Modeling Physiology and Behavior of Veterans to Avert Opioid Related Mortality Through Timely Intervention

对退伍军人的生理和行为进行建模，通过及时干预避免阿片类药物相关的死亡

• 批准号: 10773711
• 负责人: SARAH E FORSTER
• 金额: $ 5.5万
• 依托单位: BEHAIVIOR, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-08 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10773711
• 关键词: Address; Affect; Age; Annual Reports; Behavior; Caring; Centers for Disease Control and Prevention (U.S.); Clinical Research; Communities; Data; Development; Education; Epidemic; Face; Gender Identity; General Population; Health system; High Prevalence; Incidence; Income; Individual; Injury; Innovation Corps; Insurance Carriers; Intervention; Learning; Life; Literature; Marketing; Mental Health; Military Personnel; Modeling; Opiate Addiction; Opioid; Pain; Persons; Phase; Physiology; Population; Post-Traumatic Stress Disorders; Race; Recovery; Reporting; Resistance; Risk; Stress; Substance Use Disorder; Suicide; Suicide prevention; System; Technology; Time; United States; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Veterans; addiction; care providers; career; chronic pain; help-seeking behavior; innovation; mental state; military veteran; mortality; novel; opioid epidemic; opioid misuse; opioid overdose; overdose death; remote intervention; remote monitoring; return to use; seal; severe mental illness; social stigma; software as a service; stressor; substance use; suicidal; suicide rate; tool

Project Summary/Abstract Opioid addiction affects people of all races, ages, gender identities, education, and income levels across the United States. The epidemic has been intensifying in recent years, with return to use (RTU) rates reaching close to 91% (Kadam et al., 2017) and provisional data from 2020 indicating the highest number of overdose deaths ever recorded in a year, over 88,000 (Centers for Disease Control and Prevention, 2020). Further, only 10-20% of people struggling with addiction receive care for their OUD (Substance Abuse and Mental Health Services Administration, 2020). An increasing body of literature exposes a population extremely vulnerable to opioid addiction and overdose: United States veterans. Veterans face unique challenges that predispose them to greater risk for misusing opioids such as a higher prevalence of and more severe pain than the general population (Nahin, 2017), and the stresses and risks of deployment that often result in PTSD upon return to civilian life (Seal et al., 2012). Indeed, this group, though not monolithic, may be generally resistant to support; half of the military personnel reported that they believe seeking help for mental health issues would harm their military career. Suicide rates continue to rise, faster in the veteran population than in the non-veteran population, despite the decrease in the populational proportion of veterans. In 2018, almost one in seven suicides in the U.S. was a veteran (“2020 National Veteran Suicide Prevention Annual Report”, 2020). Mental health issues affect substance use disorders as well. Nationwide, the rate of overdose deaths in veterans increased by 65% from 2010 to 2016 (Lewei et al., 2019). The stressors of deployment during wartime that are often difficult to shake off upon return to civilian life, incidences of injuries resulting in severe and often chronic pain, and the nuances of military culture, combined with stigmas associated with OUD, perpetuate a detrimental cycle of addiction for veterans. To address this, Behaivior is developing a novel solution that addresses the mental health of veterans nationally via a first-of-its-kind remote monitoring and intervention software-as-a-service offering. Our system builds upon our technology stack and learnings from clinical studies on individuals with OUD. Given that substance use in the veteran population often precedes a deleterious cycle commonly resulting in serious and persistent mental illness (SPMI) and sometimes even suicide, advanced and real-time remote monitoring of the state of mental health is an important indicator. This tool provides timely interventions that address OUD and further averts the progression of SPMI as well as suicidal tendencies. Behaivior knows a commercial opportunity exists because care providers, insurers, communities, and health systems are desperately seeking innovative ways to address the opioid epidemic and the overwhelming fatal opioid-related overdose deaths. I-Corps learnings will expedite the deployment of mitigation solutions.

项目总结/摘要 阿片类药物成瘾影响着世界各地所有种族、年龄、性别认同、教育和收入水平的人。 美国的近年来，这一流行病一直在加剧，恢复使用率（RTU）达到100%。 接近91%（Kadam等人，2017年）和2020年的临时数据表明， 一年中有记录的死亡人数超过88，000人（疾病控制和预防中心，2020年）。此外，只有 10-20%的人与成瘾作斗争接受照顾他们的OUD（物质滥用和心理健康） 服务管理，2020）。越来越多的文献揭露了一个人口极易受到 阿片类药物成瘾和过量：美国退伍军人 退伍军人面临着独特的挑战，使他们更容易滥用阿片类药物， 疼痛的患病率和严重程度高于一般人群（Nahin，2017），压力和 在返回平民生活时经常导致PTSD的部署风险（Seal等人，2012年）。事实上，这一群体， 虽然不是铁板一块，但可能普遍抵制支持;一半的军事人员报告说，他们 认为寻求心理健康问题的帮助会损害他们的军事生涯。自杀率持续上升， 在退伍军人人口比非退伍军人人口更快，尽管人口减少， 退伍军人的比例。2018年，美国近七分之一的自杀者是退伍军人（“2020年全国 《预防自杀年度报告》，2020年。精神健康问题影响物质使用障碍， 好.在全国范围内，退伍军人的过量死亡率从2010年到2016年增加了65%（Lewei等人， 2019年）。战时部署的压力因素，在返回平民后往往难以摆脱 生活，受伤的发生率导致严重的，往往是慢性疼痛，和军事文化的细微差别， 再加上与OUD相关的耻辱，使退伍军人的成瘾循环永久化。 为了解决这个问题，Behaivior正在开发一种新的解决方案，解决退伍军人的心理健康问题。 通过首创的远程监控和干预软件即服务产品在全国范围内实现。我们的系统 建立在我们的技术堆栈和从OUD患者的临床研究中学习的基础上。鉴于 退伍军人群体中的物质使用通常在一个有害的循环之前， 持续性精神疾病（SPMI），有时甚至自杀，先进的和实时的远程监测， 心理健康状况是一个重要指标。该工具提供及时的干预措施来解决OUD问题， 进一步避免了SPMI的进展以及自杀倾向。Behaivior知道一个广告 机会之所以存在，是因为医疗服务提供者、保险公司、社区和卫生系统都在拼命寻求 以创新方式解决类阿片流行病和与类阿片有关的大量致命性过量死亡问题。 I-Corps的学习将加快缓解解决方案的部署。