Pancreatic Cancer-Associated Fibroblasts: Function, Detection, and Regulation

胰腺癌相关成纤维细胞:功能、检测和调节

基本信息

  • 批准号:
    10767490
  • 负责人:
  • 金额:
    $ 25.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-01 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Pancreatic Cancer (PC) survival rates are very low and even lower for patients from low socioeconomic backgrounds/circumstances (SES), often living in geographic locations with limited access to care. One explanation for this disparity could be chronic stress. Several researchers, including our Collaborative Investigator, have shown that Black individuals and those living in neighborhoods with low SES endure sustained exposure to stressful circumstances (e.g. systemic racism, lack of resources), which impact mental health (e.g. anxiety, fear) and augment PC. Neighborhood SES (nSES) hence serve as a macro-environmental indicator of chronic stress, independent of a patient’s SES and mental health. Low nSES, can for example prevent cancer cell death and promote its aggressiveness. If the biologic basis of PC health disparities is to be elucidated, studies proposing to understand how, for example, nSES impacts PC are needed. The parent grant focuses on studying the non-cancerous cells and natural scaffold units of the pancreas in PC. Of note, the specific molecules studied are implicated in chronic stress. In fact, some chronic stress features, such as glutamate excess, are simulated by the non-cancerous units of the pancreas during PC. We reported that pro-tumorigenic activation of these units are indicative of unfavorable PC patient outcomes. Interestingly the same units also are implicated in synapse stability in brain and in the generation of small membranous vesicles that are produced by these units and can be detected in blood. Building on this, our parent grant proposes to: i) reveal how the natural scaffold of these units regulates pro tumoral unit functions; ii) assess whether detection of the unique unit-generated membranous vesicles inform on the pancreatic tumor-promoting vs. tumor-suppressing, status of PC patient’s organ; and iii) question if the molecules relevant for driving pro-tumoral function of the units can be targeted. Here we plan to expand this scope by forging a multidisciplinary partnership with a disparity research expert Dr. Shannon Lynch in the form of 3 specific new aims: Aim 1: Measure biomarkers (high Glu, & others) and macro-environmental measures of chronic stress (nSES; racial segregation) to determine if high levels of environmental stress correlate with biologic stress. Aim 2: Evaluate the correlation between chronic stress measures (biomarkers, macro-environmental measures) and pro-tumoral circulating biomarkers in vesicles informing on local stress-like microenvironments. Aim 3: Determine if microenvironment-indicative biomarkers are associated with PC patient survival time, alone and after adjustment for comprehensive chronic stress measures and race/ethnicity in multivariable regression models.
项目摘要/摘要 胰腺癌(PC)的生存率非常低,对于来自低社会经济背景的患者来说,甚至更低 背景/环境(SES),通常生活在地理位置上,获得护理的机会有限。一 造成这种差异的原因可能是长期的压力。几位研究人员,包括我们的协作 调查表明,黑人个人和那些生活在低SES社区的人 暴露在有压力的环境中(例如系统性种族主义、缺乏资源),这会影响心理健康(例如: 焦虑、恐惧)和增强PC。因此,邻里社会经济状况(NSE)可作为 慢性压力,与患者的自尊和心理健康无关。例如,低NSE可以预防癌症 细胞死亡,并促进其侵略性。如果要阐明PC健康差异的生物学基础, 例如,建议理解NSE如何影响PC的研究是必要的。家长助学金的重点是 对PC中胰腺的非癌细胞和天然支架单位进行研究。值得注意的是,特定的分子 被研究的人与慢性压力有关。事实上,一些慢性应激特征,如谷氨酸过量,是 在PC期间由胰腺的非肿瘤单位模拟。我们报告了促肿瘤激活 这些单位中的每一个都预示着PC患者的不良结局。有趣的是,同样的单位也牵涉其中 在脑中突触的稳定性以及由这些单位产生的小膜泡的产生中 并且可以在血液中检测到。在此基础上,我们的母公司赠款建议:i)揭示 这些单位调节亲肿瘤单位的功能;ii)评估独特单位的检测是否产生 膜泡对胰腺癌患者胰腺促癌与抑瘤状态的影响 器官;以及iii)质疑与驱动这些单位的亲肿瘤功能相关的分子是否可以成为靶点。 在这里,我们计划通过与差异研究专家Dr. 香农·林奇以3个具体新目标的形式: 目的1:测量生物标记物(高谷氨酸等)和慢性应激的宏观环境指标(NSE; 种族隔离),以确定高水平的环境压力是否与生物压力相关。 目标2:评估慢性压力测量(生物标记物、宏观环境)之间的相关性 措施)和囊泡中的亲肿瘤循环生物标记物,告知局部应激样微环境。 目的3:确定指示微环境的生物标志物是否与PC患者的生存时间有关, 在多变量中单独和在调整综合慢性应激措施和种族/民族之后 回归模型。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Edna Cukierman其他文献

Edna Cukierman的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Edna Cukierman', 18)}}的其他基金

Neutralizing Stromal NetrinG1 to Intercept Pancreatic Cancer
中和基质 NetrinG1 以阻止胰腺癌
  • 批准号:
    10505615
  • 财政年份:
    2022
  • 资助金额:
    $ 25.5万
  • 项目类别:
Pancreatic cancer-associated fibroblasts: function, detection, and regulation
胰腺癌相关成纤维细胞:功能、检测和调节
  • 批准号:
    10418178
  • 财政年份:
    2022
  • 资助金额:
    $ 25.5万
  • 项目类别:
Pancreatic cancer-associated fibroblasts: function, detection, and regulation
胰腺癌相关成纤维细胞:功能、检测和调节
  • 批准号:
    10625325
  • 财政年份:
    2022
  • 资助金额:
    $ 25.5万
  • 项目类别:
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
黑色素瘤转移和治疗耐药性的综合方法:ECM 和皮肤生物力学与年龄相关变化的影响
  • 批准号:
    10380313
  • 财政年份:
    2021
  • 资助金额:
    $ 25.5万
  • 项目类别:
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
黑色素瘤转移和治疗耐药性的综合方法:ECM 和皮肤生物力学与年龄相关变化的影响
  • 批准号:
    10333395
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
黑色素瘤转移和治疗耐药性的综合方法:ECM 和皮肤生物力学与年龄相关变化的影响
  • 批准号:
    10158458
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
黑色素瘤转移和治疗耐药性的综合方法:ECM 和皮肤生物力学与年龄相关变化的影响
  • 批准号:
    10574507
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
黑色素瘤转移和治疗耐药性的综合方法:ECM 和皮肤生物力学与年龄相关变化的影响
  • 批准号:
    10524121
  • 财政年份:
    2019
  • 资助金额:
    $ 25.5万
  • 项目类别:
3D-adhesion stromagenesis in cancer permissiveness
癌症许可性中的 3D 粘附基质发生
  • 批准号:
    7142995
  • 财政年份:
    2006
  • 资助金额:
    $ 25.5万
  • 项目类别:
3D-Adhesion Stromagenesis in Cancer Permissiveness
癌症宽容度中的 3D 粘附基质发生
  • 批准号:
    8292558
  • 财政年份:
    2006
  • 资助金额:
    $ 25.5万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 25.5万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了