Role of methylation-dependent pathways in aging and stress

甲基化依赖性途径在衰老和压力中的作用

基本信息

批准号：
10737022
负责人：
Amy Karol Walker
金额：
$ 63.05万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10737022
关键词：
Adult Affect Aging Amino Acids Animals Automobile Driving Biological Biological Process Biology Caenorhabditis elegans Carbon Cell Nucleus Cells Chromatin Collaborations DNA Methylation Data Development Disease Engineering Environment Enzymes Event Family Gene Expression Gene Expression Profile Genes Genetic Transcription Heat Stress Disorders Heat-Shock Response Individual Intestines Label Link Liver Longevity Mammals Masks Metabolic Metabolic Pathway Metabolism Methionine Methylation Methyltransferase Modeling Molecular Mutation Neurons Nucleotides Pathway interactions Phenotype Phospholipids Physiological Polyamines Process Production Protein Isoforms Proteins Proteome Proteomics RNA Interference RNA methylation Ribosomes Role S-Adenosylhomocysteine S-Adenosylmethionine Signaling Molecule Site Source Specificity Stress Subcutaneous Tissue System Testing Therapeutic Intervention Time Tissues Vitamin B 12 Vitamin B6 biological adaptation to stress chromatin modification dietary epigenetic regulation experimental study genome-wide genomic locus histone methylation insight knock-down magnetic beads novel promoter protein protein interaction response transcriptome sequencing

项目摘要

Metabolic cycles provide building blocks and energy currency for the cell, but also signaling molecules that regulate diverse physiological responses from differentiation to aging. The metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene expression in the stress response, a key part of the aging process. We have discovered that individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms regulating local production of SAM will produce novel insights into stress-responses and aging.

代谢周期为电池提供基础和能源货币，但也发出信号从分化到衰老的不同生理反应的分子。这代谢产物S-腺苷甲硫氨酸（SAM）就是一种用于调节基因的因素在压力反应中的表达，这是衰老过程的关键部分。我们发现单个SAM合酶具有明显的作用，并假设发现机制调节SAM的本地生产将产生对应激反应和衰老的新见解。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0.

DOI：
10.1093/genetics/iyac085
发表时间：
2022-07-30
期刊：
GENETICS
影响因子：
3.3
作者：
Higgins, Daniel P.;Weisman, Caroline M.;Lui, Dominique S.;D'Agostino, Frank A.;Walker, Amy K.
通讯作者：
Walker, Amy K.