Role of methylation-dependent pathways in aging and stress

甲基化依赖性途径在衰老和压力中的作用

• 批准号: 10737022
• 负责人: Amy Karol Walker
• 金额: $ 63.05万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737022
• 关键词: Adult; Affect; Aging; Amino Acids; Animals; Automobile Driving; Biological; Biological Process; Biology; Caenorhabditis elegans; Carbon; Cell Nucleus; Cells; Chromatin; Collaborations; DNA Methylation; Data; Development; Disease; Engineering; Environment; Enzymes; Event; Family; Gene Expression; Gene Expression Profile; Genes; Genetic Transcription; Heat Stress Disorders; Heat-Shock Response; Individual; Intestines; Label; Link; Liver; Longevity; Mammals; Masks; Metabolic; Metabolic Pathway; Metabolism; Methionine; Methylation; Methyltransferase; Modeling; Molecular; Mutation; Neurons; Nucleotides; Pathway interactions; Phenotype; Phospholipids; Physiological; Polyamines; Process; Production; Protein Isoforms; Proteins; Proteome; Proteomics; RNA Interference; RNA methylation; Ribosomes; Role; S-Adenosylhomocysteine; S-Adenosylmethionine; Signaling Molecule; Site; Source; Specificity; Stress; Subcutaneous Tissue; System; Testing; Therapeutic Intervention; Time; Tissues; Vitamin B 12; Vitamin B6; biological adaptation to stress; chromatin modification; dietary; epigenetic regulation; experimental study; genome-wide; genomic locus; histone methylation; insight; knock-down; magnetic beads; novel; promoter; protein protein interaction; response; transcriptome sequencing

Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.

代谢循环为细胞提供了构建模块和能量货币，但也提供了信号

项目成果

Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0.

• DOI: 10.1093/genetics/iyac085
• 发表时间: 2022-07-30
• 期刊: GENETICS
• 影响因子: 3.3
• 作者: Higgins, Daniel P.;Weisman, Caroline M.;Lui, Dominique S.;D'Agostino, Frank A.;Walker, Amy K.
• 通讯作者: Walker, Amy K.