The Development of a Web-based Data Retrieval System for HIV Therapy Guidance

描述（由申请人提供）：在世界上受艾滋病毒流行影响最严重的地区，卫生保健经济学无法支持复杂的诊断测试，如耐药性表型。因此，迫切需要开发生物信息学解决方案，使药物活性和治疗结果的预测能够基于临床数据和结果不那么复杂和更广泛的测试程序，如基因分型。拟议的第二阶段努力项目的最终目标是开发一个网络支持的数据库检索系统，该系统将作为基于订阅的产品商业化的基础，支持艾滋病毒/艾滋病患者的临床管理和新疗法的开发。拟议研究的成功完成将导致开发一个广泛可访问的基于网络的工具，该工具将为临床医生和研究人员提供广泛访问艾滋病毒数据综合仓库的途径。预期获得这些数据将有助于用户进行艾滋病毒/艾滋病的临床管理和开发新的有效疗法和治疗方案。拟议的艾滋病毒信息检索系统将访问Monogram的艾滋病毒耐药性数据库，该数据库是在I期工作期间开发的，目前包含超过76,000例患者病毒的匹配表型和基因型耐药性数据。在成功完成II期工作后，用户将能够获得宝贵的耐药性信息，用于患者护理和药物发现研究。根据拟议的第二阶段努力，将处理三个具体目标。在目标1中，我们将开发、测试和实现一个商业上可用的网络支持的数据库查询工具，该工具具有通过基因型突变和/或表型易感性模式搜索数据库的能力。在目标2中，我们将开发一个基于订阅的治疗指导网络工具。在目标3中，我们将开发、实施和测试数据库存储和互联网访问安全性。成功完成这三个具体目标将使基于网络的新型产品能够商业化，这些产品将有可能在世界范围内推进和改善艾滋病毒/艾滋病的治疗。拟议的第二阶段努力项目的最终目标是开发一个网络支持的数据库检索系统，该系统将作为基于订阅的产品商业化的基础，支持艾滋病毒/艾滋病患者的临床管理和新疗法的开发。拟议研究的成功完成将导致开发一个广泛可访问的基于网络的工具，该工具将为临床医生和研究人员提供广泛访问艾滋病毒数据综合仓库的途径。

DESCRIPTION (provided by applicant): In areas of the world most negatively impacted by the HIV epidemic, healthcare economics are unable to support complex diagnostic testing such as drug resistance phenotyping. Consequently, there is a pressing need to develop bioinformatic solutions that will enable predictions of drug activity and treatment outcome based on clinical data and the results less complex and more broadly available test procedures such as genotyping. The ultimate goal of the proposed phase II effort project is the development of a web-supported database retrieval system that will serve as the foundation for the commercialization of subscription-based products that support the clinical management of HIV/AIDS patients and the development of novel therapeutics. The successful completion of the proposed study will result in the development of a broadly accessible web based tool that will provide clinicians and researchers with broad access to a comprehensive warehouse of HIV data. Access to these data is expected to assist users in the clinical management of HIV/AIDS and the development of novel and effective therapeutics and treatment regimens. The proposed HIV information retrieval system will access Monogram's HIV resistance database that was developed during the phase I effort and currently contains matching phenotypic and genotypic resistance data on more that 76,000 patient viruses. Upon the successful completion of the phase II effort, users will have access to valuable resistance information for patient care and drug discovery research. Under the proposed phase II effort, three specific aims will be addressed. In aim 1, we will develop, test, and implement a commercially available web- supported database query tool with the ability to search the database by genotypic mutation and/or phenotypic susceptibility patterns. In aim 2, we will develop a subscription-based web tool for therapy guidance. In aim 3, we will develop, implement and test database storage and internet-access security. Successful completion of these three specific aims will enable the commercialization of novel web-based products that will have the potential to advance and improve the treatment of HIV/AIDS worldwide. The ultimate goal of the proposed phase II effort project is the development of a web- supported database retrieval system that will serve as the foundation for the commercialization of subscription-based products that support the clinical management of HIV/AIDS patients and the development of novel therapeutics. The successful completion of the proposed study will result in the development of a broadly accessible web based tool that will provide clinicians and researchers with broad access to a comprehensive warehouse of HIV data.