Sex differences in reward neurocircuitry underlying alcohol craving and consumption in trauma-exposed individuals

遭受创伤的个体对酒精的渴望和消费背后的奖赏神经回路的性别差异

• 批准号: 10785214
• 负责人: Cecilia A Hinojosa
• 金额: $ 13.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10785214
• 关键词: Alcohol consumption; Applications Grants; Award; Behavior; Bilateral; Biological; Black American; Brain; Clinic; Clinical; Collection; Complex; Consumption; Corpus striatum structure; Cross-Sectional Studies; Data; Data Analyses; Development; Diagnosis; Disease; Dopamine; Ecological momentary assessment; Educational workshop; Ensure; Epidemiology; Face; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Health; Healthcare; Human; Individual; Knowledge; Laboratories; Learning; Maintenance; Measures; Mediating; Mediation; Mentors; Minority Groups; Minority Women; Modeling; National Institute of Mental Health; Neurologic; Nucleus Accumbens; Participant; Pathway interactions; Pattern; Persons; Physician Executives; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Pre-Clinical Model; Predisposition; Prefrontal Cortex; Psychiatry; Publications; Research; Rewards; Role; Services; Severities; Sex Differences; Statistical Data Interpretation; Statistical Models; Students; Study Subject; Symptoms; Techniques; Testing; Training; Trauma; United States; United States National Institutes of Health; Universities; Woman; addiction; alcohol consequences; alcohol craving; alcohol effect; alcohol use disorder; dual diagnosis; empowerment; ethnic minority population; experience; human subject; meetings; men; mid-career faculty; multimodal neuroimaging; neural; neural circuit; neural correlate; neuroimaging; neuromechanism; neuropsychiatry; novel; post-trauma; preventive intervention; problem drinker; racial minority population; sex; skills; smartphone application; tenure track; trauma exposure; underrepresented minority student

PROJECT SUMMARY/ABSTRACT Candidate: My long-term goals are to acquire a tenure-track faculty position at a research-intensive university that serves students who reflect the diversity of the United States. My research will utilize multi-modal neuroimaging techniques to better understand the neural correlates and developmental relationship between posttraumatic stress disorder (PTSD) and alcohol use in women and racial/ethnic minority groups. I have a strong background in using structural and functional neuroimaging techniques to study the threat-related neurocircuitry related to the development and maintenance of PTSD. In this application, I propose to extend my training by first learning the basic neural mechanisms that promote alcohol use and how trauma exposure may contribute to neurological vulnerabilities in women, making this group more prone to using alcohol. Furthermore, I will build off the training I am already receiving through my Diversity Supplement award to learn how to use complex longitudinal statistical models to analyze ecological momentary assessment (EMA) data. Ultimately, this additional training will give me the skills to produce high-impact publications and successful R01 submissions. Training: In addition to Dr. Jennifer Stevens, I have a mentoring team filled with experts in academic research who will provide the necessary training and guidance to accomplish this proposal. Dr. Julie Kable is an Associate Professor of the Department of Psychiatry and Associate Director of the Emory Neurodevelopmental Exposure Clinic, Dr. Justine Welsh is an Associate Professor in the Department of Psychiatry and Director of the Emory Healthcare Addiction Services and Medical Director of the Addiction Alliance of Georgia, and Dr. Nicole Nugent is an Associate Professor at Brown University. Outside of the mentoring team, we have identified workshops, seminars, and meetings to provide further technical training, presentation experience, responsible conduct in research, and the necessary skills (negotiations, tenure, laboratory management) to transition to independence. Research: PTSD and alcohol use disorder (AUD) are highly co-occurring disorders (PTSD+AUD). Women are twice as likely than men to develop PTSD, and women face more detrimental health effects from alcohol compared to men. A large body of work has examined the neural mechanisms that underlie each disorder, separately. However, very few studies have examined the neural substrates of co-occurring PTSD+AUD, and none have examined sex differences. My preliminary data shows sex differences in the striatum, a region important in reward-related behavior. This proposal aims to define sex differences in reward-related neurocircuitry that contribute to alcohol use behaviors in trauma-exposed women. By using EMA and functional neuroimaging techniques, I anticipate expanding our understanding of sex differences in reward- related neurocircuitry that promote alcohol use in trauma-exposed populations. The successful completion of this proposed project has the potential to inform the development of preventative interventions to inhibit the development of AUD in trauma-exposed women.

项目总结/摘要 我的长期目标是在一所研究型大学获得终身教职 为反映美国多样性的学生提供服务。我的研究将利用多模态 神经影像学技术，以更好地了解神经相关性和发展之间的关系， 创伤后应激障碍（PTSD）和酒精使用的妇女和种族/少数民族群体。我有一种强烈 使用结构和功能神经成像技术研究威胁相关神经回路的背景 与PTSD的发展和维持有关。在这份申请中，我建议先延长我的培训时间， 学习促进酒精使用的基本神经机制以及创伤暴露如何有助于 女性的神经脆弱性，使这一群体更容易使用酒精。此外，我将建立 我已经通过我的多样性补充奖接受培训，学习如何使用复杂的 纵向统计模型分析生态瞬时评估（EMA）数据。最终这 额外的培训将使我掌握制作高影响力出版物和成功提交R 01的技能。 培训：除了Jennifer Stevens博士，我还有一个由学术研究专家组成的指导团队 他将提供必要的培训和指导来完成这项提议。朱莉·凯布尔博士是一名助理 精神病学系教授和埃默里神经发育暴露副主任 Justine Welsh博士是埃默里大学精神病学系副教授和主任。 医疗成瘾服务和格鲁吉亚成瘾联盟的医学主任，以及妮可·纽金特博士 是布朗大学的副教授在指导团队之外，我们还确定了研讨会， 研讨会和会议，以提供进一步的技术培训，演讲经验， 研究和必要的技能（谈判，任期，实验室管理）过渡到独立。 研究：PTSD和酒精使用障碍（AUD）是高度共同发生的疾病（PTSD+AUD）。妇女 患创伤后应激障碍的可能性是男性的两倍，女性面临更多酒精对健康的有害影响。 与男人相比。大量的工作已经研究了每种疾病背后的神经机制， 分开然而，很少有研究检查了共同发生的PTSD+AUD的神经底物， 没有人研究过性别差异。我的初步数据显示，在纹状体，一个区域的性别差异 在奖励相关的行为中很重要。这项建议旨在界定与奖励有关的性别差异 神经回路，有助于创伤暴露妇女的酒精使用行为。通过使用EMA和 功能性神经成像技术，我期望扩大我们对奖励的性别差异的理解- 相关的神经回路，促进创伤暴露人群中的酒精使用。圆满完成 这一拟议项目有可能为制定预防性干预措施提供信息， 在创伤暴露女性中发生AUD。