Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules

不确定肝结节患者的精准风险分层和 HCC 筛查

基本信息

  • 批准号:
    10736885
  • 负责人:
  • 金额:
    $ 90.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-19 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Large gaps in current strategies for risk stratification and surveillance contribute to frequent late-stage detection and poor outcomes in patients with hepatocellular carcinoma (HCC). Our Translational Liver Cancer (TLC) Research Center has made important scientific contributions that directly addressed HCC risk stratification and surveillance in patients with cirrhosis. Specifically, we conducted a series of phase II and phase III biomarker studies in patients with cirrhosis to validate 1) the first blood-based biomarker for risk stratification (PLSec-AFP), 2) abbreviated MRI for HCC surveillance, and 3) two biomarker panels, GALAD and Doylestown Plus for HCC surveillance. We also conducted modeling studies to evaluate how these data can be incorporated into clinical practice, evaluating the cost-effectiveness of a precision surveillance strategy in these patients. For our TLC renewal, we leverage our infrastructure and operational expertise to similarly develop an optimized, evidence-based approach to early HCC detection in patients with indeterminate liver nodules (ILNs). Our preliminary data demonstrate that patients with ILNs have an annual HCC risk of 6-10%/year, more than double that of those with cirrhosis without ILNs; however, they experience wide variation in HCC risk and surveillance strategies – with some patients who develop HCC failing to undergo surveillance in the year prior to diagnosis and some patients undergoing repeated CT/MRI-based surveillance despite never developing HCC. Our work highlights the need for accurate risk stratification and surveillance strategies in patients with ILNs to optimize the overall value of early HCC detection programs – gaps that are directly addressed by our proposal. We will leverage our Early Detection Research Network (EDRN)-funded Clinical Validation Center for HCC to efficiently recruit a large cohort of patients with ILNs and (1) validate the effectiveness of a novel biomarker- based risk stratification model, (2) evaluate the effectiveness of surveillance abbreviated MRI and contrast enhanced ultrasound for detecting early-stage HCC, and (3) compare the cost effectiveness of surveillance strategies including a precision screening model in patients with ILNs. Our proposal aligns with the principles of precision medicine and would maximize benefits (via early tumor detection) and minimize harms (via false positive results) for each patient, thereby optimizing the patient- centeredness, cost effectiveness, and overall value of HCC surveillance in patients with ILNs. In addition to our patient cohorts and platform of unique biomarker and imaging data, our TLC research center will contribute methodological expertise in HCC early detection, biomarker validation, and HCC imaging to trans-network projects. Overall, our proposal will transform our approach to early HCC detection in patients with ILNs by validating evidence-based and cost-effective strategies to optimize HCC risk stratification and surveillance.
项目摘要 目前的风险分层和监测策略存在很大差距,这导致了频繁的晚期检测 肝细胞癌(HCC)患者的预后较差。我们的转化型肝癌(TLC) 研究中心做出了重要的科学贡献,直接解决了HCC风险分层, 肝硬化患者的监测。具体来说,我们进行了一系列II期和III期生物标志物 在肝硬化患者中进行的研究,以验证1)用于风险分层的第一个基于血液的生物标志物(PLSec-AFP), 2)用于HCC监测的简化MRI,以及3)用于HCC的两种生物标志物组,GALAD和多尔斯敦Plus 监视我们还进行了建模研究,以评估如何将这些数据纳入临床 实践,评估这些患者的精确监测策略的成本效益。 对于我们的TLC更新,我们利用我们的基础设施和运营专业知识, 不确定性肝结节(ILN)患者早期HCC检测的循证方法。我们 初步数据表明,ILN患者的年HCC风险为6-10%/年,是ILN患者的两倍多。 肝硬化而无ILN的患者;然而,他们在HCC风险和监测方面存在很大差异, 策略-一些患有HCC的患者在诊断前一年未接受监测 还有一些患者尽管从未发生HCC,但仍反复接受基于CT/MRI的监测。我们的工作 强调了对ILN患者进行准确的风险分层和监测策略的必要性, 早期HCC检测计划的总体价值-我们的提案直接解决了这些差距。 我们将利用我们的早期检测研究网络(EDRN)资助的HCC临床验证中心, 有效招募大量ILN患者,以及(1)验证新生物标志物的有效性, 基于危险分层模型,(2)评价简化MRI和对比剂监测的有效性 增强超声检测早期肝癌,(3)比较监测的成本效益 包括对ILN患者的精确筛查模型。 我们的建议符合精准医学的原则,并将最大限度地提高效益(通过早期肿瘤 检测),并最大限度地减少伤害(通过假阳性结果),为每个病人,从而优化病人- ILN患者HCC监测的中心性、成本效益和总体价值。除了我们 患者队列和独特的生物标志物和成像数据的平台,我们的TLC研究中心将有助于 HCC早期检测、生物标志物验证和HCC成像方面的方法学专业知识, 项目总的来说,我们的建议将通过以下方式改变我们对ILN患者早期HCC检测的方法: 验证基于证据和成本效益的策略,以优化HCC风险分层和监测。

项目成果

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Yujin Hoshida其他文献

Yujin Hoshida的其他文献

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{{ truncateString('Yujin Hoshida', 18)}}的其他基金

Epigallocatechin gallate for prevention of lethal cirrhosis complications
表没食子儿茶素没食子酸酯用于预防致命性肝硬化并发症
  • 批准号:
    10713745
  • 财政年份:
    2023
  • 资助金额:
    $ 90.72万
  • 项目类别:
Reverse-engineering precision liver cancer chemoprevention
逆向工程精准肝癌化学预防
  • 批准号:
    10698060
  • 财政年份:
    2019
  • 资助金额:
    $ 90.72万
  • 项目类别:
Reverse-engineering precision liver cancer chemoprevention
逆向工程精准肝癌化学预防
  • 批准号:
    10021620
  • 财政年份:
    2019
  • 资助金额:
    $ 90.72万
  • 项目类别:
Non-invasive monitoring of metabolic liver cancer risk
无创监测代谢性肝癌风险
  • 批准号:
    10515278
  • 财政年份:
    2019
  • 资助金额:
    $ 90.72万
  • 项目类别:
Reverse-engineering precision liver cancer chemoprevention
逆向工程精准肝癌化学预防
  • 批准号:
    10916614
  • 财政年份:
    2019
  • 资助金额:
    $ 90.72万
  • 项目类别:
Reverse-engineering precision liver cancer chemoprevention
逆向工程精准肝癌化学预防
  • 批准号:
    10228002
  • 财政年份:
    2019
  • 资助金额:
    $ 90.72万
  • 项目类别:
Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
肝硬化和癌症的分子预后指标
  • 批准号:
    8559992
  • 财政年份:
    2013
  • 资助金额:
    $ 90.72万
  • 项目类别:
Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
肝硬化和癌症的分子预后指标
  • 批准号:
    9135412
  • 财政年份:
    2013
  • 资助金额:
    $ 90.72万
  • 项目类别:
Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
肝硬化和癌症的分子预后指标
  • 批准号:
    8889974
  • 财政年份:
    2013
  • 资助金额:
    $ 90.72万
  • 项目类别:
Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
肝硬化和癌症的分子预后指标
  • 批准号:
    8698413
  • 财政年份:
    2013
  • 资助金额:
    $ 90.72万
  • 项目类别:

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