Resource Section
资源部分
基本信息
- 批准号:10773479
- 负责人:
- 金额:$ 23.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-12-01 至 2028-11-30
- 项目状态:未结题
- 来源:
- 关键词:AccreditationAddressAdherenceAffectAllelesAnimal ExperimentsAnimal TestingAnimalsArchivesAreaBiohazardous SubstanceBiologicalBreedingCommunicationCommunitiesCryopreservationData AnalysesDisaster PlanningDisastersDiseaseDisease modelEducational MaterialsEmergency SituationEnsureEnvironmentEssential workerEventFamiliarityGenetic DriftGenetic EngineeringGenetic IdentityGenotypeGoalsGuidelinesHealthHeartIACUCInbred Strains MiceInfrastructureInstitutionKnockout MiceLeadershipMaintenanceMedicineMethodsModelingMonitorMusNatural DisastersPhenotypePoliciesProceduresProtocols documentationPublishingReagentRecoveryReporterReproducibilityResearchResearch DesignResourcesRiceSafetySample SizeSiteStandardizationStatistical MethodsTechniquesTechnologyTestingTimeTraining ActivityUnited States National Institutes of HealthWorkanimal resourcecohortcomparativegenome editinggenome integrityinformatics toolinstitutional biosafety committeeinstrumentationmodel organismmouse modeloperationorganizational structureprecision medicinepreclinical studypreservationprogramsquality assurancerepositoryresponsible research conductsafety assessmentsomatic cell gene editingsuccesstool
项目摘要
3. ABSTRACT – RESOURCES SECTION
Poor reproducibility of published research employing model organisms and lack of transparency of study designs
have become areas of concern for the scientific community. These issues can profoundly affect the interpretation
of preclinical studies, including those assessing the safety and efficacy of somatic cell genome editing
technologies and delivery approaches. At the heart of reproducibility issues are the model organism themselves.
Stability and identity of the genetic background, genome integrity, and specifics of genetically engineered alleles
often vary between studies due to use of similar but independently developed models or differences in the quality
of model maintenance. Moreover, variabilities in the quality of study designs used by different groups can
significantly impact study conclusions. Centralization and standardization of high-quality maintenance pipelines
for mouse models can help to addresses issues with study reproducibility and transparency, as exemplified by
the successes of the BCM component of the Knockout Mouse Phenotyping Project, BCM Center for Precision
Medicine Models, and the current BCM-Rice Small Animal Testing Center of the Somatic Cell Genome Editing
program. The Resource Section of the BCM/Rice Genome Editing Testing Center (GETC) will leverage the
approaches, infrastructures, and expertise of our existing mouse modeling programs to (1) establish a
management plan that ensures well-organized Section operations, high-quality animal resources, and timely
project progression, (2) characterize and maintain high-quality mouse resources for testing of delivery reagents
and genome editing tools, (3) preserve, import, and distribute Center mouse resources, (4) evaluate and maintain
adherence to regulatory guidelines and biohazard safety protocols, and (5) implement a disaster plan to minimize
loss and recovery time of resources in the event of a catastrophic disaster.
3.摘要-资源部分
采用模式生物的已发表研究的重现性差,研究设计缺乏透明度
已经成为科学界关注的领域。这些问题可以深刻地影响解释
临床前研究,包括评估体细胞基因组编辑的安全性和有效性的研究
技术和交付方法。可重复性问题的核心是模式生物本身。
遗传背景的稳定性和同一性、基因组完整性和基因工程等位基因的特异性
由于使用相似但独立开发的模型或质量差异,
模型维护。此外,不同群体所使用的研究设计质量的差异可能会导致
对研究结论产生重大影响。优质维修管道集中化、标准化
可以帮助解决研究再现性和透明度的问题,例如
基因敲除小鼠表型分型项目的成功,
医学模型,以及目前的体细胞基因组编辑的BCM-Rice小动物试验中心
程序.水稻基因组编辑测试中心(GETC)的资源部门将利用
方法,基础设施和我们现有的鼠标建模程序的专业知识,以(1)建立一个
管理计划,确保组织良好的部门运作,高质量的动物资源,并及时
项目进展,(2)表征和维护用于交付试剂测试的高质量小鼠资源
和基因组编辑工具,(3)保存,进口和分发中心小鼠资源,(4)评估和维护
遵守监管指南和生物危害安全协议,以及(5)实施灾难计划,以最大限度地减少
在发生灾难性灾难时资源的损失和恢复时间。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Denise Grant Lanza其他文献
Denise Grant Lanza的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
$ 23.33万 - 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
- 批准号:
10738120 - 财政年份:2023
- 资助金额:
$ 23.33万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10526768 - 财政年份:2022
- 资助金额:
$ 23.33万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10701072 - 财政年份:2022
- 资助金额:
$ 23.33万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10679092 - 财政年份:2021
- 资助金额:
$ 23.33万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10432133 - 财政年份:2021
- 资助金额:
$ 23.33万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10327065 - 财政年份:2021
- 资助金额:
$ 23.33万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10377366 - 财政年份:2019
- 资助金额:
$ 23.33万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10574496 - 财政年份:2019
- 资助金额:
$ 23.33万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 23.33万 - 项目类别:














{{item.name}}会员




