Electronic cigarette use in lung cancer patients

肺癌患者使用电子烟

• 批准号: 10087897
• 负责人: Theodore M. Brasky
• 金额: $ 16.51万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10087897
• 关键词: Address; Adherence; Adult; Advisory Committees; Advocate; Affect; Area; Behavioral Research; Benefits and Risks; Cancer Center; Cancer Patient; Chest; Cigarette; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Comprehensive Cancer Center; Counseling; Country; Data; Data Collection; Development; Devices; Electronic Nicotine Delivery Systems; Electronic cigarette; Environment; Epidemiologist; Excision; Fostering; Funding; Future; General Population; Goals; Guidelines; Health; Health Benefit; Health Promotion; Health behavior; Institution; Intervention; Intervention Studies; Investigation; Malignant Neoplasms; Malignant neoplasm of lung; Marketing; Measures; Mentors; Mentorship; Metabolism; National Comprehensive Cancer Network; National Institute of Drug Abuse; Observational Study; Ohio; Operative Surgical Procedures; Outcome; Patient Recruitments; Patients; Performance Status; Perioperative complication; Persons; Pilot Projects; Policies; Population; Positioning Attribute; Principal Investigator; Professional Organizations; Prospective cohort; Public Health; Quality of life; Randomized; Randomized Clinical Trials; Recommendation; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Safety; Sales; Science; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Standardization; Surgeon; Surgical complication; Symptoms; Tobacco; Tobacco use; Toxic effect; Training; Treatment-related toxicity; United States; United States Food and Drug Administration; Universities; authority; cancer epidemiology; cancer survival; career development; chemotherapy; cigarette smoking; cohort; college; combustible cigarette; design; editorial; electronic cigarette use; evidence base; experience; exposure to cigarette smoke; follow-up; hospital utilization; member; nicotine replacement; patient population; professor; randomized trial; skills; smoking cessation; sound; standard of care; symptomatology; tobacco control; tobacco regulatory science; tool; treatment as usual; treatment guidelines; uptake; week trial

PROJECT SUMMARY/ABSTRACT The overall goal of this proposal is to facilitate Dr. Theodore Brasky’s development into an established and independent investigator for tobacco control. For this research, he will focus on cancer patients and the impact of electronic cigarettes (e-cigs) on cigarette smoking, quitting, and health outcomes. It is established that cigarette smoking adversely affects the cancer patient in many ways. E-cigs have the potential to reduce cigarette smoke exposures, related toxicities, and foster smoking cessation. However, almost no research exists to substantiate this hypothesis. Dr. Brasky is a cancer epidemiologist and member of the Ohio State University Comprehensive Cancer Center (OSUCCC) with considerable expertise in the analysis and interpretation of longitudinal data. Due to a strong institutional environment, he has been participating in various tobacco-focused research projects over the past 2 years. Excited by this, he wants to take advantage of the extraordinary opportunities in tobacco control related to e-cigs. The proposed training plan will enable him to obtain expertise and experience in tobacco research (e.g., coursework in tobacco regulatory science), intervention studies (e.g., coursework in clinical research methods and translational behavioral research), and primary data collection in complementary studies. This training will capitalize on the exceptional institutional environment at OSU and a mentoring team of experts in tobacco control led by Dr. Peter Shields, Deputy Director of the OSUCCC, and Dr. Mary Ellen Wewers, Professor of Health Behavior and Health Promotion at the OSU College of Public Health. Dr. Shields and Dr. Wewers are Multiple Principal Investigators of OSU’s NCI-funded P50 Tobacco Center of Regulatory Science. Herein, Dr. Brasky will address critical research gaps that will aid in the understanding for the impact of e-cigs on the cancer patient generally, and specifically for the creation of sound policy decisions by the Food and Drug Administration. This application will address the smoking lung cancer patient who will be assessed for cigarette and e-cig use in relation to uptake, smoking reduction, quitting, quality of life, and treatment toxicities. The Specific Aims are: 1) to establish an observational cohort of 300 lung cancer patients and examine the associations of e-cigs with smoking reduction, smoking cessation, quality of life, and treatment toxicities; and 2) to establish a pilot randomized trial of a newly-developed research e-cig versus nicotine replacement therapy (standard of care) in 30 stage I-IIIA lung cancer patients planning to undergo surgical resection in order to foster adherence to recommendations and reduce surgical complications. This pilot study will leverage newly-implemented National Cancer Center Network guidelines for smoking cessation at the OSUCCC, and a new e-cig research device provided by the National Institute on Drug Abuse. These complementary experimental and ‘real world’ observational studies will be the first to examine associations in lung cancer patients and will share assessment measures. Results from this research will yield critical data in order to provide sound and evidence-based decisions on e-cigs.

项目总结/摘要 该提案的总体目标是促进西奥多布拉斯基博士发展成为一个既定的， 烟草控制独立调查员。对于这项研究，他将重点放在癌症患者和影响 电子烟（电子烟）对吸烟，戒烟和健康结果的影响。经确定 吸烟在许多方面对癌症患者产生不利影响。电子烟有可能减少 吸烟暴露、相关毒性和促进戒烟。然而，几乎没有研究 是为了证实这一假设Brasky博士是一位癌症流行病学家，也是俄亥俄州的成员 大学综合癌症中心（OSUCCC）在分析和治疗方面具有相当的专业知识， 纵向数据的解释。由于强大的制度环境，他一直参与 在过去的两年里，各种烟草研究项目。兴奋之余，他想趁机 电子烟在烟草控制方面的非凡机遇。拟议的培训计划将使 他获得烟草研究方面的专业知识和经验（例如，烟草管制科学课程）， 干预研究（例如，临床研究方法和转化行为研究课程），以及 补充研究中的主要数据收集。这项培训将利用特殊的机构 俄勒冈州立大学的环境和由副校长Peter Shields博士领导的烟草控制专家指导小组 OSUCCC主任和玛丽埃伦韦尔斯博士，健康行为和健康促进教授， 俄勒冈州立大学公共卫生学院Shields博士和Wewers博士是OSU的多个主要研究者 NCI资助的P50烟草监管科学中心在此，Brasky博士将解决关键的研究差距 这将有助于理解电子烟对癌症患者的影响，特别是对癌症患者的影响。 由食品和药物管理局制定合理的政策决定。此应用程序将解决 吸烟肺癌患者，将评估吸烟和电子烟使用与摄取、吸烟 减少、戒烟、生活质量和治疗毒性。具体目标是：1）建立一个 300名肺癌患者的观察队列，并检查电子烟与吸烟的关系 减少，戒烟，生活质量和治疗毒性;和2）建立一个试点随机试验 在30例I-IIIA期患者中，新开发的研究电子烟与尼古丁替代疗法（标准治疗）的比较 计划接受手术切除以促进遵守建议的肺癌患者 并减少手术并发症。这项试点研究将利用新实施的国家癌症中心 OSUCCC的戒烟网络指南，以及由OSUCCC提供的新电子烟研究设备。 国家药物滥用研究所。这些互补的实验和“真实的世界”观察研究 将是第一个检查肺癌患者中的关联并将分享评估措施的机构。结果 这项研究将产生关键数据，以便就电子香烟问题作出可靠和循证的决定。