UNC Immunotherapy Training Grant (IM-TAG)

北卡罗来纳大学免疫治疗培训补助金 (IM-TAG)

• 批准号: 10767617
• 负责人: Jonathan S. Serody
• 金额: $ 16.51万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10767617
• 关键词: Grant; Immunotherapy; Training

Abstract: This is a training program from the University of North Carolina at Chapel Hill (UNC-CH) to train postdoctoral fellows in basic, translational or clinical research focusing on tumor immunotherapy, tumor immunology or stem cell transplantation immunology. The UNC Immunotherapy Training Grant (IM-TAG) is led by an exceptional mentor, Jonathan Serody MD, who is assisted by two superb Associate Directors in Barbara Savoldo MD PhD and Benjamin Vincent MD. This training proposal is supported by a nationally renowned mentorship group and exceptional facilities for translation of tumor and transplantation immunology to the clinic. Additionally, there are world-class investigators that make up the Internal Advisory Committee and External Advisory Board. The focus of IM-TAG is significantly underrepresented in training programs leading to a paucity of investigators working in these areas. IM-TAG supports the training of two postdoctoral fellows yearly. There are 11 Professors, and eight Associate Professors, with outstanding qualifications who serve as mentors. We have identified two exceptional Assistant Professors, who serve as co-mentors. These investigators’ interests include 1) vaccine design and vector generation, 2) adoptive cellular therapy, 3) the role of immune cells in the tumor microenvironment (TME), 4) immunogenomic assessment of TME, 5) enhancing our understanding of the biology of the graft-versus-tumor response and 6) approaches to manage acute and chronic graft-versus-host disease. There are innovative mechanisms for training that include 1) didactic coursework in statistical design, 2) immunogenomic coursework and data evaluation overseen by world experts in tumor immunogenomics, and 3) participation in Immunotherapy Working Groups, which are translational teams that assist in the development of novel immunotherapies, allowing trainees to be involved in the development of INDs and clinical trials. We have a comprehensive approach to training underrepresented minorities, including a summer course for undergraduate students to provide them with hands-on experience in immunotherapy or transplantation immunology. Strengths of the program include 1) an extremely well-funded group of mentors with substantial experience training postdoctoral fellows, 2) an outstanding leadership group with a long history of leading collaborative research proposals, 3) and the presence of a world-class vaccine and transplantation infrastructure that trainees can access. This program combines the mentors, foundation, and resources of a nationally recognized tumor immunology, cancer immunotherapy and transplantation immunology program with novel approaches to enhance the vertical training of underrepresented individuals and enhance the bench to bedside development of therapeutics by individuals who are trained in this program.

抽象的： 这是北卡罗来纳大学教堂山分校 (UNC-CH) 为培养博士后而举办的培训项目 专注于肿瘤免疫治疗、肿瘤免疫学或干细胞基础、转化或临床研究的研究员 细胞移植免疫学。北卡罗来纳大学免疫治疗培训补助金 (IM-TAG) 由一位杰出的 导师 Jonathan Serody 医学博士，并得到 Barbara Savoldo 医学博士两位出色副主任的协助 和本杰明·文森特医学博士。该培训计划得到了全国知名导师团队的支持 将肿瘤和移植免疫学转化为临床的卓越设施。此外，还有 内部咨询委员会和外部咨询委员会由世界一流的调查员组成。焦点 IM-TAG 在培训计划中的代表性明显不足，导致从事以下工作的研究人员很少 这些领域。 IM-TAG每年支持培养两名博士后。现有教授11人，副教授8人 具有杰出资历的教授担任导师。我们已经确定了两名杰出的助理 教授，担任共同导师。这些研究人员的兴趣包括 1) 疫苗设计和载体 第一代，2) 过继细胞疗法，3) 免疫细胞在肿瘤微环境 (TME) 中的作用，4) TME 的免疫基因组学评估，5) 增强我们对移植物抗肿瘤生物学的理解 反应和6) 处理急性和慢性移植物抗宿主病的方法。有创新的 培训机制包括 1) 统计设计教学课程，2) 免疫基因组课程 由世界肿瘤免疫基因组学专家监督的数据评估，以及 3) 参与免疫治疗 工作组是协助开发新型免疫疗法的翻译团队， 允许学员参与 IND 的开发和临床试验。我们有全面的 培训代表性不足的少数群体的方法，包括为本科生提供暑期课程 为他们提供免疫治疗或移植免疫学的实践经验。 该计划的优势包括 1) 资金雄厚、经验丰富的导师团队 培养博士后研究员，2）具有长期领导协作历史的优秀领导团队 研究提案，3) 以及受训者能够获得世界一流的疫苗和移植基础设施 可以访问。该项目结合了国家认可的肿瘤的导师、基金会和资源 免疫学、癌症免疫治疗和移植免疫学项目，采用新方法 加强对代表性不足的个人的垂直培训，并加强从替补到床边的发展 由接受过该计划培训的个人进行治疗。