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Role of methylation-dependent pathways in aging and stress

Role of methylation-dependent pathways in aging and stress
甲基化依赖性途径在衰老和压力中的作用
批准号：
10737022
负责人：
Amy Karol Walker
金额：
$63.05万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
未结题
起止时间：
2017-09-01 至 2028-05-31
来源：
https://reporter.nih.gov/project-details/10737022
关键词：
AdultAffectAgingAmino AcidsAnimalsAutomobile DrivingBiologicalBiological ProcessBiologyCaenorhabditis elegansCarbonCell NucleusCellsChromatinCollaborationsDNA MethylationDataDevelopmentDiseaseEngineeringEnvironmentEnzymesEventFamilyGene ExpressionGene Expression ProfileGenesGenetic TranscriptionHeat Stress DisordersHeat-Shock ResponseIndividualIntestinesLabelLinkLiverLongevityMammalsMasksMetabolicMetabolic PathwayMetabolismMethionineMethylationMethyltransferaseModelingMolecularMutationNeuronsNucleotidesPathway interactionsPhenotypePhospholipidsPhysiologicalPolyaminesProcessProductionProtein IsoformsProteinsProteomeProteomicsRNA InterferenceRNA methylationRibosomesRoleS-AdenosylhomocysteineS-AdenosylmethionineSignaling MoleculeSiteSourceSpecificityStressSubcutaneous TissueSystemTestingTherapeutic InterventionTimeTissuesVitamin B 12Vitamin B6biological adaptation to stresschromatin modificationdietaryepigenetic regulationexperimental studygenome-widegenomic locushistone methylationinsightknock-downmagnetic beadsnovelpromoterprotein protein interactionresponsetranscriptome sequencing

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英文摘要
Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.
期刊论文(1)
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会议论文
Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0.
DOI： 10.1093/genetics/iyac085
发表时间： 2022-07-30
期刊： GENETICS
影响因子： 3.3
作者： [Higgins, Daniel P., Weisman, Caroline M., Lui, Dominique S., D'Agostino, Frank A., Walker, Amy K.]
通讯作者： Walker, Amy K.
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans - Supplement
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans
Dual transcriptional programs coordinate lipogenic and membrane stress responsive programs in C. elegans
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