Small Imaging Core

小型成像核心

• 批准号: 7935240
• 负责人: Joel Richard Garbow
• 金额: $ 0.81万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7935240
• 关键词: Academic Medical Centers; Animals; Arts; Biological Models; Bioluminescence; Biometry; Cancer Model; Catheters; Communities; Consultations; Contrast Media; Custom; Data; Data Analyses; Development; Engineering; Fluorescence; Funding; Heart; Image; Image Analysis; Imagery; Imaging technology; Informatics; Institution; Laboratory Animal Models; Laboratory Animals; Magnetic Resonance Imaging; Maintenance; Malignant Neoplasms; Microscopy; Mus; Operative Surgical Procedures; Optics; Physics; Physiologic Monitoring; Positron-Emission Tomography; Procedures; Rattus; Research; Research Infrastructure; Research Personnel; Resource Development; Resources; Scientist; Sentinel Lymph Node; Services; System; Technology; Ultrasonography; Universities; Validation; Washington; absorption; design; diffuse optical tomography; frontier; imaging modality; in vivo; instrumentation; member; optical imaging; pre-clinical; programs; research and development; research clinical testing; research study; single photon emission computed tomography

Small Animal Imaging (WUSAIR) Core The Washington University Small Animal Imaging Resource (WUSAIR) is one of the five original Small Animal Imaging Research Program (SAIRP) centers funded in 1999 and was competitively renewed in 2004. WUSAIR provides state-of-the-art facilities and infrastructure for MRI, PET, CT, SPECT and optical imaging of mice, rats and other small laboratory animals. Located in the heart of the Washington University Medical Center, WUSAIR combines instrumental and intellectual capabilities found at few other institutions. WUSAIR serves a broad community of cancer scientists, non-experts in MRI, CT, PET or optical technology, who have a pressing need for quantitative image analysis of small laboratory animal model systems. A particular focus is on mouse and rat models of cancer. WUSAIR also provides research and development at the frontier of imaging technology in an effort to make the most powerful new imaging strategies available to its community of users. WUSAIR imaging modalities are supported by the following operational instrumentation: microPET, microCT, nanoSpect, small animal 4.7 T and 11.74 T MRI, optical absorption, fluorescence, diffuse optical tomography (DOT) and bioluminescence in vivo imaging, and optical microscopy, through both commercial and custom built systems. See resources for a complete listing of instrumentation. The ancillary services and capabilities within WUSAIR include physics and engineering support for the development and design of new hardware and imaging methods; informatics support for local and remote data access, analysis, visualization and archival; new contrast-agent development; biostatistics consultation for experiment planning and data analysis; and animal procedure assistance for surgical procedures, catheter placement and maintenance, and monitoring of physiologic status during imaging experiments. WUSAIR will provide the NTR with comprehensive small-animal imaging resources for development of probes and pre-clinical evaluations and validation of imaging methods. WUSAIR also provides the potential for other members of the NTR-Networks to utilize comprehensive small-animal imaging resources. This will be of particular benefit to institutions lacking in one of the many imaging modalities represented by WUSAIR. Importantly, WUSAIR will help to facilitate new projects quickly and efficiently and thus is compatible with offsite investigators.

小动物成像（WUSAIR）核心 华盛顿大学小动物影像资源（WUSAIR）是五个原始的小动物影像资源之一。 动物成像研究计划（SAIRP）中心于1999年获得资助，并于2004年获得竞争性更新。 WUSAIR为MRI、PET、CT、SPECT和光学成像提供最先进的设备和基础设施， 小鼠、大鼠和其他小型实验动物。位于华盛顿大学医学中心的中心地带， 中心，WUSAIR结合了在其他几个机构发现的工具和智力能力。WUSAIR 服务于广泛的癌症科学家社区，MRI，CT，PET或光学技术的非专家， 迫切需要对小型实验动物模型系统进行定量图像分析。一个特别的重点是 在小鼠和大鼠癌症模型上。WUSAIR还提供前沿的研发， 成像技术，努力使最强大的新的成像策略提供给其社区， 用户. WUSAIR成像模式由以下操作仪器支持：microPET， microCT、nanoSpect、小动物4.7 T和11.74 T MRI、光学吸收、荧光、漫射光学 断层扫描（DOT）和生物发光体内成像，以及光学显微镜，通过这两个商业 和定制系统。参见参考资料以获得完整的仪器清单。辅助服务和 WUSAIR内部的能力包括为新产品的开发和设计提供物理和工程支持 硬件和成像方法;为本地和远程数据访问、分析、可视化提供信息学支持 和存档;新造影剂开发;实验计划和数据的生物统计学咨询 分析;以及外科手术、导管放置和维护的动物手术协助，以及 在成像实验期间监测生理状态。 WUSAIR将为NTR提供全面的小动物成像资源，用于开发 探针和临床前评价以及成像方法的验证。WUSAIR还提供了潜在的 NTR网络的其他成员利用全面的小动物成像资源。这将是 特别有利于缺乏WUSAIR所代表的许多成像模式之一的机构。 重要的是，WUSAIR将有助于快速有效地促进新项目，因此与 场外调查员