Comp A: CALIFORNIA CENTER OF BD-STEPS III FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS

比较 A：加州 BD-STEPS III 中心寻找出生缺陷的原因和预防措施

• 批准号: 10764184
• 负责人: GARY M SHAW
• 金额: $ 60万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764184
• 关键词: Comp; CALIFORNIA; CENTER; BD; STEPS

ABSTRACT Birth defects are the leading cause of infant mortality in the US. Birth defects also have enormous associated emotional and economic costs. The California Center's research efforts, both independently and in collaboration with other Centers for Birth Defects Research and Prevention contributing to the National Birth Defects Prevention Study (NBDPS) and the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS), have been at the forefront of public health birth defects research. With this new funding opportunity, referred to here as “BD- STEPS III” to distinguish from earlier BD-STEPS programs initiated in 2013 (BD-STEPS I) and 2018 (BD-STEPS II), our Center will further enhance scientific understanding of the potential causes of specific birth defects, which will undoubtedly have important implications for risk assessment and prevention of common, costly, and deadly birth defects. In this application we propose the following aims: Aim 1: Enhance the epidemiologic public health research capacity of the Centers for Birth Defects and Research and Prevention by actively participating in BD-STEPS III in a region of the US that is highly diverse in its race/ethnicity, socioeconomic characteristics, and environmental exposures. Aim 2: Utilize data from BD-STEPS I-III, as well as the earlier NBDPS (and likely other data sources unique to California), to conduct rigorous collaborative and local studies that will identify potential modifiable risk factors for selected birth defects (and where appropriate, in combination with genetic susceptibility) to reduce the public health burden of birth defects in the US. The California Center is well-equipped to contribute to BD-STEPS III – it is a world leader in birth defects epidemiology and highly experienced in the development, data collection and dissemination of information from population-based studies of birth defects, exemplified by its outstanding performance within the CDC Centers for Birth Defects Research and its highly innovative research portfolio. The application describes how the California Center will accomplish Aims 1 and 2 and will thereby further the knowledge base about causes and prevention for human birth defects. The California Center has extensive experience conducting research related to the BD-STEPS III areas of focus, which include maternal chronic diseases and their treatment, infectious disease in pregnancy, and medications. We have proposed several analytic inquiries, complemented by the use of additional innovative datasets and analytic approaches, which will enable us to collaboratively continue elucidating the contribution of these and other modifiable risk factors to birth defects.

摘要 出生缺陷是美国婴儿死亡的主要原因。出生缺陷也有 巨大的情感和经济代价。加州中心的研究成果， 无论是独立还是与其他出生缺陷研究中心合作， 预防有助于国家出生缺陷预防研究（NBDPS）和出生 缺陷研究，以评估怀孕暴露（BD-STEPS），一直处于前列， 公共卫生出生缺陷研究。有了这个新的融资机会，这里称为“BD- STEPS III”，以区别于2013年启动的早期BD-STEPS计划（BD-STEPS I）， 2018年（BD-STEPS II），我们的中心将进一步提高对潜力的科学认识 特定出生缺陷的原因，这无疑将对风险产生重要影响 评估和预防常见、昂贵和致命的出生缺陷。在本申请中，我们 提出以下目标： 目标1：提高生育中心的流行病学公共卫生研究能力 通过积极参与BD-STEPS III， 美国在种族/民族、社会经济特征和 环境暴露。 目标2：利用BD-STEPS I-III以及早期NBDPS的数据（以及可能的其他数据 来源独特的加州），进行严格的合作和当地的研究，将确定 某些出生缺陷的潜在可改变的风险因素（以及在适当情况下， 具有遗传易感性），以减少美国出生缺陷的公共卫生负担。 加州中心拥有完善的设备，可以为BD-STEPS III做出贡献--它在以下方面处于世界领先地位： 出生缺陷流行病学和丰富的经验，在发展，数据收集和 传播以人口为基础的出生缺陷研究的信息， 在CDC出生缺陷研究中心的杰出表现及其高度 创新的研究组合。该应用程序描述了加州中心将如何 实现目标1和目标2，从而将进一步加深关于原因的知识基础， 预防人类出生缺陷。加州中心在开展 与BD-STEPS III重点领域相关的研究，包括孕产妇慢性病 以及他们的治疗，怀孕期间的传染病和药物。我们提出 几个分析调查，辅之以使用额外的创新数据集， 分析方法，这将使我们能够合作继续阐明贡献 这些和其他可改变的出生缺陷风险因素。