Circadian Clock and Myc-dependent Regulation of Cellular Transformation

生物钟和细胞转化的 Myc 依赖性调节

• 批准号: 10767049
• 负责人: Selma Masri
• 金额: $ 13.54万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10767049
• 关键词: ARNTL gene; Acceleration; Address; Administrative Supplement; Adult; Award; Biological Assay; Cell Proliferation; Circadian Dysregulation; Circadian Rhythms; Circadian gene expression; Code; Colorectal Cancer; Complex; Computer Analysis; Coupled; DNA Damage; Data; Death Rate; Development; Diagnostic Neoplasm Staging; Dietary Factors; Down-Regulation; Environmental Risk Factor; Enzymes; Funding; Genes; Genetic; Genome; Genome Stability; Genomic Instability; High Fat Diet; Human; Intestinal Polyps; Intestines; Link; Loss of Heterozygosity; Malignant Neoplasms; Maps; Measures; Mediating; Metabolic; Metabolic Pathway; Metabolism; Modeling; Molecular; Mus; Mutation; Oncogenic; Organoids; Parents; Pathogenesis; Pathway interactions; Patients; Peroxisome Proliferator-Activated Receptors; Prevention strategy; Proliferating; Reporting; Research; Risk Factors; Signal Transduction; Stress; Surveys; Survival Rate; System; Testing; The Cancer Genome Atlas; Time-restricted feeding; WNT Signaling Pathway; biobank; c-myc Genes; cancer prevention; cancer type; cell growth regulation; circadian; circadian pacemaker; circadian regulation; colon cancer patients; dietary control; early onset colorectal cancer; exome sequencing; experimental study; human data; interdisciplinary approach; intestinal epithelium; knock-down; metaplastic cell transformation; mouse model; novel; nutrition; older patient; parent grant; pharmacologic; reconstitution; response; stable isotope; stemness; supplemental instruction; transcription factor; transcriptome; tumorigenesis

The supplement instructions for PAR-22-114 state: “At a minimum, the Research Strategy section should be completed and must include a summary or abstract of the funded parent award or project. Other sections should also be included if they are being changed by the proposed supplement activities.” The original Project Summary / Abstract document has not changed as a result of the proposed supplement activities.

PAR-22-114的补充说明指出：“至少，研究策略