Electronic cigarette use in lung cancer patients

肺癌患者使用电子烟

• 批准号: 10768042
• 负责人: Theodore M. Brasky
• 金额: $ 18.66万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10768042
• 关键词: Adult; Advocate; Affect; Area; Authorization documentation; Behavioral Research; COVID-19; Cancer Patient; Cancer Survivor; Cigarette; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Comprehensive Cancer Center; Data; Data Collection; Development; Diagnosis; Electronic Nicotine Delivery Systems; Electronic cigarette; Environment; Epidemiologist; Excision; Fostering; Funding; Future; General Population; Goals; Guidelines; Head Cancer; Health; Health Benefit; Institution; Interruption; Intervention; Intervention Studies; Investigation; Malignant Neoplasms; Malignant neoplasm of lung; Marketing; Measures; Mentors; Metabolism; National Comprehensive Cancer Network; Neck Cancer; Observational Study; Ohio; Operative Surgical Procedures; Outcome; Patient Recruitments; Patients; Perioperative complication; Policies; Population; Positioning Attribute; Professional Organizations; Public Health; Quality of life; Quasi-experiment; Reporting; Request for Proposals; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Project Grants; Safety; Sample Size; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Surgeon; Surgical complication; Symptoms; Tobacco; Tobacco-Related Carcinoma; Toxic effect; Training; Treatment-related toxicity; United States; United States Food and Drug Administration; Universities; authority; cancer epidemiology; cancer survival; career development; chemotherapy; cigarette smoking; cohort; combustible cigarette; coronavirus disease; design; editorial; electronic cigarette use; evidence base; experience; exposure to cigarette smoke; follow-up; hospital utilization; improved; member; novel; patient population; randomized trial; response; safety assessment; skills; smoking cessation; sound; standard of care; symptomatology; tobacco control; tobacco products; tobacco regulatory science; tool; treatment as usual; treatment guidelines

TITLE: Electronic Cigarette Use in Head, Neck, and Lung Cancer Patients PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to facilitate Dr. Theodore Brasky’s development into an established and independent investigator for tobacco control. For this research, he will focus on cancer patients and the impact of electronic cigarettes (e-cigs) on cigarette smoking, quitting, and health outcomes. It is established that cigarette smoking adversely affects the cancer patient in many ways. E-cigs have the potential to reduce cigarette smoke exposures, related toxicities, and foster smoking cessation. However, almost no research exists to substantiate this hypothesis. Dr. Brasky is a cancer epidemiologist and member of the Ohio State University Comprehensive Cancer Center (OSUCCC) with considerable expertise in the analysis and interpretation of longitudinal data. Due to a strong institutional environment, he has been participating in various tobacco-focused research projects over the past several years. Excited by this, he wants to take advantage of the extraordinary opportunities in tobacco control related to e-cigs. The proposed training plan will enable him to obtain expertise and experience in tobacco research (e.g., coursework in tobacco regulatory science), intervention studies (e.g., coursework in clinical research methods and translational behavioral research), and primary data collection in complementary studies. This training will capitalize on the exceptional institutional environment at OSU and an experienced mentor in tobacco control in Dr. Peter Shields, Deputy Director of the OSUCCC. Herein, Dr. Brasky will address critical research gaps that will aid in the understanding for the impact of e-cigs on the cancer patient generally, and specifically for the creation of sound policy decisions by the Food and Drug Administration. This proposal requests a funded extension to complete Dr. Brasky’s research goals due to significant COVID-19 related interruptions. The Specific Aims are to: 1) analyze an observational cohort of 184 head, neck, and lung cancer patients and examine the associations of e-cigs with smoking reduction, smoking cessation, quality of life, and treatment toxicities; and, 2) Evaluate feasibility, acceptability, compliance, and safety of a pilot patient-choice trial of a pod-based e-cig versus standard of care in 40 head, neck, and lung cancer patients planning to undergo surgical resection. These complementary studies will be among the first to examine associations in patients with tobacco-related cancers and will share assessment measures. Results from this research will yield critical data in order to provide sound and evidence-based decisions on e-cigs.

标题：电子烟在头颈癌和肺癌患者中的使用 项目概要/摘要 该提案的总体目标是促进 Theodore Brasky 博士发展成为一个成熟的、 烟草控制独立调查员。在这项研究中，他将重点关注癌症患者及其影响 电子烟（e-cigs）对吸烟、戒烟和健康结果的影响。确定 吸烟在很多方面对癌症患者产生不利影响。电子烟有可能减少 香烟烟雾暴露、相关毒性并促进戒烟。但几乎没有研究 的存在就是为了证实这个假设。 Brasky 博士是一位癌症流行病学家，也是俄亥俄州立大学的成员 大学综合癌症中心 (OSUCCC) 在分析和治疗方面拥有丰富的专业知识 纵向数据的解释。由于强大的制度环境，他一直参与 过去几年各种以烟草为重点的研究项目。他对此感到兴奋，想要采取 利用与电子烟相关的烟草控制的绝佳机会。拟议的培训计划 将使他能够获得烟草研究方面的专业知识和经验（例如，烟草监管课程） 科学）、干预研究（例如临床研究方法和转化行为学课程） 研究），以及补充研究中的主要数据收集。此次培训将利用特殊的 俄勒冈州立大学 (OSU) 的制度环境以及副教授彼得·希尔兹 (Peter Shields) 博士在烟草控制方面经验丰富的导师 OSUCCC 主任。在此，布拉斯基博士将解决关键的研究空白，这将有助于 了解电子烟对癌症患者的总体影响，特别是对声音产生的影响 食品药品监督管理局的政策决定。该提案要求资助延期以完成 Brasky 博士的研究目标因与 COVID-19 相关的重大中断而中断。具体目标是：1) 分析了 184 名头颈癌和肺癌患者的观察队列，并检查了以下因素之间的关联： 电子烟具有减少吸烟、戒烟、提高生活质量和治疗毒性的作用；以及，2) 评估 基于烟弹的电子烟与患者选择试点试验的可行性、可接受性、合规性和安全性 40 名计划接受手术切除的头颈癌和肺癌患者的标准护理。这些 补充研究将是首批检查烟草相关癌症患者之间关系的研究之一 并将分享评估措施。这项研究的结果将产生关键数据，以便提供 关于电子烟的合理且基于证据的决策。