Preclinical Evaluation of Radioprotectin-1 for Mitigation of GI-ARS

Radioprotectin-1 缓解 GI-ARS 的临床前评估

• 批准号: 10770849
• 负责人: France Carrier
• 金额: $ 2.33万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-27 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10770849
• 关键词: Acceleration; Agonist; Apoptotic; Benzoic Acids; Biological Assay; Bone Marrow; Cell Survival; Cells; Cessation of life; Collaborations; Colon; Complex; DNA Integration; DNA Repair; Development; Dose; Drug Formulations; Drug Kinetics; Drug Targeting; Enzymes; Evaluation; Formulation; G-Protein-Coupled Receptors; Generations; Genes; Genotoxic Stress; Growth Factor; Hematopoietic; Hematopoietic stem cells; Human; Induction of Apoptosis; Inhibition of Apoptosis; Injury; Intestines; Investigational Drugs; Laboratories; Lethal Dose 50; Leucine-Rich Repeat; Lysophosphatidic Acid Receptors; MAPK3 gene; Macaca mulatta; Mediating; Modeling; Molecular Mechanisms of Action; Mus; NF-kappa B; Natural regeneration; Organ; Pathology; Pathway interactions; Pharmaceutical Preparations; Pharmacy facility; Property; Protein phosphatase; Proto-Oncogene Proteins c-akt; Radiation; Radiation Dose Unit; Radiation Induced DNA Damage; Radiation Protection; Radiation Toxicity; Radiation induced damage; Signal Transduction; Testing; Therapeutic; Toxicokinetics; analog; cell regeneration; cellular targeting; college; drug candidate; drug development; drug discovery; efficacy study; experience; gastrointestinal; gastrointestinal epithelium; gene product; in vivo; irradiation; lipid mediator; lysophosphatidic acid; mortality; nanoparticle; nanoparticle drug; nonhuman primate; preclinical evaluation; prevent; programs; radiation countermeasure; radiation mitigation; radiation mitigator; receptor; recruit; regenerative; senescence; small molecule; stem cell survival; stem cells

Project Abstract Project Abstract has not changed from original submission

项目摘要 项目摘要与最初提交的内容相比没有变化

项目成果

Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5.

• DOI: 10.3389/fimmu.2023.1174140
• 发表时间: 2023
• 期刊: Frontiers in immunology
• 影响因子: 7.3