Novell hybrid mass spectrometer

Novell 混合质谱仪

• 批准号: 7480858
• 负责人: Alexander Misharin
• 金额: $ 10万
• 依托单位: SCIENCE AND ENGINEERING SERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-05 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480858
• 关键词: Area; Attention; Biological; Biological Sciences; Body Fluids; Cell Cycle Progression; Cell physiology; Cells; Communities; Compatible; Condition; Cyclotrons; Detection; Devices; Dissociation; Electrons; Engineering; Event; Face; Frequencies; Gases; Genes; Government; Hand; Human; Human body; Hybrids; Image; Information Sciences; Ions; Label; Left; Lipids; Maps; Marketing; Mass Spectrum Analysis; Medical; Medical Research; Methods; Modification; Monitor; Nature; Pathway interactions; Pattern; Peptides; Performance; Persons; Phosphorylation; Physiological; Play; Post-Translational Protein Processing; Price; Process; Proteins; Proteome; Proteomics; Purpose; Radio; Range; Reaction; Resolution; Role; Scanning; Serine; Services; Signal Transduction; Standards of Weights and Measures; Structure; Techniques; Technology; Thinking; Threonine; Time; Tyrosine; Vacuum; Variant; analytical tool; base; cost; instrument; mass analyzer; mass spectrometer; novel; pressure; protein expression; stoichiometry; success; tandem mass spectrometry; time interval; tool; ultra high resolution

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel hybrid mass spectrometer with unique mass selection and fragmentation capabilities. Implementation of this instrument will advance methods of quantitation using isotopically labeled standards, multiple precursor ion scanning multiple reaction monitoring and hypotheses-driven approaches in proteomics, lipidomics and other life-science areas. Implementation of the technology could potentially result in significant improvement of the dynamic range of protein identification and quantitation and make 105 - 106 dynamic ranges readily achievable.

描述（由申请人提供）：本提案的目的是开发一种具有独特质量选择和裂解能力的新型混合质谱仪。该仪器的实施将推进定量方法，使用同位素标记的标准，多前体离子扫描多反应监测和假设驱动的方法在蛋白质组学，脂质组学和其他生命科学领域。该技术的实施可能会导致蛋白质鉴定和定量的动态范围的显著改善，并使105 - 106的动态范围容易实现。