Modeling Physiology and Behavior of Veterans to Avert Opioid Related Mortality Through Timely Intervention

项目摘要/摘要 阿片成瘾影响着所有种族、年龄、性别认同、教育程度和收入水平的人 美国。近年来，疫情一直在加剧，恢复使用(RTU)率达到 接近91%(Kadam等人，2017年)和2020年的临时数据，表明过量服药的人数最多 一年内有记录的死亡人数超过8.8万人(疾病控制和预防中心，2020年)。此外，只有 10%-20%的瘾君子接受治疗(药物滥用和心理健康 服务业管理局，2020)。越来越多的文学作品暴露了极易受到 阿片成瘾和过量：美国退伍军人。 退伍军人面临着独特的挑战，这使他们更有可能滥用阿片类药物，如 比普通人群更高的患病率和更严重的疼痛(Nahin，2017)，以及压力和 在重返平民生活后往往导致创伤后应激障碍的部署风险(Seal等人，2012年)。的确，这群人， 虽然不是铁板一块，但可能普遍抵制支持；一半的军事人员报告说，他们 认为寻求心理健康问题的帮助会损害他们的军旅生涯。自杀率持续上升， 退伍军人人口比非退伍军人人口更快，尽管人口减少 退伍军人比例。2018年，美国几乎每七个自杀者中就有一个是退伍军人 《退伍军人自杀预防年度报告》，2020年)。精神健康问题会影响物质使用障碍，因为 井。在全国范围内，从2010年到2016年，退伍军人服药过量死亡率增加了65%(Lewei等人， 2019年)。战时部署的压力，回到平民后往往很难摆脱 生活，导致严重和经常是慢性疼痛的伤害发生率，以及军事文化的细微差别， 再加上与OUD相关的耻辱，使退伍军人的毒瘾恶性循环永久化。 为了解决这个问题，Behaivior正在开发一种新的解决方案，以解决退伍军人的心理健康问题 在全国范围内，通过首创的远程监测和干预软件即服务产品。我们的系统 建立在我们的技术堆栈和对OUD患者的临床研究的基础上。考虑到 在退伍军人中使用药物往往先于一个有害的循环，通常导致严重和 持续性精神疾病(SPMI)，有时甚至自杀，高级和实时远程监控 心理健康状况是一个重要的指标。此工具提供及时的干预，以解决OUD和 进一步避免SPMI的进展以及自杀倾向。Behaivior知道一个广告 机会之所以存在，是因为护理提供者、保险公司、社区和卫生系统正在拼命寻找 以创新方式应对阿片类药物流行和与阿片类药物过量有关的压倒性致命死亡。 I-Corps的学习将加快缓解解决方案的部署。

Project Summary/Abstract Opioid addiction affects people of all races, ages, gender identities, education, and income levels across the United States. The epidemic has been intensifying in recent years, with return to use (RTU) rates reaching close to 91% (Kadam et al., 2017) and provisional data from 2020 indicating the highest number of overdose deaths ever recorded in a year, over 88,000 (Centers for Disease Control and Prevention, 2020). Further, only 10-20% of people struggling with addiction receive care for their OUD (Substance Abuse and Mental Health Services Administration, 2020). An increasing body of literature exposes a population extremely vulnerable to opioid addiction and overdose: United States veterans. Veterans face unique challenges that predispose them to greater risk for misusing opioids such as a higher prevalence of and more severe pain than the general population (Nahin, 2017), and the stresses and risks of deployment that often result in PTSD upon return to civilian life (Seal et al., 2012). Indeed, this group, though not monolithic, may be generally resistant to support; half of the military personnel reported that they believe seeking help for mental health issues would harm their military career. Suicide rates continue to rise, faster in the veteran population than in the non-veteran population, despite the decrease in the populational proportion of veterans. In 2018, almost one in seven suicides in the U.S. was a veteran (“2020 National Veteran Suicide Prevention Annual Report”, 2020). Mental health issues affect substance use disorders as well. Nationwide, the rate of overdose deaths in veterans increased by 65% from 2010 to 2016 (Lewei et al., 2019). The stressors of deployment during wartime that are often difficult to shake off upon return to civilian life, incidences of injuries resulting in severe and often chronic pain, and the nuances of military culture, combined with stigmas associated with OUD, perpetuate a detrimental cycle of addiction for veterans. To address this, Behaivior is developing a novel solution that addresses the mental health of veterans nationally via a first-of-its-kind remote monitoring and intervention software-as-a-service offering. Our system builds upon our technology stack and learnings from clinical studies on individuals with OUD. Given that substance use in the veteran population often precedes a deleterious cycle commonly resulting in serious and persistent mental illness (SPMI) and sometimes even suicide, advanced and real-time remote monitoring of the state of mental health is an important indicator. This tool provides timely interventions that address OUD and further averts the progression of SPMI as well as suicidal tendencies. Behaivior knows a commercial opportunity exists because care providers, insurers, communities, and health systems are desperately seeking innovative ways to address the opioid epidemic and the overwhelming fatal opioid-related overdose deaths. I-Corps learnings will expedite the deployment of mitigation solutions.