A Chicago Biomedical Consortium Hub of Innovative Technologies for Entrepreneurship and Science (CBC - HITES)

项目总结 拥有三所R1大学和多个研究机构的芝加哥大都会统计区充斥着 具有学术创新，但需要吸引更多的早期生物制药专用资本和更多的生物制药 企业家接受培训，将基于大学的项目与技术诀窍和资金联系起来，从而可以发起 生物医学在新兴生态系统中的应用。芝加哥生物医学联盟(CBC)，一个 伊利诺伊大学芝加哥分校(UIC)、伊利诺伊大学 芝加哥大学(UC)和西北大学(NU)成立于2006年，2016年进行了重新设想，并进行了更新 2022年，弥合学术创新者(AcIns)从想法到临床实施的知识差距。LED灯 由西北大学以CBC基础设施为基础，开发了不同的博士培养群体 创业研究员(EFS)，并启用了芝加哥三所主要大学的翻译奖项， 整合来自多校区网络的临床翻译专业知识，并提供此类服务 在芝加哥的九个研究机构中，芝加哥生物医学联盟创新中心 科学中的技术和创业(CBC-Hites)将建立一个规模化的多校园、学术 为想要开发生物制药小分子、生物制剂和新技术的AcIns提供服务中心 诊断/治疗方式(例如细胞和遗传疗法)。 CBC-Hites将为芝加哥的AcIns提供多种服务，从申请请求开始 (RFA)阶段，并在项目执行中达到高潮。在前行业人员和一名 专业的生物制药项目经理，该中心的EFS将把AcIns的想法转化为产业 等级分析和项目计划。分析经过科学和临床验证，并最终通过 最终买家，通过EF/AcIn向合资企业外部审查委员会(VERB)联合演示，以 通知资金来源。CBC-Hites的领导层包括内科/外科科学家和具有 与该市临床和翻译科学奖S、社区医生团体的联系 和医疗保健组织更好地将临床视角与深度发现能力相结合。中心 还将监管和实施科学纳入中心。 由CBC-Hites资助的项目将在需要股权融资之前1-2年与风险投资接洽，并根据 当他们被筛选出来时，没有资金的项目会得到大量的研究和差距分析，这可能是 用于重新提交或替代资金。风险投资与前景看好的AcIns和精心策划的研究有关， 让他们的工作变得更容易。在他们一到两年的培训期间，EFS与大学联网，每所大学 其他，和更广泛的生态系统，然后去芝加哥的创业生态系统工作，拉动更多 这将使大学的学术资产增值，从而最大限度地发挥其培训的效用。故意招募 多元化的EFS群体使一个强大、包容的生物经济能够吸引风投资金和更多人才。

PROJECT SUMMARY With three R1 universities and multiple research institutions, the Chicago Metropolitan Statistical Area is awash with academic innovation but needs to attract more early-stage biopharma specific capital and more “bio- entrepreneurs” trained to link university-based projects to the know-how and funding that can launch a biomedical application into the emerging ecosystem. The Chicago Biomedical Consortium (CBC), a philanthropically funded research consortium between the University of Illinois Chicago (UIC), the University of Chicago (UC), and Northwestern University (NU) was founded in 2006, reimagined in 2016, and renewed in 2022 to bridge the Academic Innovator’s (AcIns) knowledge gap from idea to clinical implementation. Led by Northwestern University, anchored on CBC infrastructure that has developed diverse cohorts of PhD trained Entrepreneurial Fellows (EFs) and enabled translational awards across the three major Chicago universities, incorporating clinical translational expertise from a multi-campus network, and making such services available across nine Chicago research institutions, the Chicago Biomedical Consortium Hub for Innovative Technology and Entrepreneurship in the Sciences (CBC-HITES) will build a scaled multi-campus, academic service center for AcIns who want to develop biopharma small molecules, biologics, and new diagnostic/therapeutic modalities (e.g. cell and genetic therapies). The CBC-HITES will provide Chicago’s AcIns with multiple services, starting with the Request for Applications (RFA) stage and culminating in project execution. Under expert supervision by ex-industry personnel and a professional biopharmaceutical project manager, the center’s EFs will develop the AcIns’ ideas into industry grade analyses and project plans. Analyses are scientifically and clinically validated and, ultimately, validated by the end buyer, through an EF/AcIn joint presentation to a venture External Review Board (venture ERB) to inform funding. CBC – HITES’s leadership includes physician/surgeon scientists and expert drug hunters with connections to the city’s Clinical and Translational Science Awards (CTSA)s, community physician groups and healthcare organizations to better integrate clinical perspectives with deep discovery capabilities. The center also incorporates regulatory and implementation science into the hub. Projects funded by CBC-HITES will engage VC 1-2 years before equity financing is needed, and, depending on when they are screened out, unfunded projects receive a large body of research and a gap analysis that can be used for resubmission or alternative funding. VC are connected to promising AcIns and curated research, making their jobs easier. During their one to two years of training, EFs are networked to the universities, each other, and the broader ecosystem and then go to work in Chicago’s entrepreneurial ecosystem, pulling more academic assets out of the universities and thus maximizing the utility of their training. Intentionally recruiting diverse cohorts of EFs enables a strong, inclusive bioeconomy that can attract VC funding and more talent.