Role of KCNQ2 Channels in Control of Breathing
Role of KCNQ2 Channels in Control of Breathing
批准号:
10771781
负责人:
DANIEL K MULKEY
金额:
$4.62万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-01-01 至 2026-01-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
SUMMARY
DevelopmaenndetpaillepntciecphalaospsaotchiwyaittKehCdNQc2hannhealsbseepnrimalriinlktyeod
loss-of-KfCuNnQcm2tuitoantiHoonwse.vaenri,ncreansuimnbgoefrrecurKrCeNnQtg2ain-of-fun
vari(ain.tRes2.0C,1)havbeeeindentPiaftiiewedin.thshKeCNQR221oc mutatdiiosnpsleavyemryeoclonu
andearplryofohuynpdoventdiuletaorteidounccehdemoreCfulrerxe.mnetclhya,nibsywmhsicKhCNQ2
channceolnsttrhdoerlitvobereaatrhueencleTahrer.etrotrnaupcelz(eoRuiTsdiNsa)nimporrteasnptirat
centneeru;rointshriesgifounncatsiroenspircahteomroyrecbeyprteogruslatinginrespotnose
breathin
changientsisCsOu2.eChemosenRsTiNnteiuvreaornaesctivbayatniendcreianCsO2/eH+,whereagaasin
of-funKctniqmo2untatmiioghnhytperpoRlTaNnreiuzreaonmdsakiemtordeiffitcoruelstptoonCdO2/H+.
Indeweodr,fkrotmhpearegnrtasnhtowtehdeaxtpresosftihroeencurKrcennqmt2utatKiconnRq221ocinRTN
neurbolnusntthevedentirleastpoortnyoCsOe2.Excitwienagllsfyoo,utnhdaKtcnqc2hanancetliivnRiTtNy
neuroinsrsegulbaytaed+-Hmyo-Incoos!irtaonls(pHoMrItwTeh)ricihmpomrytos-intososiutpoplort
producotfpihoonsphatid4y,l5i-nboissipth(ooPls2I)pP,ahnaatlelosatcetriivocafKtconrqc2hannHeMlIsT.
expresisntihoRenTNregiiosrnestroinclttyoecdhemosennseiutrioTvnhese.refwoehryep,othtehsaitze
HMIiTsrequfiorKrecdnqc2hanancetliivnRiTtNnyeuroInnpsa.rtiwceuplraorp,tohsHae+t-depenmdyeont
inostirtaonlsipnotRroTtNneurobnyHsMIwTiilnlcrePaI2sPleevaenldsactiKvcantqec2hannteollismit
CO2/H+-stimualcattiaevdsiwteyla,lstomaintnaeiunrmaoldulabtynieounrotrantshmasititgttneharrlsough
Gq-courpelceedpatnodPrIs2PhydrolTyhsutishs,oe.bjecotftihvaiepspliciasttodieotnertmhieenxetetnot
whiKcchnqc2hannaenlHdsMIiTntetrocaocnttRrToNclhemorecuenpdtneiorornmcaolndiatniwdohnesther
HMIcTabnetargettoiemdprborveatihnmiincgtehaetxprKecsnsRq22o1.cThethrSepeecAiifmioscfthis
projaerce1t:)detertmhieenxetetnowthiHcMhIiTnfluKecnncqec2shanrnegluloaftcihoenmosensit
RTNneuro2n)dse;tercmoinnteriboufKtcinoqcn2hsannaenldHsMIiTnteratcoRtTiNocnhsemorecep
netweoxrckitaabnid3l)tioetsyt;abHlMiIsiThnRTNneuroansastherapteaurtfgioeKcrtcnqa2ssociat
breatahbinnogrmaTlhiertaiteisof.notarhlrieesseairstchhabtyundersthaonwHdMiInrTgegulKactneqs2
chanancetliivnRiTtNyneurownecsa,lnaayfoundaftodireovnelotprienagtmfeornretsspirpartoobrlyems
associwaitKehcdnqm2utations.
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海外基金