Music4Pain Network: A research network to advance the study of mechanisms underlying the effects of music and music-based interventions on pain.

项目总结/摘要 疼痛是世界上最常见和最昂贵的健康问题之一。部分原因是， 纯粹的生物医学方法，许多人越来越多地寻求补充方法来治疗疼痛， 包括基于音乐的干预（MBIs）。虽然MBIs的止痛效果很好， 对MBIs的作用机制缺乏了解，使我们无法充分利用它们的治疗方法。 抽搐电位为了让音乐和疼痛的机制研究以一种高效而严谨的方式取得进展- 建立一支能够领导创新机制研究的多学科研究队伍， needed.为此，我们建议创建Music 4Pain网络，这是一个多学科研究网络， 将汇集神经科学家，音乐治疗师，音乐家，神经心理学家，康复科学家， 心理生理学家等等。Music 4Pain网络旨在加速三个关键领域的知识：（1） 制定与MBIs和音乐相关的关键术语和定义的分类法，（2）增加理解- 研究音乐对疼痛的益处的潜在机制，以及（3）识别生物标志物和per-pain。 预测MBI治疗反应的子变量。网络活动将由一个正式的研究指导 该议程将由网络的核心研究小组与科学家合作制定， 补充专业知识。Music 4Pain网络将通过以下方式建立新的多学科研究合作： (1)积极推动跨学科网络，以招募相关和免费的专家， （2）建立一个互动的网络网站，以确定潜在的合作者，分享， 资源整合，网络活动和产品的特色化，（3）利用社交媒体推广网络， dia平台，以及（4）组织年度会议，网络研讨会，以及音乐和疼痛特别兴趣小组。在 此外，Music 4Pain网络还将通过试点，促进创新性的、多学科的机制研究。 经费试点资金将支持收集创新数据，以加强独立研究 资助申请。该网络还将资助访问学者职位，以帮助博士生和博士后， 部门研究员获得与网络目标有关的技能和专门知识。此外，网络将建立音乐和 通过指导新的和早期的职业调查人员，以发展研究技能和超级疼痛研究队伍， 努力获取校外资金这项工作将通过Music 4Pain 网络将能够开发新的或优化现有的MBIs， 可以更好地管理与低成本，非药物的方法，具有广泛的吸引力， 的人。提高MBIs的功效并更好地了解其作用机制将加快 在临床护理中的应用。这可能会对目前数百万美国人产生重要影响。 活在痛苦中

PROJECT SUMMARY/ABSTRACT Pain is one of the most common and costly health problems worldwide. Due in part to the inadequacies of purely biomedical approaches, many people are increasingly seeking complementary approaches to pain man- agement, including music-based interventions (MBIs). Although the pain-relieving effects of MBIs are well-es- tablished, lack of understanding of MBIs' mechanisms of action prevents us from exploiting their full therapeu- tic potential. In order for mechanistic research on music and pain to progress in an efficient and rigorous man- ner, the building of a multidisciplinary research workforce capable of leading innovative mechanistic studies is needed. To this end, we propose to create the Music4Pain Network, a multidisciplinary research network that will bring together neuroscientists, music therapists, musicians, neuropsychologists, rehabilitation scientists, psychophysiologists, and more. The Music4Pain Network aims to accelerate knowledge in three key areas: (1) development of a taxonomy of key terms and definitions related to MBIs and music, (2) increased understand- ing of the mechanisms underlying the benefits of music for pain, and (3) identification of biomarkers and per- son variables that predict treatment response to MBIs. Network activities will be guided by a formal research agenda that will be developed by the Network's Core Investigator Team in collaboration with scientists with complementary expertise. The Music4Pain Network will forge new multidisciplinary research collaborations by (1) actively promoting the Network across disciplines to recruit experts with relevant and complimentary knowledge, (2) building an interactive Network website to enable identification of potential collaborators, shar- ing of resources, and featuring of Network activities and products, (3) promoting the Network using social me- dia platforms, and (4) organizing annual meetings, webinars, and Music and Pain Special Interest Groups. In addition, the Music4Pain Network will stimulate innovative, multidisciplinary mechanistic research through pilot funding. The pilot funding will support the collection of innovative data to strengthen independent research funding applications. The Network will also fund Visiting Scholar positions to help PhD students and postdoc- toral fellows gain skills and expertise related to Network goals. In addition, the Network will build the music and pain research workforce by mentoring new and early career investigators to develop research skills and sup- port their efforts in obtaining extramural funding. The work that will be made possible through the Music4Pain Network will enable the development of new, or optimization of existing, MBIs so that acute and chronic pain can be better managed with a low-cost, non-pharmacological approach that has wide appeal to a large number of people. Improved efficacy of MBIs and better understanding of their mechanisms of action will speed up their adoption in clinical care. This could have important consequences for the millions of Americans currently living with pain.