Enhancing Vivarium Efficiency and Safety at South Dakota State University with a Modernized Pass-Through Autoclave

使用现代化的直通式高压灭菌器提高南达科他州立大学动物饲养场的效率和安全性

• 批准号: 10737439
• 负责人: Michele Rene Mucciante
• 金额: $ 25.81万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10737439
• 关键词: 20 year old; Affect; Animal Experimentation; Animal Welfare; Animals; Award; Biological; Biology; Biomedical Research; Centers of Research Excellence; Charge; Chemistry; Communities; Contracts; Dedications; Discipline; Equipment; Failure; Funding; Gnotobiotic; Industry Standard; Infectious Diseases Research; Infrastructure; Investments; Laboratory Animal Production and Facilities; Lead; Maintenance; Modeling; Modernization; Personal Satisfaction; Pharmacy facility; Phase; Positioning Attribute; Procedures; Process; Reporter; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Risk; Safety; Savings; Scheme; Science; Services; South Dakota; Sterilization; Training; United States National Institutes of Health; Universities; Vendor; Veterinarians; Veterinary Medicine; Work; animal breeding; animal care; biosecurity; cost; end of life; energy efficiency; improved; occupational health/safety; operation; programs; service providers; square foot; surgical service

Project Summary/Abstract The shared-use animal research facility (vivarium) at South Dakota State University (SDSU) aims to improve occupational health and safety of staff and support growing the capacity and variety of biomedical research with the installation of a modern, large capacity pass-through autoclave. The current small, single-door model autoclave is near end-of-life with 20+ years of service and increased maintenance costs. This increased risk of failure or extended downtime due to maintenance could jeopardize research projects, including those supported by a $10.8 million NIH COBRE Phase 1 award. The SDSU vivarium supports research across multiple disciplines from biology, chemistry, and pharmacy to veterinary medicine and animal science. Among those supported by NIH, SDSU investigators currently lead 10 projects with $5.3+ million in active awards (NIH RePORTER, accessed Nov. 4, 2022). More than half of this funding supports investigators who currently use the vivarium for their research. The vivarium’s modernization effort is driven by not only the needs of NIH-funded investigators’ but of the overall needs of investigators using the shared-use facility. The university has responded with investing in and prioritizing infrastructure for biomedical research needs. Specifically, the 33,495-square foot facility supports BSL1, BSL2, BSL 2+ (BSL = Biological Safety Levels) and gnotobiotic animal research programs for the university and surrounding research community. The university veterinarian, the vivarium manager, and technicians work directly with researchers in daily and on-going research support needs. Services include a range of options from basic animal care and breeding colony management to complete gnotobiotic and surgical services. The university’s strategic priority of improving research infrastructure guides the modernization of the facility in recent years and has required a high level of oversight and management by the university veterinarian and vivarium staff. In modernizing the autoclave, a core piece of equipment, the vivarium will increase efficiencies in biosecurity, animal welfare and compliance, staff labor and support services, equipment operations and maintenance. This will provide researchers more comprehensive use of the vivarium, opportunity for expanding their projects, and increased capacity to support the university’s growing biomedical research.

项目摘要/摘要 南达科他州立大学共用动物研究机构（Vivarium） （SDSU）旨在改善员工的占领健康和安全，并支持发展 现代，大型的生物医学研究的能力和种类 容量通过高压灭菌器。当前的小型单门型号高压釜接近 寿命终止，服务超过20年，维护成本增加。这增加了 由于维护而导致的失败风险或延长停机时间可能会危害研究 项目，包括获得1,080万美元的NIH Cobre 1阶段奖项的项目。 SDSU Vivarium支持生物学多个学科的研究， 化学和兽医和动物科学的药房。其中 在NIH的支持下，SDSU调查人员目前领导10个项目，其中53万美元以上 主动奖（NIH记者，访问于2022年11月4日）。这笔资金的一半以上 支持目前使用Vivarium进行研究的调查人员。小体 现代化努力不仅是由NIH资助的调查员的需求驱动的 使用共享使用设施的调查人员的总体需求。大学有 以对生物医学研究需求的基础设施进行投资和优先级的回应。 具体而言，33,495平方英尺的设施支持BSL1，BSL2，BSL 2+（BSL = 生物安全水平）和大学的gnotobiotic动物研究计划 和周围的研究社区。大学兽医，Vivarium 经理，技术人员直接与研究人员进行日常研究和正在进行的研究 支持需求。服务包括基本动物护理和育种的一系列选择 殖民地管理以完成gnotobiotic和手术服务。大学的 改善研究基础设施的战略优先事项指导了现代化 近年来，设施需要高水平的监督和管理 大学兽医和Vivarium工作人员。 在现代化高压灭菌器时，核心设备将增加 生物安全，动物福利和合规性，员工劳动和支持的效率 服务，设备操作和维护。这将为研究人员提供更多 全面使用Vivarium，扩大项目的机会，以及 增加了支持大学不断增长的生物医学研究的能力。