MOUSE MODELS FOR NEURAL TUBE DEFECTS

神经管缺陷的小鼠模型

• 批准号: 7577954
• 金额: $ 9.88万
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7577954
• 关键词: MOUSE; MODELS; NEURAL; TUBE; DEFECTS

Structural birth defects are the leading cause of infant mortality in the US and have an enormous physical and emotional public heath impact. Understanding their etiology requires thorough knowledge of the basic underlying mechanisms associated with the development of organ systems, including the central nervous system. Basic research using animal models is uncovering the factors that trigger and control developmental processes. Neural tube defects (NTDs), which include spina bifida and anencephaly, are one of the most frequent and severe developmental anomalies of the central nervous system. This contract supports mouse models of neural tube defects. It was originally issued in 1989 to establish a centralized, national resource. By supporting this resource, scientists interested in studying this important abnormality have ready access to these unique research animals. Currently, the primary objectives of this contract are to 1) maintain mouse strains with neural tube defects, 2) distribute breeding pairs of mice from these strains on request to investigators in the scientific community and 3) develop and evaluate potential new mouse models.

结构性出生缺陷是美国婴儿死亡的主要原因，并对公众的身体和情感健康产生巨大影响。了解其病因学需要彻底了解与器官系统（包括中枢神经系统）发育相关的基本潜在机制。使用动物模型的基础研究正在揭示触发和控制发育过程的因素。 神经管缺陷（NTDs），包括脊柱裂和无脑畸形，是中枢神经系统最常见和最严重的发育异常之一。该合同支持神经管缺陷的小鼠模型。它最初是在1989年发布的，目的是建立一个集中的国家资源。通过支持这一资源，有兴趣研究这一重要异常的科学家可以随时访问这些独特的研究动物。目前，该合同的主要目标是：1）维持具有神经管缺陷的小鼠品系，2）根据科学界研究人员的要求，从这些品系中分配育种小鼠对，3）开发和评估潜在的新小鼠模型。