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Role of KCNQ2 Channels in Control of Breathing

Role of KCNQ2 Channels in Control of Breathing
KCNQ2 通道在呼吸控制中的作用
批准号:
10771781
负责人:
DANIEL K MULKEY
金额:
$4.62万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-01-01 至 2026-01-31

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SUMMARY DevelopmaenndetpaillepntciecphalaospsaotchiwyaittKehCdNQc2hannhealsbseepnrimalriinlktyeod loss-of-KfCuNnQcm2tuitoantiHoonwse.vaenri,ncreansuimnbgoefrrecurKrCeNnQtg2ain-of-fun vari(ain.tRes2.0C,1)havbeeeindentPiaftiiewedin.thshKeCNQR221oc mutatdiiosnpsleavyemryeoclonu andearplryofohuynpdoventdiuletaorteidounccehdemoreCfulrerxe.mnetclhya,nibsywmhsicKhCNQ2 channceolnsttrhdoerlitvobereaatrhueencleTahrer.etrotrnaupcelz(eoRuiTsdiNsa)nimporrteasnptirat centneeru;rointshriesgifounncatsiroenspircahteomroyrecbeyprteogruslatinginrespotnose breathin changientsisCsOu2.eChemosenRsTiNnteiuvreaornaesctivbayatniendcreianCsO2/eH+,whereagaasin­ of-funKctniqmo2untatmiioghnhytperpoRlTaNnreiuzreaonmdsakiemtordeiffitcoruelstptoonCdO2/H+. Indeweodr,fkrotmhpearegnrtasnhtowtehdeaxtpresosftihroeencurKrcennqmt2utatKiconnRq221ocinRTN neurbolnusntthevedentirleastpoortnyoCsOe2.Excitwienagllsfyoo,utnhdaKtcnqc2hanancetliivnRiTtNy neuroinsrsegulbaytaed+-Hmyo-Incoos!irtaonls(pHoMrItwTeh)ricihmpomrytos-intososiutpoplort producotfpihoonsphatid4y,l5i-nboissipth(ooPls2I)pP,ahnaatlelosatcetriivocafKtconrqc2hannHeMlIsT. expresisntihoRenTNregiiosrnestroinclttyoecdhemosennseiutrioTvnhese.refwoehryep,othtehsaitze HMIiTsrequfiorKrecdnqc2hanancetliivnRiTtNnyeuroInnpsa.rtiwceuplraorp,tohsHae+t-depenmdyeon­t inostirtaonlsipnotRroTtNneurobnyHsMIwTiilnlcrePaI2sPleevaenldsactiKvcantqec2hannteollismit CO2/H+-stimualcattiaevdsiwteyla,lstomaintnaeiunrmaoldulabtynieounrotrantshmasititgttneharrlsough Gq-courpelceedpatnodPrIs2PhydrolTyhsutishs,oe.bjecotftihvaiepspliciasttodieotnertmhieenxetetnot whiKcchnqc2hannaenlHdsMIiTntetrocaocnttRrToNclhemorecuenpdtneiorornmcaolndiatniwdohnesther HMIcTabnetargettoiemdprborveatihnmiincgtehaetxprKecsnsRq22o1.cThethrSepeecAiifmioscfthis projaerce1t:)detertmhieenxetetnowthiHcMhIiTnfluKecnncqec2shanrnegluloaftcihoenmosensit RTNneuro2n)dse;tercmoinnteriboufKtcinoqcn2hsannaenldHsMIiTnteratcoRtTiNocnhsemorecep netweoxrckitaabnid3l)tioetsyt;abHlMiIsiThnRTNneuroansastherapteaurtfgioeKcrtcnqa2ssociat breatahbinnogrmaTlhiertaiteisof.notarhlrieesseairstchhabtyundersthaonwHdMiInrTgegulKactneqs2 chanancetliivnRiTtNyneurownecsa,lnaayfoundaftodireovnelotprienagtmfeornretsspirpartoobrlyems associwaitKehcdnqm2utations.
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Molecular signature of parafacial expiratory neurons
  • 批准号:
    10750185
  • 项目类别:
  • 资助金额:
    $44.28万
  • 财政年份:
    2023
  • 负责人:
    DANIEL K MULKEY
  • 依托单位:
Defining Astrocyte Heterogenity Across the Brainstem Respiratory Circuit
  • 批准号:
    9896328
  • 项目类别:
  • 资助金额:
    $24.15万
  • 财政年份:
    2019
  • 负责人:
    DANIEL K MULKEY
  • 依托单位:
Defining Astrocyte Heterogenity Across the Brainstem Respiratory Circuit
  • 批准号:
    10019601
  • 项目类别:
  • 资助金额:
    $20.13万
  • 财政年份:
    2019
  • 负责人:
    DANIEL K MULKEY
  • 依托单位:
Role of KCNQ2 Channels in Control of Breathing
  • 批准号:
    10467261
  • 项目类别:
  • 资助金额:
    $51.82万
  • 财政年份:
    2018
  • 负责人:
    DANIEL K MULKEY
  • 依托单位:
海外基金