Mentoring alcohol use intervention research in HIV health care settings

项目摘要/摘要 不健康的饮酒在艾滋病毒/艾滋病的风险和恶化中起着重要作用。有迫切的需要 实施有效的酒精干预策略，培训新的研究人员，减少持续健康 为了结束艾滋病毒的流行，各国之间的差距很大。为了解决这些关键问题，此K24续订申请 建议延长德里克·萨特雷教授的以患者为中心的研究(POR)指导计划 加州大学旧金山分校(UCSF)精神病学和行为科学系，以及 凯撒永久北加州研究部(DOR)兼职研究员。萨特雷医生的 研究方案侧重于艾滋病毒护理背景下的酒精干预，包括严重的 其他物质使用、精神健康问题和医疗条件等并存。在目前的K24 周期，萨特博士已经达到并超过了奖项的目标，并取得了很高的成果：他已经发表了75篇 论文(36篇，第一作者为被辅导者)，在基于健康的艾滋病毒和酒精研究方面获得了两个R01 系统。他的学员主要是临床医生，他们在研究生涯中非常成功， 包括萨特雷博士作为主要导师的两个K奖，以及许多其他导师已经获得了NIH的赠款 和教职员工的职位。这一更新将增强萨特博士开发和实施有效酒精的能力 对艾滋病毒携带者的干预，特别是对种族/族裔少数群体的干预，他们的比例不成比例 受到了影响。他的指导将继续以酒精和艾滋病毒健康环境和出色的培训为基础 程序。在这次更新中，他建议开发一个创新的酒精POR指导计划 加州大学旧金山分校艾滋病预防研究中心(CAPS)访问教授计划，以促进 少数族裔初级科学家的代表性不足。学员将利用Dr的基础设施和资源。 萨特正在进行的研究，包括大量的酒精和艾滋病毒数据集和多学科研究 合作者。萨特雷博士建议通过接受以下培训来进一步加强他的临床POR指导 实施科学和健康的社会决定因素。拟议的研究将与 导师将他最近资助的R01扩展到检查酒精风险概况、获得酒精治疗和艾滋病毒 临床结果，为酒精干预的实施提供信息。总而言之，此次K24续订将利用 萨特雷博士的研究指导计划，在加州大学旧金山分校和国防部拥有广泛的基础设施，以支持一个计划 在酒精和艾滋病毒干预研究中扩大POR辅导，以推进实施目标 减少威斯康星医院酒精相关问题的有效干预措施。

Project Summary/Abstract Unhealthy alcohol use plays a major role in risk for and exacerbation of HIV/AIDS. There is an urgent need to implement effective alcohol intervention strategies, train new researchers, and reduce ongoing health disparities in order to end the HIV epidemic. Addressing these critical issues, this K24 renewal application proposes to extend the mentoring program in patient-oriented research (POR) of Dr. Derek Satre, Professor in the University of California, San Francisco (UCSF), Department of Psychiatry and Behavioral Sciences, and Adjunct Investigator in the Kaiser Permanente Northern California Division of Research (DOR). Dr. Satre’s research program is focused on alcohol interventions in the context of HIV care, including serious comorbidities such other substance use, mental health problems, and medical conditions. In the current K24 cycle, Dr. Satre has met and exceeded the aims of the award and been highly productive: he has published 75 papers (36 with mentees as first author) and obtained two R01s in HIV and alcohol research based in health systems. His mentees are primarily clinicians and they have been very successful in their research careers, including two K awards with Dr. Satre as primary mentor, and many other mentees have received NIH grants and faculty positions. This renewal will enhance Dr. Satre’s ability to develop, and implement effective alcohol interventions with people with HIV (PWH) especially racial/ethnic minorities, who are disproportionately impacted. His mentoring will continue to be based in alcohol and HIV health settings and outstanding training programs. New in this renewal, he proposes to develop an innovative alcohol POR mentoring program within the UCSF Center for AIDS Prevention Studies (CAPS) Visiting Professor Program, to enhance the careers of underrepresented minority junior scientists. Mentees will leverage the infrastructure and resources of Dr. Satre’s ongoing studies, which include large alcohol and HIV data sets and multidisciplinary research collaborators. Dr. Satre proposes to further enhance his clinical POR mentoring by obtaining training in implementation science and social determinants of health. The proposed research to be conducted with mentees extends his recently funded R01 to examine alcohol risk profiles, access to alcohol treatment and HIV clinical outcomes, to inform alcohol intervention implementation. In summary, this K24 renewal will leverage Dr. Satre’s research mentoring program with extensive infrastructure at UCSF and DOR to support a program of expanded POR mentoring in alcohol and HIV intervention research, to advance the goal of implementing effective interventions to reduce alcohol-related problems for PWH.