging Communicable Diseases; Engineering; Funding; Goals; Grant; HIV; HIV/AIDS; HIV/TB; Health; Home; Individual; Institution; Lateral; Lead; Leadership; Mali; Medical; Medical Device; Medicine; Mission; Modeling; Molecular; National Institute of Biomedical Imaging and Bioengineering; Nigeria; Office of Administrative Management; Persons; Physicians; Point of Care Technology; Process; Public Health; Recording of previous events; Research; Research Design; Research Personnel; Research Training; Science; Senegal; Site; South Africa; Structure; Tanzania; Techniques; Technology; United States; United States National Institutes of Health; Universities; commercialization; conflict resolution; diagnostic technologies; experience; improved; infrastructure development; innovation; low and middle-income countries; multidisciplinary; next generation; point of care; programs; synthetic biology; technology platform; technology research and development; working group

SUMMARY – ADMINISTRATIVE (ADMIN) CORE The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern (C-THAN) will be a vital partner as a Technology Research and Development Centers (TRDC) in the NIBIB Point-of-Care Technologies Research Network (POCTRN) focusing its mission to catalyze innovation in diagnostic technologies through a model that enhances complementary strengths to build multidisciplinary partnerships across technology platforms, clinical, regulatory and commercialization domains with a specific focus on HIV/AIDS and emerging infectious diseases in low- and middle-income countries (LMICs). The structure of C-THAN will consist of scientific and technology expertise in point-of-care (POC) and home-based diagnostics along with clinical study design and sites to facilitate the identification and integration of enabling technologies into devices that address the specific clinical needs of HIV/AIDS and emerging infectious diseases. C-THAN will be comprised of four Cores: Administrative, Technology, Clinical, and Dissemination. An emphasis will be directed to specific technology domains by establishing the following technology working groups (WG): 1) molecular, 2) lateral flow, 3) synthetic biology, and 4) product engineering. The Admin Core will provide the appropriate leadership and structure to manage the many facets of C-THAN, a large and complex TRDC. The Admin Core will serve as the managing component of C-THAN that is charged with leading the organization, governance of the center, collaboration within and outside POCTRN, communication and continuous quality improvement and efficiency of the activities. C-THAN will be directed by the MPIs, Drs. Chad Achenbach, MD, MPH, a biomedical engineer (BME) and medical doctor with expertise in infectious diseases and public health with over 20 years of experience in clinical research on HIV and emerging infectious diseases, Robert Murphy, MD, an infectious diseases trained research physician who has been working in Africa for more than 22 years, Sally McFall, PhD a biomedical engineer and expert in developing POC medical devices for Africa. They will be assisted by the C-THAN Steering Committee which will provide scientific and administrative oversight of C-THAN functions including review and selection of projects to receive sub-award funding. Key partner institutions of C-THAN include Northwestern University (lead partner); University of Cape Town, University of the Witwatersrand (WITS), Stellenbosch University, University of Lagos, University of Ibadan, University of Jos, Muhimbili University of Health and Allied Sciences (MUHAS), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), and the University Cheikh Anta Diop (UCAD). The C-THAN consortium will build upon its 20-year history of infrastructure development and research training with key partners in Nigeria, Mali, Senegal, Tanzania, and South Africa.

摘要-行政（管理）核心 艾滋病毒/艾滋病和新兴传染病护理点技术创新中心 西北疾病（C-THAN）将成为技术研发的重要合作伙伴 NIBIB护理点技术研究网络（POCTRN）的中心（TRDC），其使命集中在 通过增强互补优势的模式促进诊断技术的创新， 在技术平台、临床、监管和商业化方面建立多学科合作伙伴关系 特别侧重于中低收入国家艾滋病毒/艾滋病和新出现的传染病 中低收入国家。C-THAN的结构将包括护理点的科学和技术专业知识 (POC)和基于家庭的诊断沿着临床研究设计和研究中心，以便于识别和 将使能技术整合到满足艾滋病毒/艾滋病特定临床需求的设备中， 新出现的传染病C-THAN将由四个核心组成：行政，技术，临床， 和传播。重点将通过建立以下内容来针对特定的技术领域 技术工作组（WG）：1）分子，2）侧流，3）合成生物学，4）产品工程。 管理核心将提供适当的领导和结构来管理C-THAN的各个方面， 一个庞大而复杂的TRDC管理核心将作为C-THAN的管理组件， 负责领导组织、中心治理、POCTRN内外协作， 沟通和持续的质量改进和活动的效率。C-THAN将被引导 Chad Achenbach博士，医学博士，公共卫生硕士，生物医学工程师（BME）和医学博士， 在传染病和公共卫生领域拥有20多年的艾滋病毒临床研究经验， 罗伯特·墨菲，医学博士，一位受过传染病训练的研究医生， Sally McFall博士是一位生物医学工程师，也是非洲的专家，她在非洲工作了22年多。 为非洲开发POC医疗设备。他们将得到C-THAN指导委员会的协助， 将对C-THAN功能进行科学和行政监督，包括审查和选择 项目获得次级奖资助。C-THAN的主要合作机构包括西北大学 (lead合作伙伴）;开普敦大学、威特沃特斯兰德大学、斯泰伦博斯大学、 拉各斯大学、伊巴丹大学、乔斯大学、Muhimbili卫生和相关科学大学 （MUHAS）、巴马科科学、技术和工艺大学（USTB）和 安塔迪奥普大学（UCAD）。C-THAN联盟将在其20年的历史基础上， 与尼日利亚、马里、塞内加尔、坦桑尼亚的主要合作伙伴开展基础设施开发和研究培训， 南非