Resource Section
资源部分
基本信息
- 批准号:10773479
- 负责人:
- 金额:$ 23.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-12-01 至 2028-11-30
- 项目状态:未结题
- 来源:
- 关键词:AccreditationAddressAdherenceAffectAllelesAnimal ExperimentsAnimal TestingAnimalsArchivesAreaBiohazardous SubstanceBiologicalBreedingCommunicationCommunitiesCryopreservationData AnalysesDisaster PlanningDisastersDiseaseDisease modelEducational MaterialsEmergency SituationEnsureEnvironmentEssential workerEventFamiliarityGenetic DriftGenetic EngineeringGenetic IdentityGenotypeGoalsGuidelinesHealthHeartIACUCInbred Strains MiceInfrastructureInstitutionKnockout MiceLeadershipMaintenanceMedicineMethodsModelingMonitorMusNatural DisastersPhenotypePoliciesProceduresProtocols documentationPublishingReagentRecoveryReporterReproducibilityResearchResearch DesignResourcesRiceSafetySample SizeSiteStandardizationStatistical MethodsTechniquesTechnologyTestingTimeTraining ActivityUnited States National Institutes of HealthWorkanimal resourcecohortcomparativegenome editinggenome integrityinformatics toolinstitutional biosafety committeeinstrumentationmodel organismmouse modeloperationorganizational structureprecision medicinepreclinical studypreservationprogramsquality assurancerepositoryresponsible research conductsafety assessmentsomatic cell gene editingsuccesstool
项目摘要
3. ABSTRACT – RESOURCES SECTION
Poor reproducibility of published research employing model organisms and lack of transparency of study designs
have become areas of concern for the scientific community. These issues can profoundly affect the interpretation
of preclinical studies, including those assessing the safety and efficacy of somatic cell genome editing
technologies and delivery approaches. At the heart of reproducibility issues are the model organism themselves.
Stability and identity of the genetic background, genome integrity, and specifics of genetically engineered alleles
often vary between studies due to use of similar but independently developed models or differences in the quality
of model maintenance. Moreover, variabilities in the quality of study designs used by different groups can
significantly impact study conclusions. Centralization and standardization of high-quality maintenance pipelines
for mouse models can help to addresses issues with study reproducibility and transparency, as exemplified by
the successes of the BCM component of the Knockout Mouse Phenotyping Project, BCM Center for Precision
Medicine Models, and the current BCM-Rice Small Animal Testing Center of the Somatic Cell Genome Editing
program. The Resource Section of the BCM/Rice Genome Editing Testing Center (GETC) will leverage the
approaches, infrastructures, and expertise of our existing mouse modeling programs to (1) establish a
management plan that ensures well-organized Section operations, high-quality animal resources, and timely
project progression, (2) characterize and maintain high-quality mouse resources for testing of delivery reagents
and genome editing tools, (3) preserve, import, and distribute Center mouse resources, (4) evaluate and maintain
adherence to regulatory guidelines and biohazard safety protocols, and (5) implement a disaster plan to minimize
loss and recovery time of resources in the event of a catastrophic disaster.
3.摘要--资源部分
使用模型生物的已发表研究的重复性较差,研究设计缺乏透明度
已经成为科学界关注的领域。这些问题会对解释产生深远的影响。
临床前研究,包括评估体细胞基因组编辑的安全性和有效性的研究
技术和交付方法。可再生性问题的核心是模型生物体本身。
遗传背景、基因组完整性和基因工程等位基因特性的稳定性和同一性
由于使用相似但独立开发的模型或质量差异,研究之间经常存在差异
模型维修部。此外,不同小组使用的研究设计质量的差异可以
显著影响研究结论。高质量维护管道的集中化和标准化
对于老鼠模型,可以帮助解决研究的重复性和透明度问题,例如
BCM精密中心基因敲除小鼠表型项目中BCM组件的成功
医学模型,以及目前BCM-水稻小动物实验中心的体细胞基因组编辑
程序。BCM/水稻基因组编辑测试中心(GETC)的资源科将利用
我们现有的鼠标建模程序的方法、基础设施和专业知识,以(1)建立
确保科室作业井然有序、动物资源优质、及时的管理计划
项目进展,(2)确定和维护用于测试递送试剂的高质量鼠标资源
和基因组编辑工具,(3)保存、导入和分发中心小鼠资源,(4)评估和维护
遵守监管指南和生物危害安全协议,以及(5)实施灾害计划,将
发生灾难性灾难时的资源损失和恢复时间。
项目成果
期刊论文数量(0)
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