Spinal Cord Injury and Heat Acclimation

脊髓损伤和热适应

• 批准号: 7408853
• 负责人: Jonathan Wingo
• 金额: $ 4.68万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7408853
• 关键词: Acclimatization; Accounting; Activities of Daily Living; Address; Affect; Blood Plasma Volume; Blood flow; Body Temperature; Cardiovascular system; Cessation of life; Climate; Condition; Coronary heart disease; Cross-Sectional Studies; Cutaneous; Daily; Data; Doctor of Philosophy; Environment; Exercise; Functional disorder; Goals; Heart Diseases; Heart Rate; Heat Stress Disorders; Heat Stroke; Heating; Immersion Investigative Technique; Impairment; Individual; Injury; Insulin Resistance; Lesion; Life Style; Literature; Longitudinal Studies; Microdialysis; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Performance; Persons; Physical Capacity; Physical activity; Physiologic Thermoregulation; Population; Protocols documentation; Rate; Risk; Sample Size; Severities; Skin; Spinal Cord Lesions; Spinal cord injury; Stimulus; Stress; Stroke Volume; Sweat; Sweating; Syncope; Techniques; Temperature; Testing; Travel; United States; Vasomotor; Water; Work; base; cardiovascular disorder risk; coping; day; exhaustion; experience; fitness; improved; novel; response

DESCRIPTION (provided by applicant): Impaired thermoregulation in individuals with a spinal cord lesion can result in elevated cardiovascular and thermal strain during exercise, which may discourage these individuals from participating in regular physical activity, especially that occurring in a warm environment. Physical inactivity increases the risk of developing several morbidities, including coronary heart disease, Type II diabetes, and obesity. Heat acclimation may improve thermal tolerance of spinal cord injured (SCI) individuals, thereby enabling greater comfort during exercise and day-to-day heat stresses, such as outdoor exposures during summer months. The main objective of the proposed project is to test the hypothesis that the degree of thermal impairment in individuals with SCI will be related to the level of the injury and that individuals with SCI can counteract impaired thermoregulation by acclimating to a hot environment. Specific aim 1: Test the hypothesis that in individuals with a spinal cord lesion, the severity of vasomotor and sudomotor function impairments is related to lesion level. Specific aim 2: Test the hypothesis that individuals with SCI can counteract impaired thermoregulation by acclimating to a hot environment, which will 1) improve sweating and skin blood flow, 2) result in lower core body temperature during a given thermal challenge, 3) and result in lower cardiovascular strain (lower heart rate and higher stroke volume) during exercise. Specific aim 1 will be accomplished by conducting a cross-sectional study of differences in thermal and cardiovascular responses between individuals with high and individuals with low spinal cord lesions, as well as able-bodied individuals. Novel techniques will be used to assess expected differences and associated mechanisms. Specific aim 2 will be accomplished by conducting a longitudinal study of the effects and mechanisms of heat acclimation in individuals with SCI.

描述（由申请人提供）：患有脊髓病变的个体的体温调节受损会导致运动过程中的心血管和热应变升高，这可能会阻止这些人参加常规身体活动，尤其是在温暖的环境中发生的情况。身体上的不活跃增加了发展多种病毒性的风险，包括冠状动脉疾病，II型糖尿病和肥胖症。热适应可能会提高脊髓受伤（SCI）个体的热耐受性，从而在运动和日常的热应力（例如夏季的室外暴露）期间带来更大的舒适性。拟议项目的主要目的是检验以下假设：SCI患者的热损伤程度与损伤水平有关，SCI患者可以通过适应热环境来抵消受损受损调节。具体目的1：检验以下假设：在患有脊髓病变的个体中，血管舒缩和Sudomotor功能障碍的严重程度与病变水平有关。具体目的2：检验以下假设：SCI患者可以通过适应热环境来抵消受损受损的温度调节，这将改善出汗和皮肤血流，2）在给定的热挑战期间导致较低的核心体温，3），并导致较低的心血管菌株（运动过程中较低的心率和较低的训练）。特定的目标1将通过对患有脊髓病变低的人以及身体健康的个体之间的热血和心血管反应的差异进行横断面研究来实现。新技术将用于评估预期差异和相关机制。具体目标2将通过对SCI个体的热适应的效果和机制进行纵向研究来实现。