Dissecting the causal impact of prenatal HIV exposure and the postnatal environment on development in Malawian Infants
剖析产前艾滋病毒暴露和产后环境对马拉维婴儿发育的因果影响
基本信息
- 批准号:10762850
- 负责人:
- 金额:$ 15.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:5 year oldAccountingAddressAfrica South of the SaharaAgeAreaBioinformaticsBiologicalBiostatistical MethodsBirthBlood specimenChildChild DevelopmentChild HealthChildhoodClinicCohort StudiesCommunicable DiseasesComplexDataData SetData SourcesDevelopmentDevelopment PlansDimensionsEnrollmentEnvironmentEnvironmental Risk FactorEpidemiologistEquationEtiologyEvaluationExposure toFacultyFlow CytometryFrequenciesGoalsGrowthHIVHIV InfectionsHIV-exposed uninfected infantHealthHome environmentImmuneImmunityImmunologic MarkersImmunologicsImmunologyImpairmentInfantInfant DevelopmentInfant HealthInfectionInfectious Disease EpidemiologyInfectious Diseases ResearchInflammationInflammatoryInterdisciplinary StudyInterventionLanguage DevelopmentLeadershipLifeMachine LearningMalawiMarylandMaternal and Child HealthMeasuresMental HealthMentorsMethodological StudiesMethodologyMethodsModelingMother-Child RelationsMothersMotorNatureNeonatalNeurocognitiveNeurocognitive DeficitOutcomePregnancyPrincipal InvestigatorProductivityPublic HealthResearchResearch MethodologyResearch PersonnelRiskSecond Pregnancy TrimesterSeverity of illnessSocial BehaviorSocioeconomic StatusT-LymphocyteTechniquesTestingTrainingUmbilical Cord BloodUniversitiesarmcareercareer developmentcausal modelcohortcomplex datadata integrationdesigndisease transmissiondiverse dataearly childhoodeffective interventionefficacious interventionexamination questionsexecutive functionfollow-upglobal healthimmunological statusimprovedinnovationinterdisciplinary approachlarge datasetsmaternal wellbeingmedical schoolsmultidisciplinaryneonatal immunityneurodevelopmentnovelpostnatalprenatalprenatal exposurepsychosocialskillstherapy designtransmission process
项目摘要
PROJECT SUMMARY/ABSTRACT
Infant health and neurodevelopment in early life may be impaired by a wide range of prenatal and postnatal
factors including maternal infection and inflammation, and the socio-behavioral postnatal environment.
Identifying the independent impact of these exposures is critical for defining key interventions to improve infant
health and development. This proposal addresses a long-standing challenge in examining multifactorial
outcomes such as neurocognitive development that require incorporating both biological and psychosocial
exposures. The Principal Investigator, Dr. Andrea Buchwald, is an infectious disease epidemiologist at
University of Maryland School of Medicine with expertise in biostatistical methods and global health. She will
use multidisciplinary methodology to address this challenge, examining the independent contributions of
prenatal and postnatal exposures on child health and development in a cohort including HIV exposed and
uninfected infants. Using data from an on-going cohort study in Malawi, Dr. Buchwald will be uniquely able to
develop an innovative statistical approach to examine the contribution of both biological and socio-behavioral
factors on infant health and development. Mothers with and without HIV infection were enrolled in their second
trimester of pregnancy and infants are being followed up through five years of age for health and development
outcomes. Dr. Buchwald will use a multidisciplinary approach, combining machine learning and structural
equation modeling, to address the following aims:
Aim 1: Estimate the independent contributions of in utero exposure to HIV and postnatal environmental factors
on infant health and neurocognitive development.
Aim 2: Identify immunological profiles at birth predictive of infant health and neurocognitive development.
The results of this research will help us to identify key intervention targets for improving child health and
development, to inform intervention design and implementation.
Dr. Buchwald’s goal is to become an independent investigator in in pediatric infectious disease, with
expertise in utilizing cross-disciplinary methodology to address the multifactorial nature of infectious disease.
Towards this goal, she proposes a comprehensive career development plan that will enhance her existing
skills in infectious disease epidemiology while providing mentored training in 1) data integration of large
datasets, 2) socio-behavioral methodology, 3) analyzing large biological datasets, and 4) leadership skills.
Dr. Buchwald has assembled a highly accomplished multidisciplinary team of mentors with unique
areas of expertise including global health research, maternal/child health, neonatal immunology,
bioinformatics, structural equation modeling, and neurodevelopment. Her mentors have a track record of
successfully mentoring trainees and junior faculty and the University of Maryland School of Medicine will
provide the ideal environment for Dr. Buchwald to establish a productive independent research career.
项目总结/文摘
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrea G. Buchwald其他文献
Systematic review of analytical methods applied to longitudinal studies of malaria
- DOI:
10.1186/s12936-019-2885-9 - 发表时间:
2019-07-29 - 期刊:
- 影响因子:3.000
- 作者:
Christopher C. Stanley;Lawrence N. Kazembe;Mavuto Mukaka;Kennedy N. Otwombe;Andrea G. Buchwald;Michael G. Hudgens;Don P. Mathanga;Miriam K. Laufer;Tobias F. Chirwa - 通讯作者:
Tobias F. Chirwa
Andrea G. Buchwald的其他文献
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