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Gaps and Determinants in PrEP Uptake and Need: Understanding Disparities in PrEP Among Women in the United States

PrEP 采用和需求方面的差距和决定因素：了解美国女性 PrEP 方面的差异

基本信息

批准号：
10762821
负责人：
Brady W Bennett
金额：
$ 4.77万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10762821
关键词：
AIDS prevention Affect African American Behavior Behavioral Black race Categories Characteristics Data Data Set Databases Diagnosis Disparate Disparity Eligibility Determination Epidemic Epidemiology Equation Equity Ethnic Origin Evaluable Disease Family Geography Goals Government Growth Guidelines HIV HIV Infections HIV diagnosis HIV risk Health Personnel Heterosexuals Hispanic Inequity Infection Knowledge Latinx population Logistic Regressions Methodology Methods Modeling Oral Pattern Performance Pharmacologic Substance Pharmacy facility Policies Public Health Race Records Research Risk Risk Factors Sexual Partners Socioeconomic Status Spatial Distribution Surveys Training United States United States Dept. of Health and Human Services Woman Work black women career comparative data quality health equity low socioeconomic status male men men who have sex with men pre-exposure prophylaxis sex sociodemographic factors spatiotemporal statistics uptake validation studies

项目摘要

ABSTRACT Women accounted for 18% of new HIV diagnoses in the United States in 2020 and yet only 7.4% of the pre- exposure prophylaxis (PrEP) users. Additionally, 71% of the women diagnosed with HIV in 2020 were Black/African American or Hispanic. PrEP has been shown to reduce incident HIV infection, providing a substantial public health opportunity to work towards the US Department of Health and Human Services announced the Ending the HIV Epidemic initiative. However, a substantial component of risk of HIV infection for women relates to the behaviors of their male sex partners, and these risks of partners may be unknown to women. Additionally, the completeness of data on race/ethnicity in key datasets used to document PrEP users in the US is limited leading to bias in our estimates. The proposed analysis will (1) determine the characteristics of women based on their partnerships that are indications for PrEP, particularly those indications unrecognized by women and their healthcare providers, 2) use multiple imputation to complete race/ethnicity data in current pharmaceutical use datasets to better understand the current racial/ethnic distribution of women PrEP users, and 3) analyze spatio-temporal patterns of PrEP uptake among women in the United States. Taken together, the goal of this proposal is to advance our understanding of among whom PrEP is needed, racial/ethnicity distributions among whom PrEP is currently being utilized, and where uptake is disparate considering risk factors for HIV infection.

摘要 2020年，女性占美国艾滋病新诊断病例的18%，但仅占艾滋病前诊断病例的7.4%。暴露预防（PrEP）使用者。此外，2020年被诊断感染艾滋病毒的妇女中有71%是黑人/非裔美国人或西班牙裔。PrEP已被证明可以减少艾滋病毒感染事件，向美国卫生与公众服务部提供大量公共卫生机会宣布了终止艾滋病毒流行的倡议。然而，艾滋病毒感染风险的一个重要组成部分，女性与男性性伴侣的行为有关，而伴侣的这些风险可能不为人所知妇女此外，用于记录PrEP用户的关键数据集中种族/民族数据的完整性在美国，这一数字有限，导致我们的估计存在偏差。建议的分析将（1）确定特征基于其伴侣关系的妇女，这些伴侣关系是PrEP的指征，特别是那些未被承认的指征由女性及其医疗保健提供者，2）使用多重插补来完成目前的人种/种族数据药物使用数据集，以更好地了解女性PrEP使用者的当前种族/民族分布，和3）分析美国妇女中PrEP摄取的时空模式。综合起来看，该提案的目标是促进我们对需要PrEP的人，种族/民族的理解目前正在使用PrEP的分布，考虑到风险因素，艾滋病病毒感染。