Developing an Interdisciplinary Research Agenda for Genetics of Birth Defects

制定出生缺陷遗传学跨学科研究议程

基本信息

  • 批准号:
    8526145
  • 负责人:
  • 金额:
    $ 3.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-04-01 至 2016-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Human structural birth defects are often associated with physical or mental disability and are the leading cause of infant mortality in the US. The medical, economic, social, and family implications of birth defects are tremendous. For several decades the scientific community has stated that as many as 75% of birth defects have an unknown cause and only a small percentage of causes can be attributed to infections, environmental toxins, and a limited number of known genetic effects. Our limited knowledge regarding genetic (and nongenetic) factors that impact occurrence of most human birth defects is partly rooted in what has historically been a lack of data resources and limits on technology. We currently have an unprecedented opportunity to advance genomic research of birth defects. However, next steps toward capitalizing on such opportunities have obstacles. Primary among the obstacles is a lack of a coordinated interdisciplinary research agenda for the study of genetic etiologies and birth defects. In this application, we are proposing an initial effort towar solving such obstacles by having a 2-day workshop. The goal of the proposed workshop is to identify approaches and formulate strategies that are likely to have a substantial and sustained impact on discovering genomic and epigenomic risk factors for human birth defects. The workshop has been structured to optimize productive and engaging interactions between scientists with multiple point-counter point formal discussions on five pertinent topical areas. The meeting will assemble leading scientists from manifold disciplines including teratology, genetics, epidemiology, pediatrics, obstetrics, and molecular biology. The outcome of this meeting will be a comprehensive "white paper" that will characterize the discussions and provide a detailed prospectus for new research trajectories that can be broadly distributed.
描述(由申请人提供):人类结构性出生缺陷通常与身体或精神残疾有关,是美国婴儿死亡的主要原因。出生缺陷的医学、经济、社会和家庭影响是巨大的。几十年来,科学界一直表示,多达75%的出生缺陷原因不明,只有一小部分原因可归因于感染、环境毒素和有限数量的已知遗传影响。我们对影响大多数人类出生缺陷发生的遗传(和非遗传)因素的知识有限,部分原因是历史上缺乏数据资源和技术限制。我们目前有一个前所未有的机会来推进出生缺陷的基因组研究。然而,利用这些机会的下一步行动存在障碍。主要的障碍是缺乏一个协调的跨学科研究议程来研究遗传病因和出生缺陷。在这个应用程序中,我们建议通过为期两天的研讨会来解决这些障碍。本次研讨会的目标是确定可能对发现人类出生缺陷的基因组和表观基因组风险因素产生重大和持续影响的方法和制定策略。研讨会的结构旨在优化科学家之间富有成效和引人入胜的互动,并就五个相关主题领域进行多点对点的正式讨论。会议将聚集来自多个学科的顶尖科学家,包括畸形学、遗传学、流行病学、儿科、产科和分子生物学。这次会议的结果将是一份全面的“白皮书”,其中将描述讨论的特点,并为可以广泛分发的新研究轨迹提供详细的说明书。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GARY M SHAW其他文献

GARY M SHAW的其他文献

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{{ truncateString('GARY M SHAW', 18)}}的其他基金

Comp A: CALIFORNIA CENTER OF BD-STEPS III FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS
比较 A:加州 BD-STEPS III 中心寻找出生缺陷的原因和预防措施
  • 批准号:
    10764184
  • 财政年份:
    2023
  • 资助金额:
    $ 3.6万
  • 项目类别:
CALIFORNIA CENTER OF BD-STEPS II FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS
加州 BD-STEPS II 中心寻找出生缺陷的原因和预防措施
  • 批准号:
    9766981
  • 财政年份:
    2018
  • 资助金额:
    $ 3.6万
  • 项目类别:
CALIFORNIA CENTER OF BD-STEPS II FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS
加州 BD-STEPS II 中心寻找出生缺陷的原因和预防措施
  • 批准号:
    10421031
  • 财政年份:
    2018
  • 资助金额:
    $ 3.6万
  • 项目类别:
CALIFORNIA CENTER OF BD-STEPS II FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS
加州 BD-STEPS II 中心寻找出生缺陷的原因和预防措施
  • 批准号:
    10264765
  • 财政年份:
    2018
  • 资助金额:
    $ 3.6万
  • 项目类别:
Pesticide Exposures and Risk of Preterm Birth
农药接触和早产风险
  • 批准号:
    8741980
  • 财政年份:
    2013
  • 资助金额:
    $ 3.6万
  • 项目类别:
Pesticide Exposures and Risk of Preterm Birth
农药接触和早产风险
  • 批准号:
    9094597
  • 财政年份:
    2013
  • 资助金额:
    $ 3.6万
  • 项目类别:
Pesticide Exposures and Risk of Preterm Birth
农药接触和早产风险
  • 批准号:
    8629564
  • 财政年份:
    2013
  • 资助金额:
    $ 3.6万
  • 项目类别:
Project 2: Exposure to Air Pollutants and Risk of Birth Defects
项目 2:接触空气污染物和出生缺陷的风险
  • 批准号:
    8215033
  • 财政年份:
    2011
  • 资助金额:
    $ 3.6万
  • 项目类别:
Project 2: Exposure to Air Pollutants and Risk of Birth Defects
项目 2:接触空气污染物和出生缺陷的风险
  • 批准号:
    7850144
  • 财政年份:
    2010
  • 资助金额:
    $ 3.6万
  • 项目类别:
Teratology Society 49th Annual Meeting: Student and Postdoctoral Travel Awards
畸胎学协会第 49 届年会:学生和博士后旅行奖
  • 批准号:
    7743694
  • 财政年份:
    2009
  • 资助金额:
    $ 3.6万
  • 项目类别:

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