Antemortem White Matter Integrity Quantification from DTI and Relationship with Postmortem TDP-43
DTI 死前白质完整性定量及其与死后 TDP-43 的关系
基本信息
- 批准号:10767777
- 负责人:
- 金额:$ 4.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAlzheimer&aposs DiseaseAmygdaloid structureAmyloidAnisotropyAreaAutopsyAxonBiological MarkersBrainBrain regionCerebrovascular DisordersCharacteristicsCognitionCognitiveCohort StudiesCommunicationCommunitiesComputing MethodologiesDataDementiaDimensionsDiseaseDisease ProgressionDistalElderlyFiberFrontotemporal Lobar DegenerationsGoalsHeterogeneityHippocampusImpaired cognitionInternal CapsuleLengthLewy body pathologyLocationLongitudinal cohort studyMeasuresMediatingMediationMethodsNerve DegenerationNeuroanatomyNeurobehavioral ManifestationsNeurobiologyNeurodegenerative DisordersNeuronsPathogenesisPathologicPathologyPatternPersonsPontine structurePopulationProcessResearchResearch PersonnelRoleSamplingShapesStereotypingStructureSyndromeTherapeutic AgentsVariantbrain behaviorburden of illnessentorhinal cortexglobal healthimprovedin vivoneuroimagingneuropathologypotential biomarkerprotein TDP-43tau Proteinswhite matter
项目摘要
Project Summary/Abstract
Dementia syndromes are global health concerns affecting more than 55 million people worldwide, with an
estimated 10 million new cases each year. Without a cure or therapeutic agents to stop the progression of
disease, dementia remains a devastating illness which requires significant exploration. White matter
microstructure is significantly affected within dementia, however, the relationship between underlying disease
and microstructural integrity is poorly understood. Indeed, understanding neurobiological basis underlying
cognitive decline in neurodegenerative disease remains an unmet challenge. There is a dearth of research on
the relationship between antemortem brain characteristics and postmortem disease burden. TAR DNA-binding
protein 43 (TDP-43) proteinopathy is a common feature of many neurodegenerative diseases, is known to affect
white matter structural integrity, and needs to be explored in-vivo. While in addition to neuronal pathology, TDP-
43 is also highly involved in white matter and therefore, studying the relationships between TDP-43 and white
matter structural integrity can allow for a better understanding of the neurodegenerative process. Utilizing a
community-based sample of older adults from two cohort studies from the Rush Alzheimer’s Disease Center, I
plan to measure the relationship between postmortem TDP-43 pathology and spatial antemortem white matter
structural integrity and additionally explore its effect on cognition. Traditional measures of white matter integrity
assume the entire tract to maintain similar characteristics, however, advanced computational research has
identified that white matter integrity varies in stereotyped patterns along the tract. By studying the relationship
between postmortem TDP-43 burden and spatial patterns of antemortem white matter integrity, we can assess
localized white matter integrity as it relates to disease burden. I will then explore the association of white matter
integrity and cognition through correlation and mediation analysis. No previous research has utilized postmortem
neuropathological burden quantification to measure disease effects on in-vivo spatial white matter integrity. By
exploring the relationship of postmortem quantification of TDP-43 burden and antemortem white matter structural
integrity, we may enhance our understanding of the role of disease within the neurodegenerative process. Future
research can expand this research to be used as a potential noninvasive, readily available, antemortem
biomarker indicative of postmortem disease.
项目总结/文摘
项目成果
期刊论文数量(0)
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Ashley Heywood其他文献
Ashley Heywood的其他文献
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{{ truncateString('Ashley Heywood', 18)}}的其他基金
Antemortem White Matter Integrity Quantification from DTI and Relationship with Postmortem TDP-43
DTI 死前白质完整性定量及其与死后 TDP-43 的关系
- 批准号:
10537812 - 财政年份:2022
- 资助金额:
$ 4.39万 - 项目类别: